Prospects for systems biology and modeling of the gut microbiome

Karlsson, Fredrik, 1984 (författare): Chalmers tekniska högskola,Chalmers University of Technology

Nookaew, Intawat, 1977 (författare): Chalmers tekniska högskola,Chalmers University of Technology

Petranovic Nielsen, Dina, 1975 (författare): Chalmers tekniska högskola,Chalmers University of Technology

Nielsen, Jens B, 1962 (författare): Chalmers tekniska högskola,Chalmers University of Technology

(creator_code:org_t)

Elsevier BV, 2011
2011
Engelska.
Ingår i: Trends in Biotechnology. - : Elsevier BV. - 0167-7799 .- 1879-3096. ; 29:6, s. 251-258

Relaterad länk:: http://dx.doi.org/10...; visa fler...; https://research.cha...; https://doi.org/10.1...; visa färre...

Abstract Ämnesord

Stäng

Abundant microorganisms that inhabit the human intestine are implicated in health and disease. The gut microbiome has been studied with metagenomic tools, and over 3 million genes have been discovered, constituting a 'parts list' of this ecosystem; further understanding requires studies of the interacting parts. Mouse models have provided a glimpse into the microbiota and host interactions at metabolic and immunologic levels; however, to provide more insight, there is a need to generate mathematical models that can reveal genotype-phenotype relationships and provide scaffolds for integrated analyses. To this end, we propose the use of genome-scale metabolic models that have successfully been used in studying interactions between human hosts and microbes, as well as microbes in isolation and in communities.

Av författaren/redakt...: Karlsson, Fredri ...; Nookaew, Intawat ...; Petranovic Niels ...; Nielsen, Jens B, ...

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