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Sökning: WFRF:(Koumarianou A.) > Virchow's node meta...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00004058naa a2200349 4500
001oai:DiVA.org:oru-98602
003SwePub
008220419s2022 | |||||||||||000 ||eng|
024a https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-986022 URI
040 a (SwePub)oru
041 a engb eng
042 9 SwePub
072 7a vet2 swepub-contenttype
072 7a art2 swepub-publicationtype
100a Wedin, M.,d 1977-u Örebro universitet,Institutionen för medicinska vetenskaper,Department of Surgery4 aut0 (Swepub:oru)mrwn
2451 0a Virchow's node metastasis from small intestinal neuroendocrine neoplasms :b A bi-center cohort study
264 1b John Wiley & Sons,c 2022
338 a print2 rdacarrier
520 a Introduction: Small Intestinal Neuroendocrine Neoplasms (SI-NENs) may rarely metastasize to the left supraclavicular lymph nodes, also known as Virchow’s node metastasis (VM).Aim(s): Data on prevalence, prognostic significance and clinical course of disease for SI-NEN patients with VM is limited.Materials and methods: In this retrospective analysis of 231 SI-NEN patients treated at two tertiary referal centers we found nine patients with VM. We used a control group of 18 age-and sex-matched SI-NEN patients from the same cohort with stage IV disease, but no extrahepatic metastases.Results: VM prevalence was 3.9% (9/231; 5 females, median age at VM diagnosis 65 years). Two patients had G1, 5 G2 tumours and 2 of unspecified grade. Four patients presented with synchronous VM, whereas 3 developed metachronous VM after a median of 24 months (range: 4.8–117.6 months). Hepatic metastases were present in 7 patients, extrahepatic metastases (EM) in 8 (6 para-aortic distant lymph node metastases, 1 lung and 1 pancreatic metastasis) and peritoneal carcinomatosis in 2 patients. There was no difference in best-recorded responses to 1st line treatment according to RECIST 1.1 as well as progression-free (PFS) and overall survival rates (PFS) between patients with VM and those in the control group (Chi-square p=0.516; PFS: 71.7 vs. 106.9 months [95%CI 38.1-175.8]; log-rank p=0.855; OS: 138.6 [95%CI 17.2–260] vs. 109.9 [95%CI 91.7–128] months; log-rank p=0.533).Conclusion: VM is relatively rare in patients with SI-NENs. It is more often encountered in patients withG2 tumors and EM, mainly to distant para-aortic lymph nodes. Its presence does not seem to impact patients’ survival outcomes and treatment responses, when compared to age-and sex-matched patients with stage IV disease. 
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng
653 a virchow's node metastasis
653 a small intestinal nen
700a Tsoli, M.u 1st Department of Propaedeutic and Internal Medicine, Laiko University Hospital, National and Kapodistrian University of Athens, Athens, Greece4 aut
700a Wallin, G.,d 1952-u Örebro universitet,Institutionen för medicinska vetenskaper,Department of Surgery4 aut0 (Swepub:oru)gwn
700a Janson, E. T.u Department of Medical Sciences, Uppsala University, Uppsala, Sweden4 aut
700a Koumarianou, A.u Hematology-Oncology Unit, Fourth Department of Internal Medicine, Attikon Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece4 aut
700a Kaltsas, G.u 1st Department of Propaupedic Internal Medicine, Endocrine Oncology Unit, Laiko Hospital, Athens, Greece4 aut
700a Daskalakis, K.,d 1979-u Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Department of Surgery4 aut0 (Swepub:oru)kds
710a Örebro universitetb Institutionen för medicinska vetenskaper4 org
773t Journal of neuroendocrinology (Print)d : John Wiley & Sonsg 34:Suppl. 1, s. 88-88q 34:Suppl. 1<88-88x 0953-8194x 1365-2826
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-98602

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