WFRF:(Idland A. V.)
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 04555naa a2200661 4500 | |
| 001 | oai:gup.ub.gu.se/264394 | |
| 003 | SwePub | |
| 008 | 240528s2017 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://gup.ub.gu.se/publication/2643942 URI |
| 024 | 7 | a https://doi.org/10.1159/0004818532 DOI |
| 040 | a (SwePub)gu | |
| 041 | a eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Hov, K. R.4 aut |
| 245 | 1 0 | a Cerebrospinal Fluid S100B and Alzheimer's Disease Biomarkers in Hip Fracture Patients with Delirium |
| 264 | c 2017-11-09 | |
| 264 | 1 | b S. Karger AG,c 2017 |
| 520 | a Objectives: This study aimed to investigate the relationship between cerebrospinal fluid (CSF) S100B astrocyte-derived protein and delirium and to perform stratified analyses according to clinical and CSF markers of dementia. Methods: We performed a prospective cohort study in a university hospital setting. The participants were patients admitted for hip fracture (n = 98) or for elective surgery (n = 50). Delirium was assessed daily perioperatively in hip fracture patients using the Confusion Assessment Method. A consensus-based diagnosis of prefracture dementia was made using all available information. CSF was drawn at the onset of spinal anesthesia. S100B and phosphorylated tau (P-tau) concentrations were measured using electro-chemiluminescence immunoassay and enzyme-linked immunosorbent assays, respectively. Results: In the hip fracture population (n = 98) there was no significant difference in CSF S100B concentrations between patients with ongoing preoperative (i.e., prevalent) delirium (n = 36, median [interquartile range] 1.11 mu g/L [0.91-1.29]) and patients who never developed delirium (n = 46, 1.08 mu g/L [0.92-1.28], p = 0.92). In patients without preoperative delirium, those who developed delirium postoperatively (i.e., incident delirium) (n = 16, 1.38 mu g/L [1.08-1.62]) had higher concentrations of S100B than the 46 who never did (p = 0.013). This difference was confined to patients with pathological concentrations of P-tau (= 60 ng/L, n = 38). We also found that P-tau and S100B were correlated in CSF in the elective surgery patients. Conclusions: CSF S100B was elevated in patients with incident delirium who also had pathological levels of the Alzheimer disease biomarker P-tau, suggesting vulnerability caused by a preexisting process of astrocytic activation and tau pathology. (c) 2017 The Author(s) Published by S. Karger AG, Basel. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Neurologi0 (SwePub)302072 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Neurology0 (SwePub)302072 hsv//eng |
| 653 | a Delirium | |
| 653 | a S100B | |
| 653 | a Cerebrospinal fluid | |
| 653 | a Phosphorylated tau | |
| 653 | a Hip fracture | |
| 653 | a population-based cohort | |
| 653 | a cognitive decline | |
| 653 | a elderly-patients | |
| 653 | a serum | |
| 653 | a s100b | |
| 653 | a dementia | |
| 653 | a protein | |
| 653 | a metaanalysis | |
| 653 | a association | |
| 653 | a risk | |
| 653 | a tau | |
| 653 | a Neurosciences & Neurology | |
| 653 | a lstein mf | |
| 653 | a 1975 | |
| 653 | a journal of psychiatric research | |
| 653 | a v12 | |
| 653 | a p189 | |
| 700 | 1 | a Bolstad, N.4 aut |
| 700 | 1 | a Idland, A. V.4 aut |
| 700 | 1 | a Zetterberg, Henrik,d 1973u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry4 aut0 (Swepub:gu)xzethe |
| 700 | 1 | a Blennow, Kaj,d 1958u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry4 aut0 (Swepub:gu)xbleka |
| 700 | 1 | a Chaudhry, F. A.4 aut |
| 700 | 1 | a Frihagen, F.4 aut |
| 700 | 1 | a Raeder, J.4 aut |
| 700 | 1 | a Wyller, T. B.4 aut |
| 700 | 1 | a Watne, L. O.4 aut |
| 710 | 2 | a Göteborgs universitetb Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi4 org |
| 773 | 0 | t Dementia and Geriatric Cognitive Disorders Extrad : S. Karger AGg 7:3, s. 374-385q 7:3<374-385x 1664-5464 |
| 856 | 4 | u https://www.karger.com/Article/Pdf/481853 |
| 856 | 4 8 | u https://gup.ub.gu.se/publication/264394 |
| 856 | 4 8 | u https://doi.org/10.1159/000481853 |
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