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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
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| 008 | 240701s2020 | |||||||||||000 ||eng| | |
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| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1443249882 URI |
| 024 | 7 | a https://doi.org/10.1038/s41598-020-68848-92 DOI |
| 024 | 7 | a https://lup.lub.lu.se/record/292de28e-8974-48d7-a4f1-6e3913ecad002 URI |
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| 041 | a engb eng | |
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| 100 | 1 | a Gao, YXu Xuzhou Medical University4 aut |
| 245 | 1 0 | a Mendelian randomization implies no direct causal association between leukocyte telomere length and amyotrophic lateral sclerosis |
| 264 | c 2020-07-22 | |
| 264 | 1 | b Springer Science and Business Media LLC,c 2020 |
| 520 | a We employed Mendelian randomization (MR) to evaluate the causal relationship between leukocyte telomere length (LTL) and amyotrophic lateral sclerosis (ALS) with summary statistics from genome-wide association studies (n = ~ 38,000 for LTL and ~ 81,000 for ALS in the European population; n = ~ 23,000 for LTL and ~ 4,100 for ALS in the Asian population). We further evaluated mediation roles of lipids in the pathway from LTL to ALS. The odds ratio per standard deviation decrease of LTL on ALS was 1.10 (95% CI 0.93–1.31, p = 0.274) in the European population and 0.75 (95% CI 0.53–1.07, p = 0.116) in the Asian population. This null association was also detected between LTL and frontotemporal dementia in the European population. However, we found that an indirect effect of LTL on ALS might be mediated by low density lipoprotein (LDL) or total cholesterol (TC) in the European population. These results were robust against extensive sensitivity analyses. Overall, our MR study did not support the direct causal association between LTL and the ALS risk in neither population, but provided suggestive evidence for the mediation role of LDL or TC on the influence of LTL and ALS in the European population. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Medicinsk genetik0 (SwePub)301072 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Medical Genetics0 (SwePub)301072 hsv//eng |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Neurovetenskaper0 (SwePub)301052 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Neurosciences0 (SwePub)301052 hsv//eng |
| 700 | 1 | a LANDQVIST WALDÖ, MARIAu Lund University,Lunds universitet,Kliniska Vetenskaper, Helsingborg,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Psykiatri, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Clinical Sciences, Helsingborg,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Psychiatry (Lund),Section IV,Department of Clinical Sciences, Lund4 aut0 (Swepub:lu)med-mlv |
| 700 | 1 | a Yu, XH4 aut |
| 700 | 1 | a Zhao, HS4 aut |
| 700 | 1 | a Zeng, Pu Xuzhou Medical University4 aut |
