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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00007403naa a2200541 4500
001oai:DiVA.org:oru-67021
003SwePub
008180604s2018 | |||||||||||000 ||eng|
009oai:prod.swepub.kib.ki.se:138705454
009oai:lup.lub.lu.se:a6d9bd1a-d0d8-4d4e-976f-64bb8f9b1292
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-670212 URI
0247 a https://doi.org/10.1093/carcin/bgy0592 DOI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1387054542 URI
0247 a https://lup.lub.lu.se/record/a6d9bd1a-d0d8-4d4e-976f-64bb8f9b12922 URI
040 a (SwePub)orud (SwePub)kid (SwePub)lu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Alhamdow, Aymanu Karolinska Institute,Karolinska Institutet4 aut0 (Swepub:lu)med-aa10
2451 0a DNA-methylation of the cancer-related genes F2RL3 and AHRR is associated with occupational exposure to polycyclic aromatic hydrocarbons
264 c 2018-05-02
264 1b Oxford University Press,c 2018
338 a print2 rdacarrier
500 a Funding Agency:Medical Training and Research Agreement (ALF grants; Region Örebro län)  OLL-550721
520 a Some polycyclic aromatic hydrocarbons (PAH) are known carcinogens and workplace PAH exposure may increase the risk of cancer. Monitoring early cancer-related changes can indicate whether the exposure is carcinogenic. Here, we enrolled 151 chimney sweeps, 152 controls, and 19 creosote-exposed male workers from Sweden. We measured urinary PAH metabolites using LC/MS/MS, the cancer-related markers telomere length (TL) and mitochondrial DNA copy number (mtDNAcn) using qPCR, and DNA methylation of lung cancer-related genes F2RL3 and AHRR using pyrosequencing. The median 1-hydroxypyrene (PAH metabolite) concentrations were highest in creosote-exposed workers (8.0 μg/g creatinine) followed by chimney sweeps (0.34 μg/g creatinine) and controls (0.05 μg/g creatinine). TL and mtDNAcn did not differ between study groups. Chimney sweeps and creosote-exposed workers had significantly lower methylation of AHRR CpG site cg05575921 (88.1% and 84.9%, respectively) than controls (90%). Creosote-exposed workers (73.3%), but not chimney sweeps (76.6%) had lower methylation of F2RL3 cg03636183 than controls (76.7%). Linear regression analyses showed that chimney sweeps had lower AHRR cg05575921 methylation (B=-2.04; P<0.057, adjusted for smoking and age) and lower average AHRR methylation (B=-2.05; P<0.035), and non-smoking chimney sweeps had lower average F2RL3 methylation (B=-0.81; P<0.042, adjusted for age) compared with controls. These cancer-related markers were not associated with urinary concentrations of PAH metabolites. In conclusion, although we found no associations with PAH metabolites in urine (short-term exposure), our results suggest dose-response relationship between PAH exposure and DNA hypomethylation of lung cancer-related loci. These findings indicate that further protective measures should be taken to reduce PAH exposure.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskapx Arbetsmedicin och miljömedicin0 (SwePub)303032 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Health Sciencesx Occupational Health and Environmental Health0 (SwePub)303032 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
7001 a Lindh, Christianu Lund University,Lunds universitet,Avdelningen för arbets- och miljömedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Tillämpad masspektrometri inom miljömedicin,Forskargrupper vid Lunds universitet,Division of Occupational and Environmental Medicine, Lund University,Department of Laboratory Medicine,Faculty of Medicine,Applied Mass Spectrometry in Environmental Medicine,Lund University Research Groups4 aut0 (Swepub:lu)ymed-cli
7001 a Hagberg, Jessika,d 1974-u Örebro University,Örebro universitet,Institutionen för naturvetenskap och teknik,Department of Occupational and Environmental Medicine, Faculty of Medicine and Health, Örebro University, Örebro, Sweden,MTM Research Centre4 aut0 (Swepub:oru)jahg
7001 a Graff, Pål,d 1973-u Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Department of Occupational and Environmental Medicine, Faculty of Medicine and Health, Örebro University, Örebro, Sweden; National Institute of Occupational Health, Oslo, Norway4 aut0 (Swepub:oru)pgf
7001 a Westberg, Håkan,d 1949-u Örebro University,Örebro universitet,Institutionen för naturvetenskap och teknik,Department of Occupational and Environmental Medicine, Faculty of Medicine and Health, Örebro University, Örebro, Sweden,MTM Research Centre4 aut0 (Swepub:oru)hwg
7001 a Krais, Annette Mu Lund University,Lunds universitet,Avdelningen för arbets- och miljömedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Tillämpad masspektrometri inom miljömedicin,Forskargrupper vid Lunds universitet,Division of Occupational and Environmental Medicine, Lund University,Department of Laboratory Medicine,Faculty of Medicine,Applied Mass Spectrometry in Environmental Medicine,Lund University Research Groups4 aut0 (Swepub:lu)med-ak5
7001 a Albin, Mariau Lund University,Lunds universitet,Stockholm County Council,Karolinska Institute,Karolinska Institutet,Avdelningen för arbets- och miljömedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Arbetsorganisation och hälsa,Forskargrupper vid Lunds universitet,Division of Occupational and Environmental Medicine, Lund University,Department of Laboratory Medicine,Faculty of Medicine,Environmental health and occupational health,Lund University Research Groups4 aut0 (Swepub:lu)ymed-mal
7001 a Gustavsson, Peru Karolinska Institutet4 aut
7001 a Tinnerberg, Håkanu Lund University,Lunds universitet,Avdelningen för arbets- och miljömedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Occupational and Environmental Medicine, Lund University,Department of Laboratory Medicine,Faculty of Medicine4 aut0 (Swepub:lu)ymed-hti
7001 a Broberg, Karinu Karolinska Institute,Lund University,Lunds universitet,Karolinska Institutet,Avdelningen för arbets- och miljömedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Occupational and Environmental Medicine, Lund University,Department of Laboratory Medicine,Faculty of Medicine4 aut0 (Swepub:lu)kgen-kbr
7102 a Karolinska Instituteb Karolinska Institutet4 org
7730 t Carcinogenesisd : Oxford University Pressg 39:7, s. 869-878q 39:7<869-878x 0143-3334x 1460-2180
8564 u https://doi.org/10.1093/carcin/bgy059y Fulltext
8564 u https://academic.oup.com/carcin/article-pdf/39/7/869/25121411/bgy059.pdf
8564 u http://dx.doi.org/10.1093/carcin/bgy059x freey FULLTEXT
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-67021
8564 8u https://doi.org/10.1093/carcin/bgy059
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:138705454
8564 8u https://lup.lub.lu.se/record/a6d9bd1a-d0d8-4d4e-976f-64bb8f9b1292

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