Cumulative Burden of Colorectal Cancer Associated Genetic Variants Is More Strongly Associated With Early-Onset vs Late-Onset Cancer

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Fältnamn	Indikatorer	Metadata
000		21319naa a2202029 4500
001		oai:DiVA.org:uu-419394
003		SwePub
008		200910s2020 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
009		oai:DiVA.org:umu-193623
009		oai:prod.swepub.kib.ki.se:143324808
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4193942 URI
024	7	a https://doi.org/10.1053/j.gastro.2019.12.0122 DOI
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1936232 URI
024	7	a http://kipublications.ki.se/Default.aspx?queryparsed=id:1433248082 URI
040		a (SwePub)uud (SwePub)umud (SwePub)ki
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Archambault, Alexi N.u NYU, Div Epidemiol, Dept Populat Hlth, Sch Med, New York, NY USA.,Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, 1124 Columbia St, Seattle, WA 98104 USA.4 aut
245	1 0	a Cumulative Burden of Colorectal Cancer Associated Genetic Variants Is More Strongly Associated With Early-Onset vs Late-Onset Cancer
264	1	b Elsevier BV,c 2020
338		a print2 rdacarrier
520		a BACKGROUND & AIMS: Early-onset colorectal cancer (CRC, in persons younger than 50 years old) is increasing in incidence; yet, in the absence of a family history of CRC, this population lacks harmonized recommendations for prevention. We aimed to determine whether a polygenic risk score (PRS) developed from 95 CRC-associated common genetic risk variants was associated with risk for early-onset CRC.METHODS: We studied risk for CRC associated with a weighted PRS in 12,197 participants younger than 50 years old vs 95,865 participants 50 years or older. PRS was calculated based on single nucleotide polymorphisms associated with CRC in a large-scale genome-wide association study as of January 2019. Participants were pooled from 3 large consortia that provided clinical and genotyping data: the Colon Cancer Family Registry, the Colorectal Transdisciplinary Study, and the Genetics and Epidemiology of Colorectal Cancer Consortium and were all of genetically defined European descent. Findings were replicated in an independent cohort of 72,573 participants.RESULTS: Overall associations with CRC per standard deviation of PRS were significant for early-onset cancer, and were stronger compared with late-onset cancer (P for interaction = .01); when we compared the highest PRS quartile with the lowest, risk increased 3.7-fold for early-onset CRC (95% CI 3.28-4.24) vs 2.9-fold for late-onset CRC (95% CI 2.80-3.04). This association was strongest for participants without a first-degree family history of CRC (P for interaction = 5.61 x 10(-5)). When we compared the highest with the lowest quartiles in this group, risk increased 4.3-fold for early-onset CRC (95% CI 3.61-5.01) vs 2.9-fold for late-onset CRC (95% CI 2.70-3.00). Sensitivity analyses were consistent with these findings.CONCLUSIONS: In an analysis of associations with CRC per standard deviation of PRS, we found the cumulative burden of CRC-associated common genetic variants to associate with early-onset cancer, and to be more strongly associated with early-onset than late-onset cancer, particularly in the absence of CRC family history. Analyses of PRS, along with environmental and lifestyle risk factors, might identify younger individuals who would benefit from preventive measures.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Gastroenterologi0 (SwePub)302132 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Gastroenterology and Hepatology0 (SwePub)302132 hsv//eng