| 700 | 1 | a Ferrari, R4 aut |
| 700 | 1 | a Hernandez, DG4 aut |
| 700 | 1 | a Nails, MA4 aut |
| 700 | 1 | a Rohrers, JD4 aut |
| 700 | 1 | a Ramasamys, A4 aut |
| 700 | 1 | a Kwok, JBJ4 aut |
| 700 | 1 | a Dobson-Stone, C4 aut |
| 700 | 1 | a Brooks, WS4 aut |
| 700 | 1 | a Schofield, PR4 aut |
| 700 | 1 | a Halliday, GM4 aut |
| 700 | 1 | a Hodges, JR4 aut |
| 700 | 1 | a Piguet, O4 aut |
| 700 | 1 | a Bartley, L4 aut |
| 700 | 1 | a Thompson, E4 aut |
| 700 | 1 | a Haan, E4 aut |
| 700 | 1 | a Hernandez, I4 aut |
| 700 | 1 | a Ruiz, A4 aut |
| 700 | 1 | a Boada, M4 aut |
| 700 | 1 | a Borronils, B4 aut |
| 700 | 1 | a Padovani, A4 aut |
| 700 | 1 | a Cruchaga, C4 aut |
| 700 | 1 | a Cairns, NJ4 aut |
| 700 | 1 | a Benussi, L4 aut |
| 700 | 1 | a Binetti, G4 aut |
| 700 | 1 | a Ghidoni, R4 aut |
| 700 | 1 | a Forloni, G4 aut |
| 700 | 1 | a Albani, D4 aut |
| 700 | 1 | a Galimberti, D4 aut |
| 700 | 1 | a Fenoglio, C4 aut |
| 700 | 1 | a Serpente, M4 aut |
| 700 | 1 | a Scarpini, E4 aut |
| 700 | 1 | a Clarim, J4 aut |
| 700 | 1 | a Lie, A4 aut |
| 700 | 1 | a Blesa, R4 aut |
| 700 | 1 | a Waldo, ML4 aut |
| 700 | 1 | a Nilsson, Karinu Lund University,Lunds universitet,Psykiatri, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Psychiatry (Lund),Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)med-kan |
| 700 | 1 | a Nilsson, Christeru Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups4 aut0 (Swepub:lu)neur-cni |
| 700 | 1 | a Mackenzie, IRA4 aut |
| 700 | 1 | a Hsiung, GYR4 aut |
| 700 | 1 | a Mann, DMA4 aut |
| 700 | 1 | a Grafman, J4 aut |
| 700 | 1 | a Morris, CM4 aut |
| 700 | 1 | a Attems, J4 aut |
| 700 | 1 | a Griffiths, TD4 aut |
| 700 | 1 | a McKeith, IG4 aut |
| 700 | 1 | a Thomas, AJ4 aut |
| 700 | 1 | a Pietrini, P4 aut |
| 700 | 1 | a Huey, ED4 aut |
| 700 | 1 | a Wassermann, EM4 aut |
| 700 | 1 | a Baborie, A4 aut |
| 700 | 1 | a Jaros, E4 aut |
| 700 | 1 | a Tierney, MC4 aut |
| 700 | 1 | a Pastor, P4 aut |
| 700 | 1 | a Razquin, C4 aut |
| 700 | 1 | a Ortega-Cubero, S4 aut |
| 700 | 1 | a Alonso, E4 aut |
| 700 | 1 | a Perneczky, R4 aut |
| 700 | 1 | a Diehl-Schmid, J4 aut |
| 700 | 1 | a Alexopoulos, P4 aut |
| 700 | 1 | a Kurz, A4 aut |
| 700 | 1 | a Rainero, I4 aut |
| 700 | 1 | a Rubino, E4 aut |
| 700 | 1 | a Pinessi, L4 aut |
| 700 | 1 | a Rogaeva, E4 aut |
| 700 | 1 | a St George-Hyslop, P4 aut |
| 700 | 1 | a Rossi, G4 aut |
| 700 | 1 | a Tagliavini, F4 aut |
| 700 | 1 | a Giacconen, G4 aut |
| 700 | 1 | a Rowe, JB4 aut |
| 700 | 1 | a Schlachetzki, JCM4 aut |
| 700 | 1 | a Uphill, J4 aut |
| 700 | 1 | a Collinge, J4 aut |
| 700 | 1 | a Mead, S4 aut |
| 700 | 1 | a Danek, A4 aut |
| 700 | 1 | a Van Deerlin, VM4 aut |
| 700 | 1 | a Grossman, M4 aut |
| 700 | 1 | a Trojanowski, JQ4 aut |
| 700 | 1 | a van der Zee, J4 aut |
| 700 | 1 | a Cruts, M4 aut |
| 700 | 1 | a Van Broeckhoven, C4 aut |
| 700 | 1 | a Cappa, SF4 aut |
| 700 | 1 | a Leber, I4 aut |
| 700 | 1 | a Hannequin, D4 aut |
