Sökning: WFRF:(Grünwald Jan) > Haploidentical vs s...
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000 | 12975naa a2201273 4500 | |
001 | oai:DiVA.org:uu-469231 | |
003 | SwePub | |
008 | 220308s2022 | |||||||||||000 ||eng| | |
009 | oai:prod.swepub.kib.ki.se:148866865 | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4692312 URI |
024 | 7 | a https://doi.org/10.1182/bloodadvances.20210049162 DOI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1488668652 URI |
040 | a (SwePub)uud (SwePub)ki | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Wieduwilt, Matthew J.u Univ Oklahoma, Stephenson Canc Ctr, Oklahoma City, OK 73106 USA.4 aut |
245 | 1 0 | a Haploidentical vs sibling, unrelated, or cord blood hematopoietic cell transplantation for acute lymphoblastic leukemia |
264 | c 2022-01-11 | |
264 | 1 | b American Society of Hematology,c 2022 |
338 | a electronic2 rdacarrier | |
520 | a The role of haploidentical hematopoietic cell transplantation (HCT) using posttransplant cyclophosphamide (PTCy) for acute lymphoblastic leukemia (ALL) is being defined. We performed a retrospective, multivariable analysis comparing outcomes of HCT approaches by donor for adults with ALL in remission. The primary objective was to compare overall survival (OS) among haploidentical HCTs using PTCy and HLA-matched sibling donor (MSD), 8/8 HLAmatched unrelated donor (MUD), 7 /8 HLA-MUD, or umbilical cord blood (UCB) HCT. Comparing haploidentical HCT to MSD HCT, we found that OS, leukemia-free survival (LFS), nonrelapse mortality (NRM), relapse, and acute graft-versus-host disease (aGVHD) were not different but chronic GVHD (cGVHD) was higher in MSD HCT. Compared with MUD HCT, OS, LFS, and relapse were not different, but MUD HCT had increased NRM (hazard ratio [HR], 1.42; P = .02), grade 3 to 4 aGVHD (HR, 1.59; P = .005), and cGVHD. Compared with 7/8 UD HCT, LFS and relapse were not different, but 7/8 UD HCT had worse OS (HR, 1.38; P = .01) and increased NRM (HR, 2.13; P <_ .001), grade 3 to 4 aGVHD (HR, 1.86; P = .003), and cGVHD (HR, 1.72; P <_ .001). Compared with UCB HCT, late OS, late LFS, relapse, and cGVHD were not different but UCB HCT had worse early OS (<_18 months; HR, 1.93; P < .001), worse early LFS (HR, 1.40; P = .007) and increased incidences of NRM (HR, 2.08; P < .001) and grade 3 to 4 aGVHD (HR, 1.97; P < .001). Haploidentical HCT using PTCy showed no difference in survival but less GVHD compared with traditional MSD and MUD HCT and is the preferred alternative donor HCT option for adults with ALL in complete remission. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Hematologi0 (SwePub)302022 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Hematology0 (SwePub)302022 hsv//eng |
700 | 1 | a Metheny, Lelandu Univ Hosp Seidman Canc Ctr, Cleveland, OH USA.4 aut |
700 | 1 | a Zhang, Mei-Jieu Med Coll Wisconsin, Dept Med, Ctr Int Blood & Marrow Transplant Res, Milwaukee, WI 53226 USA.;Med Coll Wisconsin, Inst Hlth & Equ, Div Biostat, Milwaukee, WI 53226 USA.4 aut |
700 | 1 | a Wang, Hai-Linu Med Coll Wisconsin, Dept Med, Ctr Int Blood & Marrow Transplant Res, Milwaukee, WI 53226 USA.4 aut |
