Sökning: WFRF:(Franklin C. S.) > (2020-2024) > Being overweight in...
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000 | 07898naa a2200781 4500 | |
001 | oai:gup.ub.gu.se/289671 | |
003 | SwePub | |
008 | 240528s2020 | |||||||||||000 ||eng| | |
009 | oai:DiVA.org:umu-170419 | |
009 | oai:DiVA.org:uu-410139 | |
024 | 7 | a https://gup.ub.gu.se/publication/2896712 URI |
024 | 7 | a https://doi.org/10.1016/j.jaci.2019.08.0302 DOI |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1704192 URI |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4101392 URI |
040 | a (SwePub)gud (SwePub)umud (SwePub)uu | |
041 | a eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Johannessen, A.u Univ Bergen, Dept Global Publ Hlth & Primary Care, N-5021 Bergen, Norway;Haukeland Hosp, Dept Occupat Med, Bergen, Norway4 aut |
245 | 1 0 | a Being overweight in childhood, puberty, or early adulthood: Changing asthma risk in the next generation? |
264 | 1 | b Elsevier BV,c 2020 |
520 | a Background: Overweight status and asthma have increased during the last decades. Being overweight is a known risk factor for asthma, but it is not known whether it might also increase asthma risk in the next generation. Objective: We aimed to examine whether parents being overweight in childhood, adolescence, or adulthood is associated with asthma in their offspring. Methods: We included 6347 adult offspring (age, 18-52 years) investigated in the Respiratory Health in Northern Europe, Spain and Australia (RHINESSA) multigeneration study of 2044 fathers and 2549 mothers (age, 37-66 years) investigated in the European Community Respiratory Health Survey (ECRHS) study. Associations of parental overweight status at age 8 years, puberty, and age 30 years with offspring's childhood overweight status (potential mediator) and offspring's asthma with or without nasal allergies (outcomes) was analyzed by using 2-level logistic regression and 2-level multinomial logistic regression, respectively. Counterfactual-based mediation analysis was performed to establish whether observed associations were direct or indirect effects mediated through the offspring's own overweight status. Results: We found statistically significant associations between both fathers' and mothers' childhood overweight status and offspring's childhood overweight status (odds ratio, 2.23 [95% CI, 1.45-3.42] and 2.45 [95% CI, 1.86-3.22], respectively). We also found a statistically significant effect of fathers' onset of being overweight in puberty on offspring's asthma without nasal allergies (relative risk ratio, 2.31 [95% CI, 1.23-4.33]). This effect was direct and not mediated through the offspring's own overweight status. No effect on offspring's asthma with nasal allergies was found. Conclusion: Our findings suggest that metabolic factors long before conception can increase asthma risk and that male puberty is a time window of particular importance for offspring's health. © 2019 The Authors | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskapx Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi0 (SwePub)303022 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Health Sciencesx Public Health, Global Health, Social Medicine and Epidemiology0 (SwePub)303022 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Immunologi inom det medicinska området0 (SwePub)301102 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Immunology in the medical area0 (SwePub)301102 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Lungmedicin och allergi0 (SwePub)302192 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Respiratory Medicine and Allergy0 (SwePub)302192 hsv//eng |
653 | a Ageing Lungs in European Cohorts study | |
653 | a epidemiology | |
653 | a multilevel mediation model | |
653 | a offspring | |
