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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00008259naa a2200913 4500
001oai:DiVA.org:uu-423938
003SwePub
008201109s2020 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4239382 URI
0247 a https://doi.org/10.1016/j.jtho.2020.06.0012 DOI
040 a (SwePub)uu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Moreira, Andre L.u New York Univ Langone Hlth, Dept Pathol, 560 First Ave,TH 4-15B, New York, NY 10016 USA.4 aut
2451 0a A Grading System for Invasive Pulmonary Adenocarcinoma :b A Proposal From the International Association for the Study of Lung Cancer Pathology Committee
264 1b ELSEVIER SCIENCE INC,c 2020
338 a print2 rdacarrier
520 a Introduction: A grading system for pulmonary adenocarcinoma has not been established. The International Association for the Study of Lung Cancer pathology panel evaluated a set of histologic criteria associated with prognosis aimed at establishing a grading system for invasive pulmonary adenocarcinoma. Methods: A multi-institutional study involving multiple cohorts of invasive pulmonary adenocarcinomas was conducted. A cohort of 284 stage I pulmonary adenocarcinomas was used as a training set to identify histologic features associated with patient outcomes (recurrence-free survival [RFS] and overall survival [OS]). Receiver operating characteristic curve analysis was used to select the best model, which was validated (n = 212) and tested (n = 300, including stage I-III) in independent cohorts. Reproducibility of the model was assessed using kappa statistics. Results: The best model (area under the receiver operating characteristic curve [AUC] = 0.749 for RFS and 0.787 for OS) was composed of a combination of predominant plus high-grade histologic pattern with a cutoff of 20% for the latter. The model consists of the following: grade 1, lepidic predominant tumor; grade 2, acinar or papillary predominant tumor, both with no or less than 20% of high-grade patterns; and grade 3, any tumor with 20% or more of high-grade patterns (solid, micropapillary, or complex gland). Similar results were seen in the validation (AUC = 0.732 for RFS and 0.787 for OS) and test cohorts (AUC = 0.690 for RFS and 0.743 for OS), confirming the predictive value of the model. Interobserver reproducibility revealed good agreement (k = 0.617). Conclusions: A grading system based on the predominant and high-grade patterns is practical and prognostic for invasive pulmonary adenocarcinoma. (C) 2020 International Association for the Study of Lung Cancer. Published by Elsevier Inc. All rights reserved.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Klinisk laboratoriemedicin0 (SwePub)302232 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Clinical Laboratory Medicine0 (SwePub)302232 hsv//eng
653 a Adenocarcinoma
653 a Tumor grading
653 a Lung
653 a Model
653 a Prognosis
653 a Patologi
653 a Pathology
7001 a Ocampo, Paolo S. S.u New York Univ Langone Hlth, Dept Pathol, 560 First Ave,TH 4-15B, New York, NY 10016 USA.4 aut
7001 a Xia, Yuheu New York Univ Langone Hlth, Dept Biostat, New York, NY 10016 USA.4 aut
7001 a Zhong, Huau New York Univ Langone Hlth, Dept Biostat, New York, NY 10016 USA.4 aut
7001 a Russell, Prudence A.u St Vincents Hosp, Dept Pathol, Fitzroy, Vic, Australia.4 aut
7001 a Minami, Yukou Ibarakihigashi Natl Hosp, Dept Pathol, Tokai, Ibaraki, Japan.4 aut
7001 a Cooper, Wendy A.u Royal Prince Alfred Hosp, Dept Pathol, Camperdown, NSW, Australia.4 aut
7001 a Yoshida, Akihikou Natl Canc Ctr, Dept Diagnost Pathol, Tokyo, Japan.4 aut
7001 a Bubendorf, Lukasu Univ Basel, Univ Hosp Basel, Inst Med Genet & Pathol, Basel, Switzerland.4 aut
7001 a Papotti, Maurou Univ Turin, Dept Oncol, Turin, Italy.4 aut
