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Sökning: WFRF:(Bolton Judith A. Hoffman) > Circulating Folate,...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00005644naa a2200985 4500
001oai:DiVA.org:umu-142388
003SwePub
008171129s2018 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1423882 URI
0247 a https://doi.org/10.1093/jnci/djx1192 DOI
040 a (SwePub)umu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Fanidi, Anouar4 aut
2451 0a Circulating Folate, Vitamin B6, and Methionine in Relation to Lung Cancer Risk in the Lung Cancer Cohort Consortium (LC3)
264 c 2017-07-22
264 1b Oxford University Press,c 2018
338 a print2 rdacarrier
520 a Background: Circulating concentrations of B vitamins and factors related to one-carbon metabolism have been found to be strongly inversely associated with lung cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. The extent to which these associations are present in other study populations is unknown.Methods: Within 20 prospective cohorts from the National Cancer Institute Cohort Consortium, a nested case-control study was designed including 5364 incident lung cancer case patients and 5364 control subjects who were individually matched to case patients by age, sex, cohort, and smoking status. Centralized biochemical analyses were performed to measure circulating concentrations of vitamin B6, folate, and methionine, as well as cotinine as an indicator of recent tobacco exposure. The association between these biomarkers and lung cancer risk was evaluated using conditional logistic regression models.Results: Participants with higher circulating concentrations of vitamin B6 and folate had a modestly decreased risk of lung cancer risk overall, the odds ratios when comparing the top and bottom fourths (OR 4vs1 ) being 0.88 (95% confidence interval [CI] = 0.78 to 1.00) and 0.86 (95% CI = 0.74 to 0.99), respectively. We found stronger associations among men (vitamin B6: OR 4vs1 = 0.74, 95% CI = 0.62 to 0.89; folate: OR 4vs1 = 0.75, 95% CI = 0.61 to 0.93) and ever smokers (vitamin B6: OR 4vs1 = 0.78, 95% CI = 0.67 to 0.91; folate: OR 4vs1 = 0.87, 95% CI = 0.73 to 1.03). We further noted that the association of folate was restricted to Europe/Australia and Asia, whereas no clear association was observed for the United States. Circulating concentrations of methionine were not associated with lung cancer risk overall or in important subgroups.Conclusions: Although confounding by tobacco exposure or reverse causation cannot be ruled out, these study results are compatible with a small decrease in lung cancer risk in ever smokers who avoid low concentrations of circulating folate and vitamin B6.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
7001 a Muller, David C4 aut
7001 a Yuan, Jian-Min4 aut
7001 a Stevens, Victoria L4 aut
7001 a Weinstein, Stephanie J4 aut
7001 a Albanes, Demetrius4 aut
7001 a Prentice, Ross4 aut
7001 a Thomsen, Cynthia A4 aut
7001 a Pettinger, Mary4 aut
7001 a Cai, Qiuyin4 aut
7001 a Blot, William J4 aut
7001 a Wu, Jie4 aut
7001 a Arslan, Alan A4 aut
7001 a Zeleniuch-Jacquotte, Anne4 aut
7001 a McCullough, Marjorie L4 aut
7001 a Le Marchand, Loic4 aut
7001 a Wilkens, Lynne R4 aut
7001 a Haiman, Christopher A4 aut
7001 a Zhang, Xuehong4 aut
7001 a Han, Jiali4 aut
7001 a Stampfer, Meir J4 aut
7001 a Smith-Warner, Stephanie A4 aut
7001 a Giovannucci, Edward4 aut
7001 a Giles, Graham G4 aut
7001 a Hodge, Allison M4 aut
7001 a Severi, Gianluca4 aut
7001 a Johansson, Mikaelu Umeå universitet,Onkologi4 aut0 (Swepub:umu)mijo0025
7001 a Grankvist, Kjellu Umeå universitet,Klinisk kemi4 aut0 (Swepub:umu)kjgr0002
7001 a Langhammer, Arnulf4 aut
7001 a Krokstad, Steinar4 aut
7001 a Næss, Marit4 aut
7001 a Wang, Renwei4 aut
7001 a Gao, Yu-Tang4 aut
7001 a Butler, Lesley M4 aut
7001 a Koh, Woon-Puay4 aut
7001 a Shu, Xiao-Ou4 aut
7001 a Xiang, Yong-Bing4 aut
7001 a Li, Honglan4 aut
7001 a Zheng, Wei4 aut
7001 a Lan, Qing4 aut
7001 a Visvanathan, Kala4 aut
7001 a Bolton, Judith Hoffman4 aut
7001 a Ueland, Per Magne4 aut
7001 a Midttun, Øivind4 aut
7001 a Ulvik, Arve4 aut
7001 a Caporaso, Neil E4 aut
7001 a Purdue, Mark4 aut
7001 a Ziegler, Regina G4 aut
7001 a Freedman, Neal D4 aut
7001 a Buring, Julie E4 aut
7001 a Lee, I-Min4 aut
7001 a Sesso, Howard D4 aut
7001 a Gaziano, J Michael4 aut
7001 a Manjer, Jonas4 aut
7001 a Ericson, Ulrika4 aut
7001 a Relton, Caroline4 aut
7001 a Brennan, Paul4 aut
7001 a Johansson, Mattias4 aut
7102 a Umeå universitetb Onkologi4 org
7730 t Journal of the National Cancer Instituted : Oxford University Pressg 110:1q 110:1x 0027-8874x 1460-2105
8564 u https://academic.oup.com/jnci/article-pdf/110/1/57/25422471/djx119.pdf
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-142388
8564 8u https://doi.org/10.1093/jnci/djx119

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