SwePub
Sök i LIBRIS databas

  Utökad sökning

WFRF:(Franklin C. S.)
 

Sökning: WFRF:(Franklin C. S.) > (2020-2024) > Being overweight in...

Being overweight in childhood, puberty, or early adulthood: Changing asthma risk in the next generation?

Johannessen, A. (författare)
Univ Bergen, Dept Global Publ Hlth & Primary Care, N-5021 Bergen, Norway;Haukeland Hosp, Dept Occupat Med, Bergen, Norway
Lønnebotn, M. (författare)
Univ Bergen, Dept Global Publ Hlth & Primary Care, N-5021 Bergen, Norway;Haukeland Hosp, Dept Occupat Med, Bergen, Norway
Calciano, L. (författare)
Univ Verona, Dept Diagnost & Publ Hlth, Unit Epidemiol & Med Stat, Verona, Italy
visa fler...
Benediktsdóttir, B. (författare)
Univ Iceland, Fac Med, Reykjavik, Iceland;Landspitali Univ Hosp, Dept Sleep, Reykjavik, Iceland
Bertelsen, R. J. (författare)
Univ Bergen, Dept Clin Sci, Bergen, Norway,Tartu Univ Hosp, Lung Clin, Tartu, Estonia
Bråbäck, Lennart (författare)
Umeå universitet,Avdelningen för hållbar hälsa,Dept Publ Hlth & Clin Med, Occupat & Environm Med, Umeå, Sweden
Dharmage, S. (författare)
Univ Melbourne, Sch Populat & Global Hlth, Allergy & Lung Hlth Unit, Melbourne, Vic, Australia
Franklin, Karl A (författare)
Umeå universitet,Kirurgi,Umeå Univ, Surg, Dept Surg & Perioperat Sci, Umeå, Sweden
Gislason, T. (författare)
Landspitali Univ Hosp, Dept Sleep, Reykjavik, Iceland
Holm, M. (författare)
Sahlgrens Univ Hosp, Dept Occupat & Environm Med, Gothenburg, Sweden
Janson, Christer (författare)
Uppsala universitet,Lung- allergi- och sömnforskning
Jarvis, D. (författare)
Imperial Coll, Natl Heart & Lung Inst, Fac Med, London, England
Jõgi, R. (författare)
Kim, Jeong-Lim (författare)
Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa,Institute of Medicine, School of Public Health and Community Medicine,Univ Gothenburg, Sahlgrenska Acad, Dept Publ Hlth & Community Med, Occupat & Environm Med, Gothenburg, Sweden
Kirkeleit, J. (författare)
Univ Bergen, Dept Global Publ Hlth & Primary Care, N-5021 Bergen, Norway
Lodge, C. (författare)
Univ Melbourne, Dept Populat Hlth, Melbourne, Vic, Australia
Malinovschi, Andrei, 1978- (författare)
Uppsala universitet,Klinisk fysiologi
Martinez-Moratalla, J. (författare)
CHUA, Serv Neurol, Serv Salud Castilla La Mancha SESCAM, Albacete, Spain
Nilsen, R. M. (författare)
Bergen Univ Coll, Dept Nursing, Bergen, Norway
Pereira-Vega, A. (författare)
Hosp Juan Ramon Jimenez, Pneumol Sect, Huelva, Spain
Real, F. G. (författare)
Univ Bergen, Dept Clin Sci, Bergen, Norway;Haukeland Hosp, Dept Obstet & Gynecol, Bergen, Norway
Schlünssen, V. (författare)
Aarhus Univ, Dept Publ Hlth, Aarhus, Denmark
Accordini, S. (författare)
Univ Verona, Dept Diagnost & Publ Hlth, Unit Epidemiol & Med Stat, Verona, Italy
Svanes, C. (författare)
Haukeland Hosp, Dept Occupat Med, Bergen, Norway;Univ Bergen, Dept Global Publ Hlth & Primary Care, Ctr Int Hlth, Bergen, Norway
visa färre...
 (creator_code:org_t)
Elsevier BV, 2020
2020
Engelska.
Ingår i: Journal of Allergy and Clinical Immunology. - : Elsevier BV. - 0091-6749 .- 1097-6825. ; 145:3
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • Background: Overweight status and asthma have increased during the last decades. Being overweight is a known risk factor for asthma, but it is not known whether it might also increase asthma risk in the next generation. Objective: We aimed to examine whether parents being overweight in childhood, adolescence, or adulthood is associated with asthma in their offspring. Methods: We included 6347 adult offspring (age, 18-52 years) investigated in the Respiratory Health in Northern Europe, Spain and Australia (RHINESSA) multigeneration study of 2044 fathers and 2549 mothers (age, 37-66 years) investigated in the European Community Respiratory Health Survey (ECRHS) study. Associations of parental overweight status at age 8 years, puberty, and age 30 years with offspring's childhood overweight status (potential mediator) and offspring's asthma with or without nasal allergies (outcomes) was analyzed by using 2-level logistic regression and 2-level multinomial logistic regression, respectively. Counterfactual-based mediation analysis was performed to establish whether observed associations were direct or indirect effects mediated through the offspring's own overweight status. Results: We found statistically significant associations between both fathers' and mothers' childhood overweight status and offspring's childhood overweight status (odds ratio, 2.23 [95% CI, 1.45-3.42] and 2.45 [95% CI, 1.86-3.22], respectively). We also found a statistically significant effect of fathers' onset of being overweight in puberty on offspring's asthma without nasal allergies (relative risk ratio, 2.31 [95% CI, 1.23-4.33]). This effect was direct and not mediated through the offspring's own overweight status. No effect on offspring's asthma with nasal allergies was found. Conclusion: Our findings suggest that metabolic factors long before conception can increase asthma risk and that male puberty is a time window of particular importance for offspring's health. © 2019 The Authors

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Immunology in the medical area (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Lungmedicin och allergi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Respiratory Medicine and Allergy (hsv//eng)

Nyckelord

Ageing Lungs in European Cohorts study
epidemiology
multilevel mediation model
offspring
parental risk factors
Ageing Lungs in European Cohorts study

Publikations- och innehållstyp

ref (ämneskategori)
art (ämneskategori)

Hitta via bibliotek

Till lärosätets databas

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy