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SARS-CoV-2 infection causes immunodeficiency in recovered patients by downregulating CD19 expression in B cells via enhancing B-cell metabolism
- Jing, YK (author)
- Luo, L (author)
- Chen, Y (author)
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- Zhou, P (author)
- Xu, ZP (author)
- Herrada, AA (author)
- Park, CS (author)
- Kubo, M (author)
- Mei, H (author)
- Hu, Y (author)
- Lee, PPW (author)
- Zheng, B (author)
- Sui, ZW (author)
- Xiao, W (author)
- Gong, Q (author)
- Lu, ZX (author)
- Liu, CH (author)
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- (creator_code:org_t)
- 2021-09-22
- 2021
- English.
- In: Signal transduction and targeted therapy. - : Springer Science and Business Media LLC. - 2059-3635. ; 6:1, s. 345-
- Journal article (peer-reviewed)
Abstract
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- The SARS-CoV-2 infection causes severe immune disruption. However, it is unclear if disrupted immune regulation still exists and pertains in recovered COVID-19 patients. In our study, we have characterized the immune phenotype of B cells from 15 recovered COVID-19 patients, and found that healthy controls and recovered patients had similar B-cell populations before and after BCR stimulation, but the frequencies of PBC in patients were significantly increased when compared to healthy controls before stimulation. However, the percentage of unswitched memory B cells was decreased in recovered patients but not changed in healthy controls upon BCR stimulation. Interestingly, we found that CD19 expression was significantly reduced in almost all the B-cell subsets in recovered patients. Moreover, the BCR signaling and early B-cell response were disrupted upon BCR stimulation. Mechanistically, we found that the reduced CD19 expression was caused by the dysregulation of cell metabolism. In conclusion, we found that SARS-CoV-2 infection causes immunodeficiency in recovered patients by downregulating CD19 expression in B cells via enhancing B-cell metabolism, which may provide a new intervention target to cure COVID-19.
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- Jing, YK
- Luo, L
- Chen, Y
- Westerberg, LS
- Zhou, P
- Xu, ZP
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- Herrada, AA
- Park, CS
- Kubo, M
- Mei, H
- Hu, Y
- Lee, PPW
- Zheng, B
- Sui, ZW
- Xiao, W
- Gong, Q
- Lu, ZX
- Liu, CH
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- Karolinska Institutet
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