653		a Colon Cancer
653		a SNP
653		a Penetrance
653		a EOCRC
700	1	a Su, Yu-Ruu Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, 1124 Columbia St, Seattle, WA 98104 USA.4 aut
700	1	a Jeon, Jihyounu Univ Michigan, Dept Epidemiol, Ann Arbor, MI 48109 USA.,Univ Melbourne, Melbourne Sch Populat & Global Hlth, Ctr Biostat & Epidemiol, Melbourne, Vic, Australia.;Canc Council Victoria, Canc Epidemiol & Intelligence Div, Melbourne, Vic, Australia.,NCI, Div Canc Epidemiol & Genet, NIH, Bethesda, MD 20892 USA.,WHO, Int Agcy Res Canc, Nutr & Metab Sect, Lyon, France.,Univ Washington, Sch Publ Hlth, Dept Epidemiol, Seattle, WA 98195 USA.,Wageningen Univ & Res, Div Human Nutr & Hlth, Wageningen, Netherlands.,Harvard Univ, Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA.,Amer Canc Soc, Behav & Epidemiol Res Grp, Atlanta, GA USA.4 aut
700	1	a Thomas, Mintau Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, 1124 Columbia St, Seattle, WA 98104 USA.4 aut
700	1	a Lin, Yiu Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, 1124 Columbia St, Seattle, WA 98104 USA.4 aut
700	1	a Conti, David V.u Univ Southern Calif, USC Norris Comprehens Canc Ctr, Keck Sch Med, Dept Prevent Med, Los Angeles, CA 90007 USA.4 aut
700	1	a Win, Aung Kou Univ Melbourne, Melbourne Sch Populat & Global Hlth, Ctr Biostat & Epidemiol, Melbourne, Vic, Australia.4 aut
700	1	a Sakoda, Lori C.u Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, 1124 Columbia St, Seattle, WA 98104 USA.;Kaiser Permanente Northern Calif, Div Res, Oakland, CA USA.4 aut
700	1	a Lansdorp-Vogelaar, Irisu Erasmus MC, Univ Med Ctr, Dept Publ Hlth, Rotterdam, Netherlands.4 aut
700	1	a Peterse, Elisabeth F. P.u Erasmus MC, Univ Med Ctr, Dept Publ Hlth, Rotterdam, Netherlands.4 aut
700	1	a Zauber, Ann G.u Mem Sloan Kettering Canc Ctr, Dept Epidemiol & Biostat, New York, NY 10021 USA.4 aut
700	1	a Duggan, Davidu Translat Genom Res Inst, Phoenix, AZ USA.,Harvard Med Sch, Boston, MA 02115 USA.;Massachusetts Gen Hosp, Clin & Translat Epidemiol Unit, Boston, MA USA.;Harvard Univ, Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA.,Univ Cambridge, Dept Publ Hlth & Primary Care, Cambridge, England.,Univ Leeds, Leeds Inst Canc & Pathol, Leeds, W Yorkshire, England.,Univ Melbourne, Melbourne Sch Populat & Global Hlth, Ctr Biostat & Epidemiol, Melbourne, Vic, Australia.;Univ Melbourne, Dept Clin Pathol, Colorectal Oncogenom Grp, Parkville, Vic, Australia.;Royal Melbourne Hosp, Genom Med & Family Canc Clin, Parkville, Vic, Australia.;Univ Melbourne, Ctr Canc Res, Victorian Comprehens Canc Ctr, Parkville, Vic, Australia.,Karolinska Inst, Inst Environm Med, Stockholm, Sweden.,Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, 1124 Columbia St, Seattle, WA 98104 USA.4 aut
700	1	a Holowatyj, Andreana N.u Univ Utah, Huntsman Canc Inst, Salt Lake City, UT USA.;Univ Utah, Dept Populat Hlth Sci, Salt Lake City, UT USA.4 aut