653 | a parental risk factors | |
653 | a Ageing Lungs in European Cohorts study | |
700 | 1 | a Lønnebotn, M.u Univ Bergen, Dept Global Publ Hlth & Primary Care, N-5021 Bergen, Norway;Haukeland Hosp, Dept Occupat Med, Bergen, Norway4 aut |
700 | 1 | a Calciano, L.u Univ Verona, Dept Diagnost & Publ Hlth, Unit Epidemiol & Med Stat, Verona, Italy4 aut |
700 | 1 | a Benediktsdóttir, B.u Univ Iceland, Fac Med, Reykjavik, Iceland;Landspitali Univ Hosp, Dept Sleep, Reykjavik, Iceland4 aut |
700 | 1 | a Bertelsen, R. J.u Univ Bergen, Dept Clin Sci, Bergen, Norway,Tartu Univ Hosp, Lung Clin, Tartu, Estonia4 aut |
700 | 1 | a Bråbäck, Lennartu Umeå universitet,Avdelningen för hållbar hälsa,Dept Publ Hlth & Clin Med, Occupat & Environm Med, Umeå, Sweden4 aut0 (Swepub:umu)lebr0005 |
700 | 1 | a Dharmage, S.u Univ Melbourne, Sch Populat & Global Hlth, Allergy & Lung Hlth Unit, Melbourne, Vic, Australia4 aut |
700 | 1 | a Franklin, Karl Au Umeå universitet,Kirurgi,Umeå Univ, Surg, Dept Surg & Perioperat Sci, Umeå, Sweden4 aut0 (Swepub:umu)kafr0021 |
700 | 1 | a Gislason, T.u Landspitali Univ Hosp, Dept Sleep, Reykjavik, Iceland4 aut |
700 | 1 | a Holm, M.u Sahlgrens Univ Hosp, Dept Occupat & Environm Med, Gothenburg, Sweden4 aut |
700 | 1 | a Janson, Christeru Uppsala universitet,Lung- allergi- och sömnforskning4 aut0 (Swepub:uu)chrisjn |
700 | 1 | a Jarvis, D.u Imperial Coll, Natl Heart & Lung Inst, Fac Med, London, England4 aut |
700 | 1 | a Jõgi, R.4 aut |
700 | 1 | a Kim, Jeong-Limu Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa,Institute of Medicine, School of Public Health and Community Medicine,Univ Gothenburg, Sahlgrenska Acad, Dept Publ Hlth & Community Med, Occupat & Environm Med, Gothenburg, Sweden4 aut0 (Swepub:gu)xkimje |
700 | 1 | a Kirkeleit, J.u Univ Bergen, Dept Global Publ Hlth & Primary Care, N-5021 Bergen, Norway4 aut |
700 | 1 | a Lodge, C.u Univ Melbourne, Dept Populat Hlth, Melbourne, Vic, Australia4 aut |
700 | 1 | a Malinovschi, Andrei,d 1978-u Uppsala universitet,Klinisk fysiologi4 aut0 (Swepub:uu)anmal535 |
700 | 1 | a Martinez-Moratalla, J.u CHUA, Serv Neurol, Serv Salud Castilla La Mancha SESCAM, Albacete, Spain4 aut |
700 | 1 | a Nilsen, R. M.u Bergen Univ Coll, Dept Nursing, Bergen, Norway4 aut |
700 | 1 | a Pereira-Vega, A.u Hosp Juan Ramon Jimenez, Pneumol Sect, Huelva, Spain4 aut |
700 | 1 | a Real, F. G.u Univ Bergen, Dept Clin Sci, Bergen, Norway;Haukeland Hosp, Dept Obstet & Gynecol, Bergen, Norway4 aut |
700 | 1 | a Schlünssen, V.u Aarhus Univ, Dept Publ Hlth, Aarhus, Denmark4 aut |
700 | 1 | a Accordini, S.u Univ Verona, Dept Diagnost & Publ Hlth, Unit Epidemiol & Med Stat, Verona, Italy4 aut |
700 | 1 | a Svanes, C.u Haukeland Hosp, Dept Occupat Med, Bergen, Norway;Univ Bergen, Dept Global Publ Hlth & Primary Care, Ctr Int Hlth, Bergen, Norway4 aut |
710 | 2 | a Univ Bergen, Dept Global Publ Hlth & Primary Care, N-5021 Bergen, Norway;Haukeland Hosp, Dept Occupat Med, Bergen, Norwayb Univ Verona, Dept Diagnost & Publ Hlth, Unit Epidemiol & Med Stat, Verona, Italy4 org |
773 | 0 | t Journal of Allergy and Clinical Immunologyd : Elsevier BVg 145:3q 145:3x 0091-6749x 1097-6825 |
856 | 4 | u http://www.jacionline.org/article/S0091674919311728/pdf |
856 | 4 | u https://doi.org/10.1016/j.jaci.2019.08.030y Fulltext |
856 | 4 | u https://umu.diva-portal.org/smash/get/diva2:1428498/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print |
856 | 4 | u https://uu.diva-portal.org/smash/get/diva2:1433255/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print |
856 | 4 8 | u https://gup.ub.gu.se/publication/289671 |
856 | 4 8 | u https://doi.org/10.1016/j.jaci.2019.08.030 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-170419 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-410139 |
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