700 | 1 | a Estrada-Merly, Noelu Med Coll Wisconsin, Dept Med, Ctr Int Blood & Marrow Transplant Res, Milwaukee, WI 53226 USA.4 aut |
700 | 1 | a Marks, David, Iu Univ Hosp Bristol Natl Hlth Serv Trust, Adult Bone Marrow Transplant, Bristol, Avon, England.4 aut |
700 | 1 | a Al-Homsi, A. Sameru New York Univ Langone Hlth, New York, NY USA.4 aut |
700 | 1 | a Muffly, Loriu Stanford Univ, Div Blood & Marrow Transplantat, Stanford, CA 94305 USA.4 aut |
700 | 1 | a Chao, Nelsonu Duke Univ, Med Ctr, Dept Med, Div Cell Therapy & Hematol, Durham, NC 27710 USA.4 aut |
700 | 1 | a Rizzieri, Davidu Duke Univ, Div Hematol Malignancies & Cellular Therapy, Durham, NC USA.4 aut |
700 | 1 | a Gale, Robert Peteru Imperial Coll London, Haematol Res Ctr, Dept Immunol & Inflammat, London, England.4 aut |
700 | 1 | a Gadalla, Shahinaz M.u NCI, Div Canc Epidemiol & Genet, Clin Genet Branch, NIH, Rockville, MD USA.4 aut |
700 | 1 | a Cairo, Mitchellu New York Med Coll, Dept Pediat, Div Pediat Hematol Oncol & Stem Cell Transplantat, Valhalla, NY 10595 USA.4 aut |
700 | 1 | a Mussetti, Albertou Inst Catala Oncol Hosp, Hematol Dept, Barcelona, Spain.;Inst Catala Oncol, Inst Invest Biomed Bellvitge, Lhospitalet De Llobregat, El Prat De Llob, Spain.4 aut |
700 | 1 | a Gore, Stevenu Yale New Haven Med Ctr, 20 York St, New Haven, CT 06504 USA.4 aut |
700 | 1 | a Bhatt, Vijaya Raju Univ Nebraska Med Ctr, Fred & Pamela Buffett Canc Ctr, Omaha, NE USA.4 aut |
700 | 1 | a Patel, Sagar S.u Univ Utah, Huntsman Canc Inst, Blood & Marrow Transplant Program, Salt Lake City, UT USA.4 aut |
700 | 1 | a Michelis, Fotios, Vu Princess Margaret Canc Ctr, Allogene Blood & Marrow Transplant Program, Toronto, ON, Canada.4 aut |
700 | 1 | a Inamoto, Yoshihirou Natl Canc Ctr, Div Hematopoiet Stem Cell Transplantat, Tokyo, Japan.4 aut |
700 | 1 | a Badawy, Sherif M.u Ann & Robert H Lurie Childrens Hosp Chicago, Div Hematol Oncol & Stem Cell Transplant, Chicago, IL 60611 USA.;Northwestern Univ, Dept Pediat, Feinberg Sch Med, Chicago, IL 60611 USA.4 aut |
700 | 1 | a Copelan, Edwardu Atrium Hlth, Dept Hematol Oncol & Blood Disorders, Levine Canc Inst, Charlotte, NC USA.4 aut |
700 | 1 | a Palmisiano, Neilu Thomas Jefferson Univ, Sidney Kimmel Canc Ctr, Philadelphia, PA 19107 USA.4 aut |
700 | 1 | a Kharfan-Dabaja, Mohamed A.u Mayo Clin, Blood & Marrow Transplantat Program, Div Hematol Oncol, Jacksonville, FL 32224 USA.4 aut |
700 | 1 | a Lazarus, Hillard M.u Case Western Reserve Univ, Univ Hosp Cleveland, Med Ctr, Cleveland, OH 44106 USA.4 aut |
700 | 1 | a Ganguly, Siddharthau Univ Kansas Hlth Syst, Div Hematol Malignancies & Cellular Therapeut, Kansas City, KS USA.4 aut |
700 | 1 | a Bredeson, Christopheru Ottawa Hosp, Transplant & Cellular Therapy Program, Ottawa, ON, Canada.4 aut |
700 | 1 | a Diaz Perez, Miguel Angelu Hosp Infantil Univ Nino Jesus, Dept Hematol Oncol, Madrid, Spain.4 aut |
700 | 1 | a Cassaday, Ryanu Univ Washington, Fred Hutchinson Canc Res Ctr, Seattle, WA 98195 USA.4 aut |
700 | 1 | a Savani, Bipin N.u Vanderbilt Univ, Med Ctr, Dept Med, Div Hematol Oncol, Nashville, TN USA.4 aut |
700 | 1 | a Ballen, Karenu Univ Virginia Hlth Syst, Div Hematol Oncol, Charlottesville, VA USA.4 aut |
