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Sökning: WFRF:(Calero I) > Carpal Tunnel Syndr...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00004148naa a2200601 4500
001oai:gup.ub.gu.se/327826
003SwePub
008240528s2023 | |||||||||||000 ||eng|
024a https://gup.ub.gu.se/publication/3278262 URI
024a https://doi.org/10.3390/biomedicines110617442 DOI
040 a (SwePub)gu
041 a eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
100a Fernandez-de-las-Penas, C.4 aut
2451 0a Carpal Tunnel Syndrome: Neuropathic Pain Associated or Not with a Nociplastic Condition
264 1c 2023
520 a Carpal tunnel syndrome (CTS) has been traditionally classified as primarily a neuropathic condition with or without pain. Precision medicine refers to an evidence-based method of grouping patients based on their susceptibility to biology, prognosis of a particular disease, or in their response to a specific treatment, and tailoring specific treatments accordingly. In 2021, the International Association for the Study of Pain (IASP) proposed a grading system for classifying patients into nociceptive, neuropathic, or nociplastic phenotypes. This position paper presents data supporting the possibility of subgrouping individuals with specific CTS related-pain into nociceptive, neuropathic, nociplastic or mixed-type phenotypes. Carpal tunnel syndrome is a neuropathic condition but can also be comorbid with a nociplastic pain condition. The presence of extra-median symptoms and the development of facilitated pain processing seem to be signs suggesting that specific CTS cases can be classified as the nociplastic pain phenotype. The clinical responses of therapeutic approaches for the management of CTS are inconclusive. Accordingly, the ability to identify the predominant pain phenotype in patients with CTS could likely be problematic for producing efficient treatment outcomes. In fact, the presence of a nociplastic or mixed-type pain phenotype would explain the lack of clinical effect of treatment interventions targeting the carpal tunnel area selectively. We propose a clinical decision tree by using the 2021 IASP classification criteria for identifying the predominant pain phenotype in people with CTS-related pain, albeit CTS being a priori a neuropathic pain condition. The identification of a nociplastic-associated condition requires a more nuanced multimodal treatment approach to achieve better treatment outcomes.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Farmakologi och toxikologi0 (SwePub)301022 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Pharmacology and Toxicology0 (SwePub)301022 hsv//eng
653 a carpal tunnel syndrome
653 a median nerve
653 a nociceptive
653 a neuropathic
653 a nociplastic pain
653 a precision medicine
653 a peripheral drive
653 a central
653 a sensitization
653 a sensitivity
653 a symptoms
653 a neuroplasticity
653 a definition
653 a prevalence
653 a deficits
653 a therapy
653 a surgery
653 a system
653 a Biochemistry & Molecular Biology
653 a Research & Experimental Medicine
653 a Pharmacology & Pharmacy
700a Fuensalida-Novo, S.4 aut
700a Nijs, Jou Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för hälsa och rehabilitering,Institute of Neuroscience and Physiology, Department of Health and Rehabilitation4 aut
700a Basson, A.4 aut
700a Plaza-Manzano, G.4 aut
700a Valera-Calero, J. A.4 aut
700a Arendt-Nielsen, L.4 aut
700a de-la-Llave-Rincon, A. I.4 aut
710a Göteborgs universitetb Institutionen för neurovetenskap och fysiologi, sektionen för hälsa och rehabilitering4 org
773t Biomedicinesg 11:6q 11:6x 2227-9059
8564 8u https://gup.ub.gu.se/publication/327826
8564 8u https://doi.org/10.3390/biomedicines11061744

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