700	1	a Huyghe, Jeroen R.u Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, 1124 Columbia St, Seattle, WA 98104 USA.4 aut
700	1	a Brenner, Hermannu German Canc Res Ctr, Div Clin Epidemiol & Aging Res, Heidelberg, Germany.;German Canc Res Ctr, Div Prevent Oncol, Heidelberg, Germany.;Natl Ctr Tumor Dis NCT, Heidelberg, Germany.;German Canc Res Ctr, German Canc Consortium DKTK, Heidelberg, Germany.4 aut
700	1	a Cotterchio, Michelleu Canc Care Ontario, Populat Hlth & Prevent, Toronto, ON, Canada.4 aut
700	1	a Bezieau, Stephaneu CHU Nantes, Serv Genet Med, Nantes, France.4 aut
700	1	a Schmit, Stephanie L.u Karolinska Institutet4 aut
700	1	a Edlund, Christopher K.u Univ Southern Calif, USC Norris Comprehens Canc Ctr, Keck Sch Med, Dept Prevent Med, Los Angeles, CA 90007 USA.4 aut
700	1	a Southey, Melissa C.u Univ Melbourne, Genet Epidemiol Lab, Dept Pathol, Melbourne, Vic, Australia.4 aut
700	1	a MacInnis, Robert J.u Univ Melbourne, Melbourne Sch Populat & Global Hlth, Ctr Biostat & Epidemiol, Melbourne, Vic, Australia.;Canc Council Victoria, Canc Epidemiol & Intelligence Div, Melbourne, Vic, Australia.4 aut
700	1	a Campbell, Peter T.u Amer Canc Soc, Behav & Epidemiol Res Grp, Atlanta, GA USA.4 aut
700	1	a Chang-Claude, Jennyu German Canc Res Ctr, Div Canc Epidemiol, Heidelberg, Germany.;UCCH, Univ Med Ctr Hamburg Eppendorf, Hamburg, Germany.4 aut
700	1	a Slattery, Martha L.u Univ Utah, Dept Internal Med, Salt Lake City, UT 84112 USA.4 aut
700	1	a Chan, Andrew T.u Massachusetts Gen Hosp, Div Gastroenterol, Boston, MA 02114 USA.;Harvard Med Sch, Boston, MA 02115 USA.;Brigham & Womens Hosp, Channing Div Network Med, 75 Francis St, Boston, MA 02115 USA.;Massachusetts Gen Hosp, Clin & Translat Epidemiol Unit, Boston, MA USA.;Broad Inst MIT & Harvard, Cambridge, MA 02142 USA.;Harvard Univ, Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA.;Harvard Univ, Harvard TH Chan Sch Publ Hlth, Dept Immunol & Infect Dis, Boston, MA 02115 USA.4 aut
700	1	a Joshi, Amit D.u Harvard Med Sch, Boston, MA 02115 USA.;Massachusetts Gen Hosp, Clin & Translat Epidemiol Unit, Boston, MA USA.;Harvard Univ, Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA.4 aut
700	1	a Song, Mingyangu Harvard Univ, Harvard TH Chan Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA.4 aut
700	1	a Cao, Yinu Harvard Med Sch, Boston, MA 02115 USA.;Massachusetts Gen Hosp, Clin & Translat Epidemiol Unit, Boston, MA USA.;Washington Univ, Div Publ Hlth Sci, Dept Surg, St Louis, MO 63110 USA.4 aut
700	1	a Woods, Michael O.u Mem Univ Newfoundland, Discipline Genet, St John, NF, Canada.4 aut
700	1	a White, Emilyu Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, 1124 Columbia St, Seattle, WA 98104 USA.;Univ Washington, Sch Publ Hlth, Dept Epidemiol, Seattle, WA 98195 USA.4 aut
700	1	a Weinstein, Stephanie J.u NCI, Div Canc Epidemiol & Genet, NIH, Bethesda, MD 20892 USA.4 aut
700	1	a Ulrich, Cornelia M.u Univ Utah, Huntsman Canc Inst, Salt Lake City, UT USA.;Univ Utah, Dept Populat Hlth Sci, Salt Lake City, UT USA.4 aut
700	1	a Hoffmeister, Michaelu German Canc Res Ctr, Div Clin Epidemiol & Aging Res, Heidelberg, Germany.4 aut
