No association between immunohistochemical expression of p53, c-erbB-2, Ki-67, estrogen and progesterone receptors in female papillary thyroid cancer and ionizing radiation

Karlsson, Mats G.,1960-Department of Pathology, Örebro Medical Center, Örebro, Sweden (författare)

An association has previously been reported between exposure to medical diagnostic ionizing radiation and papillary thyroid cancer in women. To further evaluate potential mechanisms in carcinogenesis, the expression of p53, c-erbB-2, as well as Ki-67, estrogen and progesterone receptors were analyzed by immunohistochemistry in 19 women exposed to X-rays and for comparison in nine women without such reported exposure. They all had papillary thyroid cancer. No difference was found between these groups. The results of this study showed that p53, c-erbB-2, Ki-67, estrogen and progesterone receptors are not involved in papillary thyroid cancer associated with exposure to medical diagnostic ionizing radiation.

Hardell, Lennart,1944-Department of Oncology, Örebro Medical Center, Örebro, Sweden (författare)
Hallquist, ArneStockholms Sjukhem, Stockholm, Sweden (författare)
Department of Pathology, Örebro Medical Center, Örebro, SwedenDepartment of Oncology, Örebro Medical Center, Örebro, Sweden (creator_code:org_t)

Ingår i:Cancer LettersClare, Ireland : Elsevier120:2, s. 173-1770304-38351872-7980

Av författaren/redakt...: Karlsson, Mats G ...; Hardell, Lennart ...; Hallquist, Arne

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