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APOE4 predicts amyl...
APOE4 predicts amyloid-β in cortical brain biopsy but not idiopathic normal pressure hydrocephalus
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Pyykkö, O. T. (författare)
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Helisalmi, S. (författare)
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Koivisto, A. M. (författare)
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Mölsä, J. A. A. (författare)
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Rummukainen, J. (författare)
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Nerg, O. (författare)
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- Alafuzoff, Irina (författare)
- Uppsala universitet,Molekylär och morfologisk patologi,Alafuzoff
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Savolainen, S. (författare)
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Soininen, H. (författare)
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Jääskeläinen, J. E. (författare)
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Rinne, J. (författare)
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Leinonen, V. (författare)
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Hiltunen, M. (författare)
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(creator_code:org_t)
- 2012-09-06
- 2012
- Engelska.
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Ingår i: Journal of Neurology, Neurosurgery and Psychiatry. - : BMJ. - 0022-3050 .- 1468-330X. ; 83:11, s. 1119-1124
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Objective: To investigate the association of apolipoprotein E (APOE) genotype, especially the APOE4 allele, to (1) idiopathic normal pressure hydrocephalus (iNPH) and (2) amyloid-β (Aβ) plaques in cortical brain biopsies of presumed NPH patients with and without a final clinical diagnosis of Alzheimer's disease (AD). Methods: 202 patients with presumed NPH were evaluated by intraventricular pressure monitoring and frontal cortical biopsy immunostained against Aβ (134 semiquantified by Aβ plaques/mm 2). The 202 patients and 687 cognitively healthy individuals were genotyped for APOE. The final clinical diagnoses in a median follow-up of 3.9 years were: 113 iNPH (94 shunt responsive, 16 shunt non-responsive, three not shunted); 36 AD (12 mixed iNPH + AD); 53 others. Results: The APOE genotypes distributed similarly in the 94 shunt responsive and 16 non-responsive iNPH patients and healthy controls. In multivariate analysis, the APOE4 allele correlated independently with Aβ plaques in the cortical biopsies (OR 8.7, 95% CI 3.6 to 20, p<0.001). The APOE4 allele in presumed NPH predicted later AD as follows: sensitivity 61%; specificity 77%; positive predictive value 37%; negative predictive value 90%. Conclusion: In presumed NPH patients, APOE4 associates independently with the presence of Aβ plaques in the frontal cortical biopsy. APOE4 is not a risk factor for iNPH and does not predict the response to shunt. Our data further support the view that the iNPH syndrome is a distinct dementing disease.
Nyckelord
- amyloid beta protein
- apolipoprotein E2
- apolipoprotein E3
- apolipoprotein E4
- adult
- age distribution
- aged
- Alzheimer disease
- amyloid plaque
- apolipoprotein E4 gene
- article
- brain biopsy
- brain ventricle peritoneum shunt
- controlled study
- differential diagnosis
- disease marker
- female
- follow up
- gait disorder
- gene
- genetic association
- genotype
- heterozygote
- human
- immunohistochemistry
- immunoreactivity
- intracranial pressure monitoring
- major clinical study
- male
- memory disorder
- normotensive hydrocephalus
- predictive value
- priority journal
- sensitivity and specificity
- sex difference
- treatment response
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Pyykkö, O. T.
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Helisalmi, S.
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Koivisto, A. M.
-
Mölsä, J. A. A.
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Rummukainen, J.
-
Nerg, O.
-
visa fler...
-
Alafuzoff, Irina
-
Savolainen, S.
-
Soininen, H.
-
Jääskeläinen, J. ...
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Rinne, J.
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Leinonen, V.
-
Hiltunen, M.
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visa färre...
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Uppsala universitet