700	1	a Bien, Stephanie A.u Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, 1124 Columbia St, Seattle, WA 98104 USA.4 aut
700	1	a Harrison, Tabitha A.u Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, 1124 Columbia St, Seattle, WA 98104 USA.4 aut
700	1	a Hampe, Jochenu Tech Univ Dresden, Univ Hosp Dresden, Dept Med 1, Dresden, Germany.4 aut
700	1	a Li, Christopher I.u Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, 1124 Columbia St, Seattle, WA 98104 USA.4 aut
700	1	a Schafmayer, Clemensu Univ Hosp Schleswig Holstein, Dept Gen & Thorac Surg, Campus Kiel, Kiel, Germany.4 aut
700	1	a Offit, Kennethu Mem Sloan Kettering Canc Ctr, Dept Med, Clin Genet Serv, 1275 York Ave, New York, NY 10021 USA.;Weill Cornell Med Coll, Dept Med, New York, NY USA.4 aut
700	1	a Pharoah, Paul D.u Univ Cambridge, Dept Publ Hlth & Primary Care, Cambridge, England.4 aut
700	1	a Moreno, Victoru Catalan Inst Oncol IDIBELL, Canc Prevent & Control Program, Barcelona, Spain.;CIBERESP, Madrid, Spain.;Univ Barcelona, Fac Med, Dept Clin Sci, Barcelona, Spain.4 aut
700	1	a Lindblom, Annikau Karolinska Institutet4 aut
700	1	a Wolk, Alicjau Karolinska Institutet4 aut0 (Swepub:uu)alwol516
700	1	a Wu, Anna H.u Univ Southern Calif, USC Norris Comprehens Canc Ctr, Keck Sch Med, Dept Prevent Med, Los Angeles, CA 90007 USA.,Ohio State Univ, Dept Internal Med, Div Human Genet, Ctr Comprehens Canc, Columbus, OH 43210 USA.4 aut
700	1	a Li, Liu Univ Virginia, Dept Family Med, Charlottesville, VA USA.,Univ Melbourne, Melbourne Sch Populat & Global Hlth, Ctr Biostat & Epidemiol, Melbourne, Vic, Australia.;Canc Council Victoria, Canc Epidemiol & Intelligence Div, Melbourne, Vic, Australia.,Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, 1124 Columbia St, Seattle, WA 98104 USA.4 aut
700	1	a Gunter, Marc J.u WHO, Int Agcy Res Canc, Nutr & Metab Sect, Lyon, France.4 aut
700	1	a Gsur, Andreau Med Univ Vienna, Dept Med 1, Inst Canc Res, Vienna, Austria.4 aut
700	1	a Keku, Temitope O.u Univ N Carolina, Ctr Gastrointestinal Biol & Dis, Chapel Hill, NC 27515 USA.4 aut
700	1	a Pearlman, Rachelu Ohio State Univ, Dept Internal Med, Div Human Genet, Ctr Comprehens Canc, Columbus, OH 43210 USA.4 aut
700	1	a Bishop, D. Timothyu Univ Leeds, Leeds Inst Canc & Pathol, Leeds, W Yorkshire, England.4 aut
700	1	a Castellvi-Bel, Sergiu Univ Barcelona, CIBEREHD, IDIBAPS, Dept Gastroenterol,Hosp Clin, Barcelona, Spain.4 aut
700	1	a Moreira, Leticiau Univ Barcelona, CIBEREHD, IDIBAPS, Dept Gastroenterol,Hosp Clin, Barcelona, Spain.4 aut
700	1	a Vodicka, Pavelu Czech Acad Sci, Inst Expt Med, Dept Mol Biol Canc, Prague, Czech Republic.;Charles Univ Prague, Fac Med 1, Inst Biol & Med Genet, Prague, Czech Republic.;Charles Univ Prague, Fac Med, Plzen, Czech Republic.;Charles Univ Prague, Biomed Ctr Pilsen, Plzen, Czech Republic.4 aut
700	1	a Kampman, Ellenu Wageningen Univ & Res, Div Human Nutr & Hlth, Wageningen, Netherlands.4 aut
700	1	a Giles, Graham G.u Univ Melbourne, Melbourne Sch Populat & Global Hlth, Ctr Biostat & Epidemiol, Melbourne, Vic, Australia.;H Lee Moffitt Canc Ctr & Res Inst, Dept Canc Epidemiol, Tampa, FL USA.4 aut
700	1	a Albanes, Demetriusu Univ Washington, Sch Publ Hlth, Dept Epidemiol, Seattle, WA 98195 USA.4 aut
