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FältnamnIndikatorerMetadata
00008112naa a2200649 4500
001oai:DiVA.org:umu-191358
003SwePub
008220114s2021 | |||||||||||000 ||eng|
009oai:DiVA.org:liu-183073
009oai:prod.swepub.kib.ki.se:148769705
009oai:DiVA.org:uu-468384
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1913582 URI
0247 a https://doi.org/10.1097/PCC.00000000000027872 DOI
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-1830732 URI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1487697052 URI
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4683842 URI
040 a (SwePub)umud (SwePub)liud (SwePub)kid (SwePub)uu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a for2 swepub-publicationtype
1001 a Ranta, Susannau Karolinska Institutet,Karolinska Inst, Dept Womens & Childrens Hlth, Childhood Canc Res Unit, Stockholm, Sweden.;Karolinska Univ Hosp, Astrid Lindgren Childrens Hosp, Pediat Oncol, Stockholm, Sweden.4 aut
2451 0a Icu admission in children with acute lymphoblastic leukemia in sweden: Prevalence, outcome, and risk factors
264 1a Philadelphia, PA, United States :b Lippincott Williams & Wilkins,c 2021
338 a print2 rdacarrier
500 a Funding Agencies: Swedish Childhood Cancer Foundation European Commission; Stockholm County Council (Medical Training and Research Agreement (ALF project)
520 a OBJECTIVES: Despite progress in the treatment of childhood acute lymphoblastic leukemia, severe complications are common, and the need of supportive care is high. We explored the cumulative prevalence, clinical risk factors, and outcomes of children with acute lymphoblastic leukemia, on first-line leukemia treatment in the ICUs in Sweden.DESIGN: A nationwide prospective register and retrospective chart review study.SETTING: Children with acute lymphoblastic leukemia were identified,and demographic and clinical data were obtained from the Swedish Childhood Cancer Registry. Data on intensive care were collected from the Swedish Intensive Care Registry. Data on patients with registered ICU admission in the Swedish Childhood Cancer Registry were supplemented through questionnaires to the pediatric oncology centers.PATIENTS: All 637 children 0-17.9 years old with acute lymphoblastic leukemia diagnosed between June 2008 and December 2016 in Sweden were included.INTERVENTIONS: None.MEASUREMENTS AND MAIN RESULTS: Twenty-eight percent of the children (178/637) were admitted to an ICU at least once. The Swedish Intensive Care Registry data were available for 96% of admissions (241/252). An ICU admission was associated with poor overall survival (hazard ratio, 3.25; 95% CI, 1.97-5.36; p ≤ 0.0001). ICU admissions occurred often during early treatment; 48% (85/178) were admitted to the ICU before the end of the first month of acute lymphoblastic leukemia treatment (induction therapy). Children with T-cell acute lymphoblastic leukemia or CNS leukemia had a higher risk of being admitted to the ICU in multivariable analyses, both for early admissions before the end of induction therapy and for all admissions during the study period.CONCLUSIONS: The need for intensive care in children with acute lymphoblastic leukemia, especially for children with T cell acute lymphoblastic leukemia and CNS leukemia, is high with most admissions occurring during early treatment.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Pediatrik0 (SwePub)302212 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Pediatrics0 (SwePub)302212 hsv//eng
653 a Children
653 a Intensive care
653 a Leukemia
653 a Prevalence
653 a Risk factors
7001 a Broman, Lars Mikaelu Karolinska Institutet,Karolinska Univ Hosp, ECMO Ctr Karolinska, Dept Pediat Perioperat Med & Intens Care, Stockholm, Sweden.;Karolinska Inst, Dept Physiol & Pharmacol, Stockholm, Sweden.4 aut