700 | 1 | a Martino, Rodrigou Hosp Santa Creu & Sant Pau, Div Clin Hematol, Barcelona, Spain.4 aut |
700 | 1 | a Wirk, Baldeepu Penn State Canc Inst, Bone Marrow Transplant Program, Hershey, PA USA.4 aut |
700 | 1 | a Bacher, Ulrikeu Univ Bern, Bern Univ Hosp, Dept Hematol, Inselspital, Bern, Switzerland.4 aut |
700 | 1 | a Aljurf, Mahmoudu King Faisal Specialist Hosp Ctr & Res, Dept Oncol, Riyadh, Saudi Arabia.4 aut |
700 | 1 | a Bashey, Asadu Northside Hosp, Blood & Marrow Transplant Program, Atlanta, GA USA.4 aut |
700 | 1 | a Murthy, Hemant S.u Mayo Clin, Blood & Marrow Transplantat Program, Div Hematol Oncol, Jacksonville, FL 32224 USA.4 aut |
700 | 1 | a Yared, Jean A.u Univ Maryland, Dept Med, Greenebaum Comprehens Canc Ctr, Blood & Marrow Transplantat Program,Div Hematol O, Baltimore, MD 21201 USA.4 aut |
700 | 1 | a Aldoss, Ibrahimu City Hope Med Ctr, Duarte, CA USA.4 aut |
700 | 1 | a Farhadfar, Noshau Univ Florida, Div Hematol Oncol, Coll Med, Gainesville, FL USA.4 aut |
700 | 1 | a Liu, Hongtaou Univ Chicago Med, Sect Hematol Oncol, Chicago, IL USA.4 aut |
700 | 1 | a Abdel-Azim, Hishamu Univ Southern Calif, Childrens Hosp Los Angeles, Div Hematol Oncol & Blood & Marrow Transplantat, Keck Sch Med, Los Angeles, CA 90007 USA.4 aut |
700 | 1 | a Waller, Edmund K.u Emory Univ, Winship Canc Inst, Dept Hematol & Med Oncol, Atlanta, GA 30322 USA.4 aut |
700 | 1 | a Solh, Melhemu Northside Hosp, Blood & Marrow Transplant Grp Georgia, Atlanta, GA USA.4 aut |
700 | 1 | a Seftel, Matthew D.u Univ British Columbia, Dept Med, Vancouver, BC, Canada.4 aut |
700 | 1 | a van der Poel, Marjoleinu Maastricht Univ, Med Ctr, Maastricht, Netherlands.4 aut |
700 | 1 | a Grunwald, Michael R.u Atrium Hlth, Dept Hematol Oncol & Blood Disorders, Levine Canc Inst, Charlotte, NC USA.4 aut |
700 | 1 | a Liesveld, Jane L.u Univ Rochester, Med Ctr, Dept Med, Rochester, NY 14642 USA.4 aut |
700 | 1 | a Kamble, Rammurti T.u Baylor Coll Med, Ctr Cell & Gene Therapy, Div Hematol & Oncol, Houston, TX 77030 USA.4 aut |
700 | 1 | a McGuirk, Josephu Univ Kansas Hlth Syst, Div Hematol Malignancies & Cellular Therapeut, Kansas City, KS USA.4 aut |
700 | 1 | a Munker, Reinholdu Univ Kentucky, Markey Canc Ctr, Lexington, KY USA.4 aut |
700 | 1 | a Cahn, Jean-Yvesu Univ Grenoble Alpes, Ctr Hosp Univ Grenoble Alpes, Dept Hematol, Grenoble, France.4 aut |
700 | 1 | a Lee, Jong Wooku Catholic Univ Korea, Div Hematol, Seoul St Marys Hosp, Seoul, South Korea.4 aut |
700 | 1 | a Freytes, Cesar O.u Univ Texas Hlth Sci Ctr San Antonio, San Antonio, TX 78229 USA.4 aut |
700 | 1 | a Krem, Maxwell M.u Univ Kentucky, Markey Canc Ctr, Lexington, KY USA.4 aut |
700 | 1 | a Winestone, Lena E.u Univ Calif San Francisco, Benioff Childrens Hosp, Div Allergy Immunol & Blood & Marrow Transplant, San Francisco, CA 94143 USA.4 aut |
700 | 1 | a Gergis, Usamau Thomas Jefferson Univ, Div Hematol Malignancies, Dept Med Oncol, Philadelphia, PA 19107 USA.4 aut |
700 | 1 | a Nathan, Sunitau Rush Univ, Med Ctr, Sect Bone Marrow Transplant & Cell Therapy, Chicago, IL 60612 USA.4 aut |
700 | 1 | a Olsson, Richard F.u Uppsala universitet,Centrum för klinisk forskning i Sörmland (CKFD),Karolinska Inst, Dept Lab Med, Stockholm, Sweden.4 aut0 (Swepub:uu)riols677 |