700	1	a Baron, John A.u Univ N Carolina, Dept Med, Sch Med, Chapel Hill, NC 27515 USA.4 aut
700	1	a Berndt, Sonja I.u Univ Washington, Sch Publ Hlth, Dept Epidemiol, Seattle, WA 98195 USA.4 aut
700	1	a Brezina, Stefanieu Med Univ Vienna, Dept Med 1, Inst Canc Res, Vienna, Austria.4 aut
700	1	a Buch, Stephanu Univ Utah, Huntsman Canc Inst, Salt Lake City, UT USA.;Univ Utah, Dept Populat Hlth Sci, Salt Lake City, UT USA.4 aut
700	1	a Buchanan, Daniel D.u Univ Melbourne, Melbourne Sch Populat & Global Hlth, Ctr Biostat & Epidemiol, Melbourne, Vic, Australia.;Univ Melbourne, Dept Clin Pathol, Colorectal Oncogenom Grp, Parkville, Vic, Australia.;Royal Melbourne Hosp, Genom Med & Family Canc Clin, Parkville, Vic, Australia.;Univ Melbourne, Ctr Canc Res, Victorian Comprehens Canc Ctr, Parkville, Vic, Australia.4 aut
700	1	a Trichopoulou, Antoniau Hellen Hlth Fdn, Athens, Greece.4 aut
700	1	a Severi, Gianluca4 aut
700	1	a Chirlaque, Maria-Doloresu CIBERESP, Madrid, Spain.4 aut
700	1	a Sanchez, Maria-Jose4 aut
700	1	a Palli, Domenico4 aut
700	1	a Kuhn, Tilmanu German Canc Res Ctr, Div Canc Epidemiol, Heidelberg, Germany.4 aut
700	1	a Murphy, Neil4 aut
700	1	a Cross, Amanda J.4 aut
700	1	a Burnett-Hartman, Andrea N.4 aut
700	1	a Chanock, Stephen J.u Univ Washington, Sch Publ Hlth, Dept Epidemiol, Seattle, WA 98195 USA.4 aut
700	1	a de la Chapelle, Albert4 aut
700	1	a Easton, Douglas F.u Weill Cornell Med Coll, Dept Med, New York, NY USA.4 aut
700	1	a Elliott, Fayeu Univ Leeds, Leeds Inst Canc & Pathol, Leeds, W Yorkshire, England.4 aut
700	1	a English, Dallas R.u Univ Melbourne, Melbourne Sch Populat & Global Hlth, Ctr Biostat & Epidemiol, Melbourne, Vic, Australia.;Univ Virginia, Dept Family Med, Charlottesville, VA USA.4 aut
700	1	a Feskens, Edith J. M.u Wageningen Univ & Res, Div Human Nutr & Hlth, Wageningen, Netherlands.4 aut
700	1	a FitzGerald, Liesel M.u Canc Council Victoria, Canc Epidemiol & Intelligence Div, Melbourne, Vic, Australia.4 aut
700	1	a Goodman, Phyllis J.4 aut
700	1	a Hopper, John L.u Univ Melbourne, Melbourne Sch Populat & Global Hlth, Ctr Biostat & Epidemiol, Melbourne, Vic, Australia.4 aut
700	1	a Hudson, Thomas J.4 aut
700	1	a Hunter, David J.u Harvard Univ, Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA.4 aut
700	1	a Jacobs, Eric J.u Amer Canc Soc, Behav & Epidemiol Res Grp, Atlanta, GA USA.4 aut
700	1	a Joshu, Corinne E.4 aut
700	1	a Kury, Sebastienu Canc Council Victoria, Canc Epidemiol & Intelligence Div, Melbourne, Vic, Australia.4 aut
700	1	a Markowitz, Sanford D.u Karolinska Inst, Inst Environm Med, Stockholm, Sweden.4 aut
700	1	a Milne, Roger L.u Univ Melbourne, Melbourne Sch Populat & Global Hlth, Ctr Biostat & Epidemiol, Melbourne, Vic, Australia.;Canc Council Victoria, Canc Epidemiol & Intelligence Div, Melbourne, Vic, Australia.4 aut
700	1	a Platz, Elizabeth A.4 aut
700	1	a Rennert, Gad4 aut
700	1	a Rennert, Hedy S.4 aut
700	1	a Schumacher, Fredrick R.4 aut
700	1	a Sandler, Robert S.u Univ N Carolina, Ctr Gastrointestinal Biol & Dis, Chapel Hill, NC 27515 USA.4 aut
700	1	a Seminara, Daniela4 aut
700	1	a Tangen, Catherine M.4 aut
700	1	a Thibodeau, Stephen N.4 aut
700	1	a Toland, Amanda E.4 aut
700	1	a van Duijnhoven, Franzel J. B.u Wageningen Univ & Res, Div Human Nutr & Hlth, Wageningen, Netherlands.4 aut