7001 a Abrahamsson, Jonasu Institution of Clinical Sciences, Department of Pediatrics, Sahlgrenska University Hospital, Gothenburg, Sweden,Sahlgrens Univ Hosp, Inst Clin Sci, Dept Pediat, Gothenburg, Sweden.4 aut
7001 a Berner, Jonasu Karolinska Institutet,Karolinska Univ Hosp, ECMO Ctr Karolinska, Dept Pediat Perioperat Med & Intens Care, Stockholm, Sweden.;Karolinska Inst, Dept Physiol & Pharmacol, Stockholm, Sweden.4 aut
7001 a Fläring, Urbanu Karolinska Institutet,Karolinska Univ Hosp, ECMO Ctr Karolinska, Dept Pediat Perioperat Med & Intens Care, Stockholm, Sweden.;Karolinska Inst, Dept Physiol & Pharmacol, Stockholm, Sweden.4 aut
7001 a Myrberg, Ida Hedu Karolinska Institutet,Karolinska Inst, Dept Womens & Childrens Hlth, Childhood Canc Res Unit, Stockholm, Sweden.4 aut
7001 a Kalzén, Håkanu Department of Anesthesia, Södertälje Hospital, Södertälje, Sweden; Department of Anaesthesia and Intensive Care, Karolinska Institutet at Danderyd Hospital (KIDS), Danderyd, Sweden,Södertälje Hosp, Dept Anesthesia, Södertälje, Sweden.;Karolinska Inst Danderyd Hosp KIDS, Dept Anaesthesia & Intens Care, Danderyd, Sweden.4 aut
7001 a Karlsson, Leneu Institution of Clinical Sciences, Department of Pediatrics, Sahlgrenska University Hospital, Gothenburg, Sweden.4 aut
7001 a Mellgren, Karinu Institution of Clinical Sciences, Department of Pediatrics, Sahlgrenska University Hospital, Gothenburg, Sweden.,Sahlgrens Univ Hosp, Inst Clin Sci, Dept Pediat, Gothenburg, Sweden.4 aut
7001 a Nilsson, Annau Karolinska Institutet,Karolinska Inst, Dept Womens & Childrens Hlth, Childhood Canc Res Unit, Stockholm, Sweden.;Karolinska Univ Hosp, Astrid Lindgren Childrens Hosp, Pediat Oncol, Stockholm, Sweden.4 aut
7001 a Norén-Nyström, Ulrikau Umeå universitet,Pediatrik,Umeå University, Sweden,Umeå Univ, Dept Clin Sci, Pediat, Umeå, Sweden.4 aut0 (Swepub:umu)kagr0007
7001 a Palle, Josefineu Department of Women's and Children's Health, Uppsala University and Pediatric Oncology, Uppsala University Hospital, Uppsala, Sweden,Umeå University, Sweden,Umeå Univ, Dept Clin Sci, Pediat, Umeå, Sweden.4 aut
7001 a Von Schewelov, Katarinau ECMO Centre Karolinska, Department of Pediatric Perioperative Medicine and Intensive Care, Karolinska University Hospital, Stockholm, Sweden,Karolinska Univ Hosp, ECMO Ctr Karolinska, Dept Pediat Perioperat Med & Intens Care, Stockholm, Sweden.4 aut
7001 a Svahn, Johan E.u Department of Pediatric Oncology, Skåne University Hospital, Lund University, Lund, Sweden,Lund Univ, Skane Univ Hosp, Dept Pediat Oncol, Lund, Sweden.4 aut
7001 a Törnudd, Lisau Linköpings universitet,Avdelningen för barns och kvinnors hälsa,Medicinska fakulteten,Region Östergötland, H.K.H. Kronprinsessan Victorias barn- och ungdomssjukhus,Linköping Univ Hosp, Dept Pediat, Linköping, Sweden.4 aut0 (Swepub:liu)listo21
7001 a Heyman, Matsu Karolinska Institutet,Karolinska Inst, Dept Womens & Childrens Hlth, Childhood Canc Res Unit, Stockholm, Sweden.4 aut
7001 a Harila-Saari, Arja H.u Uppsala universitet,Barnonkologisk och neurologisk forskning,Uppsala Univ Hosp, Pediat Oncol, Uppsala, Sweden.4 aut0 (Swepub:uu)arjha456
7102 a Karolinska Institutetb Karolinska Inst, Dept Womens & Childrens Hlth, Childhood Canc Res Unit, Stockholm, Sweden.;Karolinska Univ Hosp, Astrid Lindgren Childrens Hosp, Pediat Oncol, Stockholm, Sweden.4 org
7730 t Pediatric Critical Care Medicined Philadelphia, PA, United States : Lippincott Williams & Wilkinsg 22:12, s. 1050-1060q 22:12<1050-1060x 1529-7535x 1947-3893
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-191358
8564 8u https://doi.org/10.1097/PCC.0000000000002787
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-183073
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:148769705
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-468384

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