700 | 1 | a Verdonck, Leo F.u Isala Clin, Dept Hematol Oncol, Zwolle, Netherlands.4 aut |
700 | 1 | a Sharma, Akshayu St Jude Childrens Res Hosp, Dept Bone Marrow Transplantat & Cellular Therapy, 332 N Lauderdale St, Memphis, TN 38105 USA.4 aut |
700 | 1 | a Ringden, Olleu Karolinska Institutet4 aut |
700 | 1 | a Friend, Brian D.u Baylor Coll Med, Ctr Cell & Gene Therapy, Houston, TX 77030 USA.4 aut |
700 | 1 | a Cerny, Janu Univ Massachusetts, Med Ctr, Dept Med, Div Hematol Oncol, Worcester, MA USA.4 aut |
700 | 1 | a Choe, Hannahu Ohio State Univ, James Comprehens Canc Ctr, Wexner Med Ctr, Columbus, OH 43210 USA.4 aut |
700 | 1 | a Chhabra, Saurabhu Med Coll Wisconsin, Dept Med, Ctr Int Blood & Marrow Transplant Res, Milwaukee, WI 53226 USA.;Med Coll Wisconsin, Dept Med, Div Hematol Oncol, Milwaukee, WI 53226 USA.4 aut |
700 | 1 | a Nishihori, Taigau H Lee Moffitt Canc Ctr & Res Inst, Dept Blood & Marrow Transplant & Cellular Immunot, Tampa, FL USA.4 aut |
700 | 1 | a Seo, Sachikou Dokkyo Med Univ, Dept Hematol & Oncol, Mibu, Tochigi, Japan.4 aut |
700 | 1 | a George, Bijuu Christian Med Coll & Hosp, Vellore, Tamil Nadu, India.4 aut |
700 | 1 | a Baxter-Lowe, Lee Annu Childrens Hosp Los Angeles, Los Angeles, CA 90027 USA.4 aut |
700 | 1 | a Hildebrandt, Gerhard C.u Univ Kentucky, Markey Canc Ctr, Lexington, KY USA.4 aut |
700 | 1 | a de Lima, Marcosu Univ Hosp Case Med Ctr, Seidman Canc Ctr, Dept Med, Cleveland, OH USA.4 aut |
700 | 1 | a Litzow, Marku Mayo Clin Rochester, Div Hematol, Rochester, MN USA.;Mayo Clin Rochester, Transplant Ctr, Rochester, MN USA.4 aut |
700 | 1 | a Kebriaei, Partowu Univ Texas MD Anderson Canc Ctr, Dept Stem Cell Transplantat, Div Canc Med, Houston, TX 77030 USA.4 aut |
700 | 1 | a Hourigan, Christopher S.u NHLBI, Lab Myeloid Malignancies, NIH, Bldg 10, Bethesda, MD 20892 USA.4 aut |
700 | 1 | a Abid, Muhammad Bilalu Med Coll Wisconsin, Dept Med, Div Hematol Oncol, Milwaukee, WI 53226 USA.;Med Coll Wisconsin, Dept Med, Div Infect Dis, Milwaukee, WI 53226 USA.4 aut |
700 | 1 | a Weisdorf, Daniel J.u Univ Minnesota, Dept Med, Div Hematol Oncol & Transplantat, Box 736 UMHC, Minneapolis, MN 55455 USA.4 aut |
700 | 1 | a Saber, Waelu Med Coll Wisconsin, Dept Med, Ctr Int Blood & Marrow Transplant Res, Milwaukee, WI 53226 USA.4 aut |
710 | 2 | a Univ Oklahoma, Stephenson Canc Ctr, Oklahoma City, OK 73106 USA.b Univ Hosp Seidman Canc Ctr, Cleveland, OH USA.4 org |
773 | 0 | t Blood Advancesd : American Society of Hematologyg 6:1, s. 339-357q 6:1<339-357x 2473-9529x 2473-9537 |
856 | 4 | u https://doi.org/10.1182/bloodadvances.2021004916y Fulltext |
856 | 4 | u https://uu.diva-portal.org/smash/get/diva2:1642828/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print |
856 | 4 | u https://ashpublications.org/bloodadvances/article-pdf/doi/10.1182/bloodadvances.2021004916/1823558/bloodadvances.2021004916.pdf |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-469231 |
856 | 4 8 | u https://doi.org/10.1182/bloodadvances.2021004916 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:148866865 |
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