7001 a Pelosi, Giuseppeu Univ Milan, Dept Pathol, Milan, Italy.;IRCCS MultiMed, Milan, Italy.4 aut
7001 a Lopez-Rios, Fernandou HM Hosp, Pathol Lab Dianas Terapeut, Madrid, Spain.4 aut
7001 a Kunitoki, Keikou Harvard TH Chan Sch Publ Hlth, Boston, MA USA.4 aut
7001 a Ferrari-Light, Danau New York Univ Langone Hlth, Dept Surg, New York, NY 10016 USA.4 aut
7001 a Sholl, Lynette M.u Harvard Med Sch, Brigham & Womens Hosp, Dept Pathol, Boston, MA 02115 USA.4 aut
7001 a Beasley, Mary Bethu Mt Sinai Hlth Syst, Icahn Sch Med, Dept Pathol, New York, NY USA.4 aut
7001 a Borczuk, Alainu Weill Cornell Med, Dept Pathol, New York, NY USA.4 aut
7001 a Botling, Johanu Uppsala universitet,Klinisk och experimentell patologi,Johan Botling4 aut0 (Swepub:uu)johanbot
7001 a Brambilla, Elisabethu Univ Grenoble Alpes, Dept Anat Pathol & Cytol, Grenoble, France.4 aut
7001 a Chen, Gangu Fudan Univ, Zhongshan Hosp, Dept Pathol, Shanghai, Peoples R China.4 aut
7001 a Chou, Teh-Yingu Taipei Vet Gen Hosp, Dept Pathol, Taipei, Taiwan.4 aut
7001 a Chung, Jin-Haengu Seoul Natl Univ, Dept Pathol, Bundang Hosp, Seoul, South Korea.4 aut
7001 a Dacic, Sanjau Univ Pittsburgh, Dept Pathol, Med Ctr, Pittsburgh, PA USA.4 aut
7001 a Jain, Deepaliu All India Inst Med Sci, Dept Pathol, New Delhi, India.4 aut
7001 a Hirsch, Fred R.u Tisch Canc Inst, Ctr Thorac Oncol, New York, NY USA.4 aut
7001 a Hwang, Davidu Sunnybrook Hlth Sci Ctr, Dept Lab Med & Mol Diagnost, Toronto, ON, Canada.4 aut
7001 a Lantuejoul, Sylvieu Ctr Leon Berard Unicanc, Dept Pathol, Lyon, France.4 aut
7001 a Lin, Dongmeiu Peking Univ, Dept Pathol, Canc Hosp & Inst, Beijing, Peoples R China.4 aut
7001 a Longshore, John W.u Atrium Hlth, Carolinas Pathol Grp, Charlotte, NC USA.4 aut
7001 a Motoi, Norikou Natl Canc Ctr, Dept Diagnost Pathol, Tokyo, Japan.4 aut
7001 a Noguchi, Masayukiu Univ Tsukuba, Dept Pathol, Tsukuba, Ibaraki, Japan.4 aut
7001 a Poleri, Claudiau Off Pathol Consultants, Buenos Aires, DF, Argentina.4 aut
7001 a Rekhtman, Natashau Mem Sloan Kettering Canc Ctr, Dept Pathol, 1275 York Ave, New York, NY 10021 USA.4 aut
7001 a Tsao, Ming-Soundu Univ Hlth Network, Princess Margaret Canc Ctr, Toronto, ON, Canada.4 aut
7001 a Thunnissen, Eriku Vrije Univ Amsterdam Med Ctr, Dept Pathol, Amsterdam, Netherlands.4 aut
7001 a Travis, William D.u Mem Sloan Kettering Canc Ctr, Dept Pathol, 1275 York Ave, New York, NY 10021 USA.4 aut
7001 a Yatabe, Yasushiu Natl Canc Ctr, Dept Diagnost Pathol, Tokyo, Japan.4 aut
7001 a Roden, Anja C.u Mayo Clin, Dept Lab Med & Pathol, Rochester, MN USA.4 aut
7001 a Daigneault, Jillian B.u Int Assoc Study Lung Canc, Aurora, CO USA.4 aut
7001 a Wistuba, Ignacio I.u Univ Texas MD Anderson Canc Ctr, Dept Pathol, Houston, TX 77030 USA.4 aut
7001 a Kerr, Keith M.u Aberdeen Royal Infirm, Dept Pathol, Aberdeen, Scotland.4 aut
7001 a Pass, Harveyu New York Univ Langone Hlth, Dept Surg, New York, NY 10016 USA.4 aut
7001 a Nicholson, Andrew G.u Royal Brompton & Harefield NHS Fdn Trust, Dept Pathol, London, England.;Imperial Coll, Natl Heart & Lung Inst, London, England.4 aut
7001 a Mino-Kenudson, Mariu Harvard Med Sch, Dept Pathol, Massachusetts Gen Hosp, Boston, MA 02115 USA.4 aut
7102 a New York Univ Langone Hlth, Dept Pathol, 560 First Ave,TH 4-15B, New York, NY 10016 USA.b New York Univ Langone Hlth, Dept Biostat, New York, NY 10016 USA.4 org
7730 t Journal of Thoracic Oncologyd : ELSEVIER SCIENCE INCg 15:10, s. 1599-1610q 15:10<1599-1610x 1556-0864x 1556-1380
8564 u http://www.jto.org/article/S1556086420304688/pdf
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-423938
8564 8u https://doi.org/10.1016/j.jtho.2020.06.001

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