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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00006058naa a2200697 4500
001oai:lup.lub.lu.se:6f873a72-d6db-471d-ab5f-48c956e80744
003SwePub
008230313s2023 | |||||||||||000 ||eng|
0247 a https://lup.lub.lu.se/record/6f873a72-d6db-471d-ab5f-48c956e807442 URI
0247 a https://doi.org/10.1002/acr.250902 DOI
040 a (SwePub)lu
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Clarke, Ann E.u University of Calgary4 aut
2451 0a Assessing the Costs of Neuropsychiatric Disease in the Systemic Lupus International Collaborating Clinics Cohort Using Multistate Modeling
264 c 2023-02-23
264 1b Wiley,c 2023
520 a Objective: To estimate direct and indirect costs associated with neuropsychiatric (NP) events in the Systemic Lupus International Collaborating Clinics inception cohort. Methods: NP events were documented annually using American College of Rheumatology definitions for NP events and attributed to systemic lupus erythematosus (SLE) or non-SLE causes. Patients were stratified into 1 of 3 NP states (no, resolved, or new/ongoing NP event). Change in NP status was characterized by interstate transition rates using multistate modeling. Annual direct costs and indirect costs were based on health care use and impaired productivity over the preceding year. Annual costs associated with NP states and NP events were calculated by averaging all observations in each state and adjusted through random-effects regressions. Five- and 10-year costs for NP states were predicted by multiplying adjusted annual costs per state by expected state duration, forecasted using multistate modeling. Results: A total of 1,697 patients (49% White race/ethnicity) were followed for a mean of 9.6 years. NP events (n = 1,971) occurred in 956 patients, 32% attributed to SLE. For SLE and non-SLE NP events, predicted annual, 5-, and 10-year direct costs and indirect costs were higher in new/ongoing versus no events. Direct costs were 1.5-fold higher and indirect costs 1.3-fold higher in new/ongoing versus no events. Indirect costs exceeded direct costs 3.0 to 5.2 fold. Among frequent SLE NP events, new/ongoing seizure disorder and cerebrovascular disease accounted for the largest increases in annual direct costs. For non-SLE NP events, new/ongoing polyneuropathy accounted for the largest increase in annual direct costs, and new/ongoing headache and mood disorder for the largest increases in indirect costs. Conclusion: Patients with new/ongoing SLE or non-SLE NP events incurred higher direct and indirect costs.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Reumatologi och inflammation0 (SwePub)302102 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Rheumatology and Autoimmunity0 (SwePub)302102 hsv//eng
7001 a Hanly, John G.u Dalhousie University4 aut
7001 a Urowitz, Murray B.u University of Toronto4 aut
7001 a St. Pierre, Yvanu McGill University Health Center4 aut
7001 a Gordon, Carolineu University of Birmingham4 aut
7001 a Bae, Sang Cheolu Hanyang University Hospital for Rheumatic Disease4 aut
7001 a Romero-Diaz, Juanitau Salvador Zubirán National Institute of Health Sciences and Nutrition4 aut
7001 a Sanchez-Guerrero, Jorgeu University of Toronto4 aut
7001 a Bernatsky, Sashau McGill University Health Center4 aut
7001 a Wallace, Daniel J.u University of California, Los Angeles4 aut
7001 a Isenberg, David A.u University College London4 aut
7001 a Rahman, Anisuru University College London4 aut
7001 a Merrill, Joan T.u Oklahoma Medical Research Foundation4 aut
7001 a Fortin, Paul R.u Centre hospitalier universitaire de Québec4 aut
7001 a Gladman, Dafna D.u University of Toronto4 aut
7001 a Bruce, Ian N.u Manchester Academic Health Science Centre4 aut
7001 a Petri, Michelleu Johns Hopkins University School of Medicine4 aut
7001 a Ginzler, Ellen M.u SUNY Downstate Health Sciences University4 aut
7001 a Dooley, Mary Anneu University of North Carolina4 aut
7001 a Ramsey-Goldman, Rosalindu Northwestern University4 aut
7001 a Manzi, Susanu Allegheny Health Network4 aut
7001 a Jönsen, Andreasu Lund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Lund SLE Research Group,Forskargrupper vid Lunds universitet,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University Research Groups4 aut0 (Swepub:lu)reum-ajo
7001 a Alarcón, Graciela S.u University of Alabama4 aut
7001 a Van Vollenhoven, Ronald F.u Academic Medical Center of University of Amsterdam (AMC)4 aut
7001 a Aranow, Cynthiau Feinstein Institute for Medical Research4 aut
7001 a Mackay, Megganu Feinstein Institute for Medical Research4 aut
7001 a Ruiz-Irastorza, Guillermou University of the Basque Country4 aut
7001 a Lim, S. Samu Emory University4 aut
7001 a Inanc, Muratu Istanbul University4 aut
7001 a Kalunian, Kenneth C.u University of California, San Diego4 aut
7001 a Jacobsen, Sorenu Copenhagen University Hospital4 aut
7001 a Peschken, Christine A.u University of Manitoba4 aut
7001 a Kamen, Diane L.u Medical University of South Carolina4 aut
7001 a Askanase, Ancau Indian Institute of Technology4 aut
7001 a Farewell, Vernonu University of Cambridge4 aut
7102 a University of Calgaryb Dalhousie University4 org
7730 t Arthritis Care and Researchd : Wileyg 75:9, s. 1859-1870q 75:9<1859-1870x 2151-464Xx 2151-4658
8564 u http://dx.doi.org/10.1002/acr.25090y FULLTEXT
8564 8u https://lup.lub.lu.se/record/6f873a72-d6db-471d-ab5f-48c956e80744
8564 8u https://doi.org/10.1002/acr.25090

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