Hyperosmolaric contrast agents in cartilage tomography may expose cartilage to overload-induced cell death.

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Fältnamn	Indikatorer	Metadata
000		04878naa a2200541 4500
001		oai:DiVA.org:umu-104954
003		SwePub
008		150616s2012 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1049542 URI
024	7	a https://doi.org/10.1016/j.jbiomech.2011.11.0492 DOI
040		a (SwePub)umu
041		a engb engb -1
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Turunen, Mikaelu Department of Applied Physics, University of Eastern Finland, Kuopio, Finland; Department of Clinical Physiology, Kuopio University Hospital, Kuopio, Finland4 aut
245	1 0	a Hyperosmolaric contrast agents in cartilage tomography may expose cartilage to overload-induced cell death.
264	1	b Elsevier,c 2012
338		a print2 rdacarrier
520		a In clinical arthrographic examination, strong hypertonic contrast agents are injected directly into the joint space. This may reduce the stiffness of articular cartilage, which is further hypothesized to lead to overload-induced cell death. We investigated the cell death in articular cartilage while the tissue was compressed in situ in physiological saline solution and in full strength hypertonic X-ray contrast agent Hexabrix(TM). Samples were prepared from bovine patellae and stored in Dulbecco's Modified Eagle's Medium overnight. Further, impact tests with or without creep were conducted for the samples with contact stresses and creep times changing from 1 MPa to 10 MPa and from 0 min to 15 min, respectively. Finally, depth-dependent cell viability was assessed with a confocal microscope. In order to characterize changes in the biomechanical properties of cartilage as a result of the use of Hexabrix™, stress-relaxation tests were conducted for the samples immersed in Hexabrix™ and phosphate buffered saline (PBS). Both dynamic and equilibrium modulus of the samples immersed in Hexabrix™ were significantly (p<0.05) lower than those of the samples immersed in PBS. Cartilage samples immersed in physiological saline solution showed load-induced cell death primarily in the superficial and middle zones. However, under high 8-10 MPa contact stresses, the samples immersed in full strength Hexabrix™ showed significantly (p<0.05) higher number of dead cells than the samples compressed in physiological saline, especially in the deep zone of cartilage. In conclusion, excessive loading stresses followed by tissue creep might increase the risk for chondrocyte death in articular cartilage when immersed in hypertonic X-ray contrast agent, especially in the deep zone of cartilage.
520		a
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Radiologi och bildbehandling0 (SwePub)302082 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Radiology, Nuclear Medicine and Medical Imaging0 (SwePub)302082 hsv//eng
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Ortopedi0 (SwePub)302112 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Orthopaedics0 (SwePub)302112 hsv//eng
653		a Articular cartilage
653		a Biomechanics
653		a Indentation
653		a Osteoarthritis
653		a Artrography
653		a Confacal microscope
653		a Constrast agent
653		a Osmotic pressure
653		a biomechanics
653		a biomekanik
653		a ortopedi
653		a Orthopaedics
653		a Radiology
653		a radiologi
700	1	a Töyräs, Juhau Department of Applied Physics, University of Eastern Finland, Kuopio, Finland; Department of Clinical Physiology, Kuopio University Hospital, Kuopio, Finland4 aut
700	1	a Lammi, Mikko,d 1961-u Department of Biosciences, University of Eastern Finland, Kuopio, Finland; Biocenter Kuopio, University of Eastern Finland, Kuopio, Finland,Chondrogenic and Osteogenic Differentiation Group4 aut0 (Swepub:umu)mila0077
700	1	a Jurvelin, Jukkau Department of Applied Physics, University of Eastern Finland, Kuopio, Finland4 aut
700	1	a Korhonen, Ramiu Department of Applied Physics, University of Eastern Finland, Kuopio, Finland4 aut
710	2	a Department of Applied Physics, University of Eastern Finland, Kuopio, Finland; Department of Clinical Physiology, Kuopio University Hospital, Kuopio, Finlandb Department of Biosciences, University of Eastern Finland, Kuopio, Finland; Biocenter Kuopio, University of Eastern Finland, Kuopio, Finland4 org
773	0	t Journal of Biomechanicsd : Elsevierg 45:3, s. 497-503q 45:3<497-503x 0021-9290x 1873-2380
856	4	u http://www.jbiomech.com/article/S0021-9290%2811%2900743-3/abstracty Article web page
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-104954
856	4 8	u https://doi.org/10.1016/j.jbiomech.2011.11.049

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Av författaren/redakt...: Turunen, Mikael; Töyräs, Juha; Lammi, Mikko, 19 ...; Jurvelin, Jukka; Korhonen, Rami

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MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Radiologi och bi ...

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