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Quality of life in Klinefelter patients on testosterone replacement therapy compared to healthy controls: an observational study on the impact of psychological distress, personality traits, and coping strategies
- Fabrazzo, M. (författare)
- Accardo, G. (författare)
- Abbondandolo, I. (författare)
- visa fler...
- Goglia, G. (författare)
- Sampogna, G. (författare)
- Catapano, F. (författare)
- Giugliano, D. (författare)
- Pasquali, D. (författare)
- visa färre...
- (creator_code:org_t)
- 2020-08-31
- 2021
- Engelska.
- Ingår i: Journal of Endocrinological Investigation. - : Springer Science and Business Media LLC. - 0391-4097 .- 1720-8386. ; 44:5, s. 1053-1063
- Tidskriftsartikel (refereegranskat)
Abstract
Ämnesord
Stäng
- Purpose We aimed to verify if 1 year-testosterone-replacement therapy could produce a psychopathological recovery and a satisfactory quality of life in Klinefelter syndrome (KS) patients compared to matched healthy controls. Further, we analyzed personality traits and coping strategies, an issue not yet examined in androgen-treated KS patients. We also enquired whether any of the sociodemographic and psychological variables might predict a patient's general and sexual life satisfaction. Methods The Quality of Life Enjoyment and Satisfaction Questionnaire and the Temperament and Character Inventory-Revised were administered to both 23 KS patients and matched healthy subjects. Psychopathology was investigated by the Symptom Checklist-90-Revised (SCL-90-R) and the Mini-mental State Examination. The COPE Inventory was used to identify cognitive and behavioral strategies to manage disease-related distress. Results In testosterone-treated KS patients, when compared with controls, SCL-90-R subscales analysis evidenced high psychological distress, mainly presented as obsessive thoughts, hanger-hostility, phobias, and psychoticism. Self-directedness and self-transcendence, along with the prevalent use ofemotion-focusedcoping strategies, outlined the personality of our KS patients. Depression and somatization proved to be predictors of general life dissatisfaction. Depression, anger-hostility, and paranoid ideation, instead, emerged as predictors of sexual life dissatisfaction. Conclusion Endocrinologists should cooperate with mental health providers to foster a better outcome of the disease in KS patients.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Nyckelord
- Klinefelter syndrome
- Genetic disorder
- Quality of life
- Testosterone
- replacement therapy
- Personality traits
- Coping strategies
- improves sexual function
- male hypogonadism
- mental-health
- elderly-men
- adult men
- society
- adolescents
- undecanoate
- adaptation
- parameters
- Endocrinology & Metabolism
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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- Av författaren/redakt...
- Fabrazzo, M.
- Accardo, G.
- Abbondandolo, I.
- Goglia, G.
- Esposito, Daniel ...
- Sampogna, G.
- visa fler...
- Catapano, F.
- Giugliano, D.
- Pasquali, D.
- visa färre...
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- Göteborgs universitet
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