Sökning: WFRF:(Petranovic Nielsen Dina 1975) > Symptomatic atheros...
Fältnamn | Indikatorer | Metadata |
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000 | 04483naa a2200445 4500 | |
001 | oai:gup.ub.gu.se/167208 | |
003 | SwePub | |
008 | 240528s2012 | |||||||||||000 ||eng| | |
009 | oai:research.chalmers.se:b3e00b23-b954-4637-a82a-4fd58d9bd81c | |
024 | 7 | a https://gup.ub.gu.se/publication/1672082 URI |
024 | 7 | a https://doi.org/10.1038/ncomms22662 DOI |
024 | 7 | a https://research.chalmers.se/publication/1672082 URI |
040 | a (SwePub)gud (SwePub)cth | |
041 | a eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Karlsson, Fredrik,d 1984u Chalmers tekniska högskola,Chalmers University of Technology4 aut0 (Swepub:cth)frekar |
245 | 1 0 | a Symptomatic atherosclerosis is associated with an altered gut metagenome |
264 | c 2012-12-04 | |
264 | 1 | b Springer Science and Business Media LLC,c 2012 |
338 | a electronic2 rdacarrier | |
520 | a Recent findings have implicated the gut microbiota as a contributor of metabolic diseases through the modulation of host metabolism and inflammation. Atherosclerosis is associated with lipid accumulation and inflammation in the arterial wall, and bacteria have been suggested as a causative agent of this disease. Here we use shotgun sequencing of the gut metagenome to demonstrate that the genus Collinsella was enriched in patients with symptomatic atherosclerosis, defined as stenotic atherosclerotic plaques in the carotid artery leading to cerebrovascular events, whereas Roseburia and Eubacterium were enriched in healthy controls. Further characterization of the functional capacity of the metagenomes revealed that patient gut metagenomes were enriched in genes encoding peptidoglycan synthesis and depleted in phytoene dehydrogenase; patients also had reduced serum levels of β-carotene. Our findings suggest that the gut metagenome is associated with the inflammatory status of the host and patients with symptomatic atherosclerosis harbor characteristic changes in the gut metagenome. | |
650 | 7 | a TEKNIK OCH TEKNOLOGIERx Industriell bioteknik0 (SwePub)2092 hsv//swe |
650 | 7 | a ENGINEERING AND TECHNOLOGYx Industrial Biotechnology0 (SwePub)2092 hsv//eng |
700 | 1 | a Fåk, Fridau Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Wallenberg Laboratory,Institute of Medicine, Department of Molecular and Clinical Medicine,University of Gothenburg4 aut0 (Swepub:gu)xfakfr |
700 | 1 | a Nookaew, Intawat,d 1977u Chalmers tekniska högskola,Chalmers University of Technology4 aut0 (Swepub:cth)intawat |
700 | 1 | a Tremaroli, Valentina,d 1978u Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Wallenberg Laboratory,Institute of Medicine, Department of Molecular and Clinical Medicine,University of Gothenburg4 aut0 (Swepub:gu)xtreva |
700 | 1 | a Fagerberg, Björn,d 1943u Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Wallenberg Laboratory,Institute of Medicine, Department of Molecular and Clinical Medicine,University of Gothenburg4 aut0 (Swepub:gu)xfagbj |
700 | 1 | a Petranovic Nielsen, Dina,d 1975u Chalmers tekniska högskola,Chalmers University of Technology4 aut0 (Swepub:cth)dinap |
700 | 1 | a Bäckhed, Fredrik,d 1973u Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Wallenberglaboratoriet,Institute of Medicine, Department of Molecular and Clinical Medicine,Wallenberg Laboratory,University of Gothenburg4 aut0 (Swepub:gu)xbafre |
700 | 1 | a Nielsen, Jens B,d 1962u Chalmers tekniska högskola,Chalmers University of Technology4 aut0 (Swepub:cth)nielsenj |
710 | 2 | a Chalmers tekniska högskolab Wallenberglaboratoriet4 org |
773 | 0 | t Nature Communicationsd : Springer Science and Business Media LLCg 3q 3x 2041-1723 |
856 | 4 | u https://gup.ub.gu.se/publication/167208x primaryx freey FULLTEXT |
856 | 4 | u https://www.nature.com/articles/ncomms2266.pdf |
856 | 4 | u http://publications.lib.chalmers.se/records/fulltext/local_167208.pdfx primaryx freey FULLTEXT |
856 | 4 8 | u https://gup.ub.gu.se/publication/167208 |
856 | 4 8 | u https://doi.org/10.1038/ncomms2266 |
856 | 4 8 | u https://research.chalmers.se/publication/167208 |
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