700	1	a Visvanathan, Kala4 aut
700	1	a Vodickova, Ludmilau Czech Acad Sci, Inst Expt Med, Dept Mol Biol Canc, Prague, Czech Republic.;Charles Univ Prague, Fac Med 1, Inst Biol & Med Genet, Prague, Czech Republic.;Charles Univ Prague, Fac Med, Plzen, Czech Republic.;Charles Univ Prague, Biomed Ctr Pilsen, Plzen, Czech Republic.4 aut
700	1	a Potter, John D.u Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, 1124 Columbia St, Seattle, WA 98104 USA.4 aut
700	1	a Mannisto, Satu4 aut
700	1	a Weigl, Korbinianu German Canc Res Ctr, Div Clin Epidemiol & Aging Res, Heidelberg, Germany.4 aut
700	1	a Figueiredo, Janeu Univ Southern Calif, USC Norris Comprehens Canc Ctr, Keck Sch Med, Dept Prevent Med, Los Angeles, CA 90007 USA.4 aut
700	1	a Martin, Vicenteu CIBERESP, Madrid, Spain.4 aut
700	1	a Larsson, Susanna Cu Karolinska Inst, Dept Mol Med & Surg, Stockholm, Sweden.4 aut0 (Swepub:uu)susla720
700	1	a Parfrey, Patrick S.4 aut
700	1	a Huang, Wen-Yiu NCI, Div Canc Epidemiol & Genet, NIH, Bethesda, MD 20892 USA.4 aut
700	1	a Lenz, Heinz-Josef4 aut
700	1	a Castelao, Jose E.4 aut
700	1	a Gago-Dominguez, Manuela4 aut
700	1	a Munoz-Garzon, Victor4 aut
700	1	a Mancao, Christoph4 aut
700	1	a Haiman, Christopher A.u Univ Southern Calif, USC Norris Comprehens Canc Ctr, Keck Sch Med, Dept Prevent Med, Los Angeles, CA 90007 USA.4 aut
700	1	a Wilkens, Lynne R.4 aut
700	1	a Siegel, Erinu H Lee Moffitt Canc Ctr & Res Inst, Dept Canc Epidemiol, Tampa, FL USA.4 aut
700	1	a Barry, Elizabeth4 aut
700	1	a Younghusband, Banu Mem Univ Newfoundland, Discipline Genet, St John, NF, Canada.4 aut
700	1	a van Guelpen, Bethanyu Umeå universitet,Onkologi,Wallenberg centrum för molekylär medicin vid Umeå universitet (WCMM)4 aut0 (Swepub:umu)beyvan99
700	1	a Harlid, Sophia,d 1978-u Umeå universitet,Onkologi4 aut0 (Swepub:umu)soha0105
700	1	a Zeleniuch-Jacquotte, Anneu NYU, Div Epidemiol, Dept Populat Hlth, Sch Med, New York, NY USA.4 aut
700	1	a Liang, Peter S.4 aut
700	1	a Du, Mengmengu Mem Sloan Kettering Canc Ctr, Dept Epidemiol & Biostat, New York, NY 10021 USA.4 aut
700	1	a Casey, Graham4 aut
700	1	a Lindor, Noralane M.4 aut
700	1	a Le Marchand, Loic4 aut
700	1	a Gallinger, Steven J.4 aut
700	1	a Jenkins, Mark A.u Univ Melbourne, Melbourne Sch Populat & Global Hlth, Ctr Biostat & Epidemiol, Melbourne, Vic, Australia.4 aut
700	1	a Newcomb, Polly A.u Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, 1124 Columbia St, Seattle, WA 98104 USA.4 aut
700	1	a Gruber, Stephen B.4 aut
700	1	a Schoen, Robert E.4 aut
700	1	a Hampel, Heatheru Ohio State Univ, Dept Internal Med, Div Human Genet, Ctr Comprehens Canc, Columbus, OH 43210 USA.4 aut
700	1	a Corley, Douglas A.u Kaiser Permanente Northern Calif, Div Res, Oakland, CA USA.4 aut
700	1	a Hsu, Liu Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, 1124 Columbia St, Seattle, WA 98104 USA.4 aut
700	1	a Peters, Ulrikeu Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, 1124 Columbia St, Seattle, WA 98104 USA.;Mem Univ Newfoundland, Discipline Genet, St John, NF, Canada.4 aut
700	1	a Hayes, Richard B.u NYU, Div Epidemiol, Dept Populat Hlth, Sch Med, New York, NY USA.4 aut
