Sökning: WFRF:(Gontero Paolo) >
Association of pati...
-
D'Andrea, DavidMed Univ Vienna, Comprehens Canc Ctr, Dept Urol, Vienna, Austria.
(författare)
Association of patients' sex with treatment outcomes after intravesical bacillus Calmette-Guerin immunotherapy for T1G3/HG bladder cancer
- Artikel/kapitelEngelska2021
Förlag, utgivningsår, omfång ...
-
2021-03-13
-
Springer Nature,2021
-
electronicrdacarrier
Nummerbeteckningar
-
LIBRIS-ID:oai:DiVA.org:uu-470099
-
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-470099URI
-
https://doi.org/10.1007/s00345-021-03653-1DOI
Kompletterande språkuppgifter
-
Språk:engelska
-
Sammanfattning på:engelska
Ingår i deldatabas
Klassifikation
-
Ämneskategori:ref swepub-contenttype
-
Ämneskategori:art swepub-publicationtype
Anmärkningar
-
Purpose: To investigate the association of patients' sex with recurrence and disease progression in patients treated with intravesical bacillus Calmette-Guerin (BCG) for T1G3/HG urinary bladder cancer (UBC).Materials and methods: We analyzed the data of 2635 patients treated with adjuvant intravesical BCG for T1 UBC between 1984 and 2019. We accounted for missing data using multiple imputations and adjusted for covariate imbalance between males and females using inverse probability weighting (IPW). Crude and IPW-adjusted Cox regression analyses were used to estimate the hazard ratios (HR) with their 95% confidence intervals (CI) for the association of patients' sex with HG-recurrence and disease progression.Results: A total of 2170 (82%) males and 465 (18%) females were available for analysis. Overall, 1090 (50%) males and 244 (52%) females experienced recurrence, and 391 (18%) males and 104 (22%) females experienced disease progression. On IPW-adjusted Cox regression analyses, female sex was associated with disease progression (HR 1.25, 95%CI 1.01-1.56, p = 0.04) but not with recurrence (HR 1.06, 95%CI 0.92-1.22, p = 0.41). A total of 1056 patients were treated with adequate BCG. In these patients, on IPW-adjusted Cox regression analyses, patients' sex was not associated with recurrence (HR 0.99, 95%CI 0.80-1.24, p = 0.96), HG-recurrence (HR 1.00, 95%CI 0.78-1.29, p = 0.99) or disease progression (HR 1.12, 95%CI 0.78-1.60, p = 0.55).Conclusion: Our analysis generates the hypothesis of a differential response to BCG between males and females if not adequately treated. Further studies should focus on sex-based differences in innate and adaptive immune system and their association with BCG response.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
-
Soria, FrancescoUniv Studies Turin, AOU Citta Salute & Sci Torino, Div Urol, Turin, Italy.
(författare)
-
Grotenhuis, Anne J.Radboud Univ Nijmegen, Med Ctr, Dept Urol, Nijmegen, Netherlands.
(författare)
-
Cha, Eugene K.Cornell Univ, Weill Med Coll, Dept Urol, New York, NY USA.;Mem Sloan Kettering Canc Ctr, Dept Urol, 1275 York Ave, New York, NY 10021 USA.
(författare)
-
Malats, NuriaSpanish Natl Canc Res Ctr CNIO, Genet & Mol Epidemiol Grp, Madrid, Spain.
(författare)
-
Di Stasi, SavinoUniv Rome, Policlin Tor Vergata, Dept Urol, Rome, Italy.
(författare)
-
Joniau, StevenUniv Hosp Leuven, Dept Urol, Oncol & Reconstruct Urol, Leuven, Belgium.
(författare)
-
Cai, TommasoSanta Chiara Hosp, Dept Urol, Trento, Italy.
(författare)
-
van Rhijn, Bas W. G.Antoni von Leeuwenhoek Hosp, Netherlands Canc Inst, Dept Surg Oncol Urol, Amsterdam, Netherlands.
(författare)
-
Irani, JaquesUniv Poitiers, Ctr Univ La Miletrie, Dept Urol, Poitiers, France.