| 700 | 1 | a Golfier, V4 aut |
| 700 | 1 | a Vercelletto, M4 aut |
| 700 | 1 | a Brice, A4 aut |
| 700 | 1 | a Nacmias, B4 aut |
| 700 | 1 | a Sorbi, S4 aut |
| 700 | 1 | a Bagnoli, S4 aut |
| 700 | 1 | a Piaceri, I4 aut |
| 700 | 1 | a Nielsen, JE4 aut |
| 700 | 1 | a Hjermind, LE4 aut |
| 700 | 1 | a Riemenschneider, M4 aut |
| 700 | 1 | a Mayhaus, M4 aut |
| 700 | 1 | a Ibach, B4 aut |
| 700 | 1 | a Gasparoni, G4 aut |
| 700 | 1 | a Pichler, S4 aut |
| 700 | 1 | a Gu, W4 aut |
| 700 | 1 | a Rossor, MN4 aut |
| 700 | 1 | a Fox, NC4 aut |
| 700 | 1 | a Warren, JD4 aut |
| 700 | 1 | a Spillantini, MG4 aut |
| 700 | 1 | a Morris, HR4 aut |
| 700 | 1 | a Rizzu, P4 aut |
| 700 | 1 | a Heutink, P4 aut |
| 700 | 1 | a Snowden, JS4 aut |
| 700 | 1 | a Rollinson, S4 aut |
| 700 | 1 | a Richardson, A4 aut |
| 700 | 1 | a Gerhard, A4 aut |
| 700 | 1 | a Bruni, AC4 aut |
| 700 | 1 | a Maletta, R4 aut |
| 700 | 1 | a Frangipane, F4 aut |
| 700 | 1 | a Cupidi, C4 aut |
| 700 | 1 | a Bernardi, L4 aut |
| 700 | 1 | a Anfossi, M4 aut |
| 700 | 1 | a Gallo, M4 aut |
| 700 | 1 | a Conidi, ME4 aut |
| 700 | 1 | a Smirne, N4 aut |
| 700 | 1 | a Rademakers, R4 aut |
| 700 | 1 | a Baker, M4 aut |
| 700 | 1 | a Dickson, DW4 aut |
| 700 | 1 | a Graff-Radford, NR4 aut |
| 700 | 1 | a Petersen, RC4 aut |
| 700 | 1 | a Knopman, D4 aut |
| 700 | 1 | a Josephs, KA4 aut |
| 700 | 1 | a Boeve, BF4 aut |
| 700 | 1 | a Parisi, JE4 aut |
| 700 | 1 | a Seeley, WW4 aut |
| 700 | 1 | a Miller, BL4 aut |
| 700 | 1 | a Karydas, AM4 aut |
| 700 | 1 | a Rosen, H4 aut |
| 700 | 1 | a van Swieten, JC4 aut |
| 700 | 1 | a Dopper, EGP4 aut |
| 700 | 1 | a Seelaar, H4 aut |
| 700 | 1 | a Pijnenburg, YAL4 aut |
| 700 | 1 | a Scheltens, P4 aut |
| 700 | 1 | a Logroscino, G4 aut |
| 700 | 1 | a Capozzo, R4 aut |
| 700 | 1 | a Novelli, V4 aut |
| 700 | 1 | a Puca, AA4 aut |
| 700 | 1 | a Franceschi, M4 aut |
| 700 | 1 | a Postiglione, A4 aut |
| 700 | 1 | a Milan, G4 aut |
| 700 | 1 | a Sorrentino, P4 aut |
| 700 | 1 | a Kristiansen, M4 aut |
| 700 | 1 | a Huei-Hsin, G4 aut |
| 700 | 1 | a Graff, CC4 aut |
| 700 | 1 | a Pasquier, F4 aut |
| 700 | 1 | a Rollin, A4 aut |
| 700 | 1 | a Deramecourt, V4 aut |
| 700 | 1 | a Lebouvier, T4 aut |
| 700 | 1 | a Ferrucci, L4 aut |
| 700 | 1 | a Pickering-Brown, S4 aut |
| 700 | 1 | a Singleton, AB4 aut |
| 700 | 1 | a Hardy, J4 aut |
| 700 | 1 | a Momeni, P4 aut |
| 710 | 2 | a Xuzhou Medical Universityb Kliniska Vetenskaper, Helsingborg4 org |
| 773 | 0 | t Scientific reportsd : Springer Science and Business Media LLCg 10:1, s. 12184-q 10:1<12184-x 2045-2322 |
| 856 | 4 | u https://www.nature.com/articles/s41598-020-68848-9.pdf |
| 856 | 4 | u http://dx.doi.org/10.1038/s41598-020-68848-9x freey FULLTEXT |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:144324988 |
| 856 | 4 8 | u https://doi.org/10.1038/s41598-020-68848-9 |
| 856 | 4 8 | u https://lup.lub.lu.se/record/292de28e-8974-48d7-a4f1-6e3913ecad00 |
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