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Relationship between T-cell-dependent and T-cell-independent vaccines after neurotrauma : Can the response be predicted?
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- Ljunghill Hedberg, Anna (författare)
- Uppsala universitet,Infektionsmedicin
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- Pauksen, Karlis (författare)
- Uppsala universitet,Infektionsmedicin
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- Enblad, Per (författare)
- Uppsala universitet,Neurokirurgi
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- Larsson, Anders (författare)
- Uppsala universitet,Klinisk kemi
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- Sjölin, Jan (författare)
- Uppsala universitet,Infektionsmedicin
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(creator_code:org_t)
- 2022-06-15
- 2022
- Engelska.
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Ingår i: Human Vaccines & Immunotherapeutics. - : Taylor & Francis Group. - 2164-5515 .- 2164-554X. ; 18:5
- Relaterad länk:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Background: After trauma and central nervous system (CNS) injury, trauma-induced immune deficiency syndrome (TIDS) and CNS injury-induced immune deficiency syndrome (CIDS) may negatively affect responses to T-cell-dependent vaccines, such as pneumococcal conjugate vaccine (PCV) recommended after basilar fracture. This study (NCT02806284) aimed to investigate whether there after neurotrauma is a correlation between T-cell-dependent and independent vaccine responses and, thus, if B-cell activity is similarly depressed and whether the T-cell-dependent response is possible to predict.Method: Adult patients with basilar fracture (n = 33) and those undergoing pituitary gland surgery (n = 23) were within 10 days vaccinated with a T-cell-dependent vaccine against Haemophilus influenzae type b (Hib) and a T-cell-independent pneumococcal polysaccharide vaccine (PPSV). Samples reflecting the systemic inflammatory response and pre- and post-vaccination antibody levels after 3–6 weeks against Hib and PPSV were collected and determined by enzyme immunoassays.Results: High and significant correlations were detected in the responses to different pneumococcal serotypes, but none between the Hib and PPSV responses. No differences in trauma scores, C-reactive protein, IL-6, IL-10, pentraxin 3, fractalkine or calprotectin plasma concentrations or in ex vivo TNF-α, IL-6 or IL-10 responses to endotoxin were found between Hib vaccination responders and non-responders.Conclusions: There was no correlation between the pneumococcal responses and that to Hib, indicating that B-cell function is not similarly depressed as T-cell function. Grading of the trauma or parameters reflecting the innate immune response could not predict the T-cell-dependent vaccine response. There is a need of further studies evaluating the vaccine response after neurotrauma.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
Nyckelord
- Posttraumatic meningitis
- pneumococcal polysaccharide vaccine
- pneumococcal conjugate vaccine
- CNS injury-induced immune deficiency syndrome
- T-Cell function
- B-Cell function
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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