Elevated levels of the human endogenous retrovirus ERV3 in human sebaceous glands

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Fältnamn	Indikatorer	Metadata
000		02819naa a2200337 4500
001		oai:DiVA.org:uu-89897
003		SwePub
008		020510s1996 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-898972 URI
024	7	a https://doi.org/10.1111/1523-1747.ep123296122 DOI
040		a (SwePub)uu
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Andersson, Ann-Catrinu Uppsala universitet,Institutionen för patologi4 aut
245	1 0	a Elevated levels of the human endogenous retrovirus ERV3 in human sebaceous glands
264	1	b Elsevier BV,c 1996
338		a print2 rdacarrier
520		a ERV3 (HERV-R) is a complete human endogenous retrovirus located on the long arm of chromosome 7. Long terminal repeat-envelope (env) gene spliced mRNAs of 9 and 3.5 kb are widely expressed in human tissues and cells, but gag-pol mRNAs have not been found. Furthermore, the env gp70 gene contains an open reading frame throughout its length. The highest expression of ERV3 mRNA detected so far is in placenta and the lowest in choriocarcinoma cell lines. We have previously shown that the human monoblastic cell line U-937 and some normal and neoplastic tissues also express high levels of ERV3 env message by Northern blot analysis; however, this method does not distinguish between mRNA expression in different cell types in tissues. In this report, we have studied the ERV3 mRNA expression in specific cell types of human skin by in situ hybridization. We found high levels expression of ERV3 env mRNA in human sebaceous glands in normal skin and dermoid cysts of the ovary. In all glands, the expression is maximal in the periphery of the lobule and ceases towards the center in the region of characteristic holocrine secretion. Since it is known that the regulation of sebaceous glands is primarily via steroid hormones, particularly androgens, it is possible that expression of ERV3 is hormone dependent.
700	1	a Merza, Malik4 aut
700	1	a Venables, Patrick JW4 aut
700	1	a Pontén, Fredriku Uppsala universitet,Institutionen för patologi4 aut0 (Swepub:uu)fredpont
700	1	a Sundström, Johanu Uppsala universitet,Institutionen för patologi4 aut
700	1	a Cohen, Maurice4 aut
700	1	a Larsson, Eriku Uppsala universitet,Institutionen för patologi4 aut0 (Swepub:uu)eriklars
710	2	a Uppsala universitetb Institutionen för patologi4 org
773	0	t Journal of Investigative Dermatologyd : Elsevier BVg 106:1, s. 125-128q 106:1<125-128x 0022-202Xx 1523-1747
856	4	u https://doi.org/10.1111/1523-1747.ep12329612
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-89897
856	4 8	u https://doi.org/10.1111/1523-1747.ep12329612

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Av författaren/redakt...: Andersson, Ann-C ...; Merza, Malik; Venables, Patric ...; Pontén, Fredrik; Sundström, Johan; Cohen, Maurice; visa fler...; Larsson, Erik; visa färre...

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