(författare)
-
Karnes, JeffreyMayo Clin, Dept Urol, Rochester, MN USA.
(författare)
-
Varkarakis, John
(författare)
-
Baniel, JackRabin Med Ctr, Dept Urol, Tel Aviv, Israel.
(författare)
-
Palou, JoanUniv Athens, Sismanoglio Hosp, Dept Urol, Athens, Greece.;Univ Barcelona, Dept Urol, Fundacio Puigvert, Barcelona, Spain.
(författare)
-
Babjuk, MarekUniv Praha, Motol Hosp, Dept Urol, Prague, Czech Republic.
(författare)
-
Spahn, MartinUniv Hosp Wuerzburg, Dept Urol, Wuertzburg, Germany.
(författare)
-
Ardelt, PeterUniv Klin Freiburg, Dept Urol, Freiburg, Germany.
(författare)
-
Colombo, RenzoUniv Vita Salute, Dept Urol, Osped S Raffaele, Milan, Italy.
(författare)
-
Serretta, VincenzoUniv Palermo, Dept Surg Oncol & Stomatol Sci, Palermo, Italy.
(författare)
-
Dalbagni, GuidoMem Sloan Kettering Canc Ctr, Dept Urol, 1275 York Ave, New York, NY 10021 USA.
(författare)
-
Gontero, PaoloUniv Studies Turin, AOU Citta Salute & Sci Torino, Div Urol, Turin, Italy.
(författare)
-
Bartoletti, RiccardoUniv Pisa, Dept Translat Res & New Technol, Pisa, Italy.
(författare)
-
Larre, StephaneCHU Reims, Dept Urol, Reims, France.
(författare)
-
Malmström, Per-UnoUppsala universitet,Urologkirurgi(Swepub:uu)perunoms
(författare)
-
Sylvester, RichardEuropean Assoc Urol Nonmuscle Invas Bladder Canc, Brussels, Belgium.
(författare)
-
Shariat, Shahrokh F.Med Univ Vienna, Comprehens Canc Ctr, Dept Urol, Vienna, Austria.;Cornell Univ, Weill Med Coll, Dept Urol, New York, NY USA.;Mem Sloan Kettering Canc Ctr, Dept Urol, 1275 York Ave, New York, NY 10021 USA.;Charles Univ Prague, Fac Med 2, Dept Urol, Prague, Czech Republic.;IM Sechenov First Moscow State Med Univ, Inst Urol & Reprod Hlth, Moscow, Russia.;Univ Jordan, Dept Urol, Amman, Jordan.;European Assoc Urol Res Fdn, Arnhem, Netherlands.
(författare)
-
Med Univ Vienna, Comprehens Canc Ctr, Dept Urol, Vienna, Austria.Univ Studies Turin, AOU Citta Salute & Sci Torino, Div Urol, Turin, Italy.
(creator_code:org_t)
Sammanhörande titlar
-
Ingår i:World journal of urology: Springer Nature39:9, s. 3337-33440724-49831433-8726
Internetlänk
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
D'Andrea, David
-
Soria, Francesco
-
Grotenhuis, Anne ...
-
Cha, Eugene K.
-
Malats, Nuria
-
Di Stasi, Savino
-
visa fler...
-
Joniau, Steven
-
Cai, Tommaso
-
van Rhijn, Bas W ...
-
Irani, Jaques
-
Karnes, Jeffrey
-
Varkarakis, John
-
Baniel, Jack
-
Palou, Joan
-
Babjuk, Marek
-
Spahn, Martin
-
Ardelt, Peter
-
Colombo, Renzo
-
Serretta, Vincen ...
-
Dalbagni, Guido
-
Gontero, Paolo
-
Bartoletti, Ricc ...
-
Larre, Stephane
-
Malmström, Per-U ...
-
Sylvester, Richa ...
-
Shariat, Shahrok ...
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Urologi och njur ...
- Artiklar i publikationen
-
World journal of ...
- Av lärosätet
-
Uppsala universitet