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The Effect of Dieta...
The Effect of Dietary Nitrate on the Oral Microbiome and Salivary Biomarkers in Individuals with High Blood Pressure.
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- du Toit, Lisa (författare)
- School of Health Professions, Faculty of Health, University of Plymouth, Plymouth, United Kingdom.
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- Sundqvist, Michaela L (författare)
- Gymnastik- och idrottshögskolan,Institutionen för fysiologi, nutrition och biomekanik
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- Redondo-Rio, Alvaro (författare)
- Institute for Research in Biomedicine (IRB Barcelona), Barcelona, Spain; Barcelona Supercomputing Centre (BSC-CNS), Barcelona, Spain.
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- Brookes, Zöe (författare)
- Peninsula Dental School, Faculty of Health, University of Plymouth, Plymouth, United Kingdom.
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- Casas-Agustench, Patricia (författare)
- School of Health Professions, Faculty of Health, University of Plymouth, Plymouth, United Kingdom.
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- Hickson, Mary (författare)
- School of Health Professions, Faculty of Health, University of Plymouth, Plymouth, United Kingdom.
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- Benavente, Alicia (författare)
- Institute for Research in Biomedicine (IRB Barcelona), Barcelona, Spain; Barcelona Supercomputing Centre (BSC-CNS), Barcelona, Spain.
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- Montagut, Gemma (författare)
- Institute for Research in Biomedicine (IRB Barcelona), Barcelona, Spain; Barcelona Supercomputing Centre (BSC-CNS), Barcelona, Spain.
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- Weitzberg, Eddie (författare)
- Pharmacology and Physiology Department, Karolinska Institute, Stockholm, Sweden.
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- Gabaldón, Toni (författare)
- Institute for Research in Biomedicine (IRB Barcelona), Barcelona, Spain; Barcelona Supercomputing Centre (BSC-CNS), Barcelona, Spain; Catalan Institution for Research and Advanced Studies (ICREA), Barcelona, Spain; CIBER de Enfermedades Infecciosas, Instituto de Salud Carlos III, Barcelona, Spain.
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- Lundberg, Jon O (författare)
- Pharmacology and Physiology Department, Karolinska Institute, Stockholm, Sweden.
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- Bescos, Raul (författare)
- School of Health Professions, Faculty of Health, University of Plymouth, Plymouth, United Kingdom.
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School of Health Professions, Faculty of Health, University of Plymouth, Plymouth, United Kingdom Institutionen för fysiologi, nutrition och biomekanik (creator_code:org_t)
- 2024
- 2024
- Engelska.
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Ingår i: Journal of Nutrition. - : Elsevier. - 0022-3166 .- 1541-6100.
- Relaterad länk:
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https://doi.org/10.1...
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https://gih.diva-por... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- BACKGROUND: Green leafy vegetables (GLV) contain inorganic nitrate, an anion with potential prebiotic effects on the oral microbiome. However, it remains unclear whether GLV and pharmacological supplementation [potassium nitrate (PN)] with a nitrate salt induce similar effects on the oral microbiome.OBJECTIVES: This study aimed to compare the effect of GLV with PN supplementation on the oral microbiome composition and salivary biomarkers in individuals with high blood pressure.METHODS: Seventy individuals were randomly allocated to 3 different groups to follow a 5-wk dietary intervention. Group 1 consumed 300 mg/d of nitrate in form of GLV. Group 2 consumed pills with 300 mg/d of PN and low-nitrate vegetables. Group 3 consumed pills with potassium chloride (placebo: PLAC) and low-nitrate vegetables. The oral microbiome composition and salivary biomarkers of oral health were analyzed before and after the dietary intervention.RESULTS: The GLV and PN groups showed similar microbial changes, probably nitrate-dependent, including an increase in the abundance of Neisseria, Capnocytophaga, Campylobacter species, and a decrease in Veillonella, Megasphaera, Actinomyces, and Eubacterium species after the treatment. Increased abundance of Rothia species, and reduced abundance of Streptococcus, Prevotella, Actinomyces, and Mogibacterium species were observed in the GLV group, which could be nitrate-independent. GLV and PN treatments increased salivary pH, but only GLV treatment showed an increase in the salivary buffering capacity and a reduction of lactate.CONCLUSION: The combination of nitrate-dependent and nitrate-independent microbial changes in the GLV group has a stronger effect to potentially improve oral health biomarkers compared with PN.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Odontologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Dentistry (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Näringslära (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nutrition and Dietetics (hsv//eng)
Nyckelord
- leafy green vegetables
- microbiome
- nitrate
- nitric oxide
- nitrite
- oral health
- Medicin/Teknik
- Medicine/Technology
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
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du Toit, Lisa
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Sundqvist, Micha ...
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Redondo-Rio, Alv ...
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Brookes, Zöe
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Casas-Agustench, ...
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Hickson, Mary
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visa fler...
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Benavente, Alici ...
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Montagut, Gemma
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Weitzberg, Eddie
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Gabaldón, Toni
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Lundberg, Jon O
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Bescos, Raul
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Odontologi
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Hälsovetenskap
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och Näringslära
- Artiklar i publikationen
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Journal of Nutri ...
- Av lärosätet
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Gymnastik- och idrottshögskolan