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A single dose of en...
A single dose of enterolactone activates estrogen signaling and regulates expression of circadian clock genes in mice.
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- Damdimopoulou, Pauliina (author)
- Karolinska Institutet
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Nurmi, Tarja (author)
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Salminen, Anu (author)
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- Damdimopoulos, Anastasios E (author)
- Karolinska Institutet
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Kotka, Maria (author)
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van der Saag, Paul (author)
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Strauss, Leena (author)
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- Poutanen, Matti (author)
- Gothenburg University,Göteborgs universitet,Centre for Bone and Arthritis Research
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- Pongratz, Ingemar (author)
- Karolinska Institutet
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Mäkelä, Sari (author)
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(creator_code:org_t)
- Elsevier BV, 2011
- 2011
- English.
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In: The Journal of nutrition. - : Elsevier BV. - 1541-6100 .- 0022-3166. ; 141:9, s. 1583-9
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Abstract
Subject headings
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- Enterolactone (EL) is an enterolignan produced by gut microbiota from dietary plant lignans. Epidemiological and experimental studies suggest that EL and plant lignans may reduce the risk of breast and prostate cancer as well as cardiovascular disease. These effects are thought to at least in part involve modulation of estrogen receptor activity. Surprisingly little is known about the in vivo estrogenicity of EL. In the present study, we investigated the target tissues of EL, the genes affected by EL treatment, and the response kinetics. Following a single dose of EL, luciferase was significantly induced in reproductive and nonreproductive tissues of male and female 3xERE-luciferase mice, indicating estrogen-like activity. Microarray analysis revealed that EL regulated the expression of only 1% of 17β-estradiol target genes in the uterus. The majority of these genes were traditional estrogen target genes, but also members of the circadian signaling pathway were affected. Kinetic analyses showed that EL undergoes rapid phase II metabolism and is efficiently excreted. In vivo imaging demonstrated that the estrogen response followed similar, fast kinetics. We conclude that EL activates estrogen signaling in both male and female mice and that the transient responses may be due to the fast metabolism of the compound. Lastly, EL may represent a link among diet, gut microbiota, and circadian signaling.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Keyword
- 4-Butyrolactone
- analogs & derivatives
- blood
- pharmacology
- Animals
- CLOCK Proteins
- genetics
- metabolism
- Circadian Clocks
- drug effects
- genetics
- Estradiol
- pharmacology
- Estrogens
- metabolism
- Female
- Gene Expression Regulation
- drug effects
- Lignans
- blood
- pharmacology
- Liver
- metabolism
- Luciferases
- metabolism
- Male
- Mice
- Mice
- Inbred C57BL
- Orchiectomy
- Ovariectomy
- Phytoestrogens
- pharmacology
- Protein Array Analysis
- Random Allocation
- Signal Transduction
- drug effects
- Uterus
- metabolism
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Damdimopoulou, P ...
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Nurmi, Tarja
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Salminen, Anu
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Damdimopoulos, A ...
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Kotka, Maria
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van der Saag, Pa ...
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show more...
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Strauss, Leena
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Poutanen, Matti
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Pongratz, Ingema ...
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Mäkelä, Sari
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Endocrinology an ...
- Articles in the publication
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The Journal of n ...
- By the university
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University of Gothenburg
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Karolinska Institutet