710	2	a NYU, Div Epidemiol, Dept Populat Hlth, Sch Med, New York, NY USA.b Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, 1124 Columbia St, Seattle, WA 98104 USA.4 org
773	0	t Gastroenterologyd : Elsevier BVg 158:5, s. 1274-1286.e12q 158:5<1274-1286.e12x 0016-5085x 1528-0012
856	4	u https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7103489
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-419394
856	4 8	u https://doi.org/10.1053/j.gastro.2019.12.012
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-193623
856	4 8	u http://kipublications.ki.se/Default.aspx?queryparsed=id:143324808

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Av författaren/redakt...: Archambault, Ale ...; Su, Yu-Ru; Jeon, Jihyoun; Thomas, Minta; Lin, Yi; Conti, David V.; visa fler...; Win, Aung Ko; Sakoda, Lori C.; Lansdorp-Vogelaa ...; Peterse, Elisabe ...; Zauber, Ann G.; Duggan, David; Holowatyj, Andre ...; Huyghe, Jeroen R ...; Brenner, Hermann; Cotterchio, Mich ...; Bezieau, Stephan ...; Schmit, Stephani ...; Edlund, Christop ...; Southey, Melissa ...; MacInnis, Robert ...; Campbell, Peter ...; Chang-Claude, Je ...; Slattery, Martha ...; Chan, Andrew T.; Joshi, Amit D.; Song, Mingyang; Cao, Yin; Woods, Michael O ...; White, Emily; Weinstein, Steph ...; Ulrich, Cornelia ...; Hoffmeister, Mic ...; Bien, Stephanie ...; Harrison, Tabith ...; Hampe, Jochen; Li, Christopher ...; Schafmayer, Clem ...; Offit, Kenneth; Pharoah, Paul D.; Moreno, Victor; Lindblom, Annika; Wolk, Alicja; Wu, Anna H.; Li, Li; Gunter, Marc J.; Gsur, Andrea; Keku, Temitope O ...; Pearlman, Rachel; Bishop, D. Timot ...; Castellvi-Bel, S ...; Moreira, Leticia; Vodicka, Pavel; Kampman, Ellen; Giles, Graham G.; Albanes, Demetri ...; Baron, John A.; Berndt, Sonja I.; Brezina, Stefani ...; Buch, Stephan; Buchanan, Daniel ...; Trichopoulou, An ...; Severi, Gianluca; Chirlaque, Maria ...; Sanchez, Maria-J ...; Palli, Domenico; Kuhn, Tilman; Murphy, Neil; Cross, Amanda J.; Burnett-Hartman, ...; Chanock, Stephen ...; de la Chapelle, ...; Easton, Douglas ...; Elliott, Faye; English, Dallas ...; Feskens, Edith J ...; FitzGerald, Lies ...; Goodman, Phyllis ...; Hopper, John L.; Hudson, Thomas J ...; Hunter, David J.; Jacobs, Eric J.; Joshu, Corinne E ...; Kury, Sebastien; Markowitz, Sanfo ...; Milne, Roger L.; Platz, Elizabeth ...; Rennert, Gad; Rennert, Hedy S.; Schumacher, Fred ...; Sandler, Robert ...; Seminara, Daniel ...; Tangen, Catherin ...; Thibodeau, Steph ...; Toland, Amanda E ...; van Duijnhoven, ...; Visvanathan, Kal ...; Vodickova, Ludmi ...; Potter, John D.; Mannisto, Satu; Weigl, Korbinian; Figueiredo, Jane; Martin, Vicente; Larsson, Susanna ...; Parfrey, Patrick ...; Huang, Wen-Yi; Lenz, Heinz-Jose ...; Castelao, Jose E ...; Gago-Dominguez, ...; Munoz-Garzon, Vi ...; Mancao, Christop ...; Haiman, Christop ...; Wilkens, Lynne R ...; Siegel, Erin; Barry, Elizabeth; Younghusband, Ba ...; van Guelpen, Bet ...; Harlid, Sophia, ...; Zeleniuch-Jacquo ...; Liang, Peter S.; Du, Mengmeng; Casey, Graham; Lindor, Noralane ...; Le Marchand, Loi ...; Gallinger, Steve ...; Jenkins, Mark A.; Newcomb, Polly A ...; Gruber, Stephen ...; Schoen, Robert E ...; Hampel, Heather; Corley, Douglas ...; Hsu, Li; Peters, Ulrike; Hayes, Richard B ...; visa färre...

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