WFRF:(Isaksson Olle 1943)
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Disproportional skeletal growth and markedly decreased bone mineral content in growth hormone receptor -/- mice.
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- Sjögren, Klara, 1970 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för internmedicin,Institute of Internal Medicine, Dept of Medicine
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- Bohlooly-Yeganeh, Mohammad, 1966 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för fysiologi och farmakologi, Avdelningen för fysiologi,Institute of Physiology and Pharmacology, Dept of Physiology
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- Olsson, Bob, 1969 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för fysiologi och farmakologi, Avdelningen för fysiologi,Institute of Physiology and Pharmacology, Dept of Physiology
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- Coschigano, Karen T (author)
- Mohan, Subburaman (author)
- Baumann, G (author)
- Kopchick, John J (author)
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- (creator_code:org_t)
- Elsevier BV, 2000
- 2000
- English.
- In: Biochemical and biophysical research communications. - : Elsevier BV. - 0006-291X. ; 267:2, s. 603-8
- Journal article (peer-reviewed)
Abstract
Subject headings
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- Growth hormone (GH) is important for skeletal growth as well as for a normal bone metabolism in adults. The skeletal growth and adult bone metabolism was studied in mice with an inactivated growth hormone receptor (GHR) gene. The lengths of femur, tibia, and crown-rump were, as expected, decreased in GHR-/- mice. Unexpectedly, GHR-/- mice displayed disproportional skeletal growth reflected by decreased femur/crown-rump and femur/tibia ratios. GHR-/- mice demonstrated decreased width of the growth plates in the long bones and disturbed ossification of the proximal tibial epiphysis. Furthermore, the area bone mineral density (BMD) as well as the bone mineral content (BMC)/body weight were markedly decreased in GHR-/- mice. The decrease in BMC in GHR-/- mice was not due to decreased trabecular volumetric BMD but to a decreased cross-sectional cortical bone area In conclusion, GHR-/- mice demonstrate disproportional skeletal growth and markedly decreased bone mineral content.
Keyword
- Animals
- Base Sequence
- Biological Markers
- blood
- Bone Density
- genetics
- physiology
- Bone Development
- genetics
- physiology
- DNA Primers
- genetics
- Femur
- growth & development
- Growth Hormone
- physiology
- Insulin-Like Growth Factor I
- genetics
- metabolism
- Male
- Mice
- Mice
- Knockout
- Organ Size
- Organ Specificity
- RNA
- Messenger
- genetics
- metabolism
- Receptors
- Somatotropin
- deficiency
- genetics
- Tibia
- growth & development
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- ref (subject category)
- art (subject category)
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