Regulation of thermogenic capacity in brown and white adipocytes by the prebiotic high-esterified pectin and its postbiotic acetate

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Fältnamn	Indikatorer	Metadata
000		03876naa a2200385 4500
001		oai:DiVA.org:su-180628
003		SwePub
008		200418s2020 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-1806282 URI
024	7	a https://doi.org/10.1038/s41366-019-0445-62 DOI
040		a (SwePub)su
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a García-Carrizo, Francisco4 aut
245	1 0	a Regulation of thermogenic capacity in brown and white adipocytes by the prebiotic high-esterified pectin and its postbiotic acetate
264		c 2019-08-29
264	1	b Springer Science and Business Media LLC,c 2020
338		a print2 rdacarrier
520		a Objectives High-esterified pectin (HEP) is a prebiotic able to modulate gut microbiota, associated with health-promoting metabolic effects in glucose and lipid metabolism and adipostatic hormone sensitivity. Possible effects regulating adaptive thermogenesis and energy waste are poorly known. Therefore, we aimed to study how physiological supplementation with HEP is able to affect microbiota, energy metabolism and adaptive thermogenic capacity, and to contribute to the healthier phenotype promoted by HEP supplementation, as previously shown. We also attempted to decipher some of the mechanisms involved in the HEP effects, including in vitro experiments.Subjects and experimental design We used a model of metabolic malprogramming consisting of the progeny of rats with mild calorie restriction during pregnancy, both under control diet and an obesogenic (high-sucrose) diet, supplemented with HEP, combined with in vitro experiments in primary cultured brown and white adipocytes treated with the postbiotic acetate.Results Our main findings suggest that chronic HEP supplementation induces markers of brown and white adipose tissue thermogenic capacity, accompanied by a decrease in energy efficiency, and prevention of weight gain under an obesogenic diet. We also show that HEP promotes an increase in beneficial bacteria in the gut and peripheral levels of acetate. Moreover, in vitro acetate can improve adipokine production, and increase thermogenic capacity and browning in brown and white adipocytes, respectively, which could be part of the protection mechanism against excess weight gain observed in vivo.Conclusion HEP and acetate stand out as prebiotic/postbiotic active compounds able to modulate both brown-adipocyte metabolism and browning and protect against obesity.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Cell- och molekylärbiologi0 (SwePub)301082 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Cell and Molecular Biology0 (SwePub)301082 hsv//eng
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng
700	1	a Cannon, Barbarau Stockholms universitet,Institutionen för molekylär biovetenskap, Wenner-Grens institut4 aut0 (Swepub:su)canno
700	1	a Nedergaard, Janu Stockholms universitet,Institutionen för molekylär biovetenskap, Wenner-Grens institut4 aut0 (Swepub:su)neder
700	1	a Picó, Catalina4 aut
700	1	a Dols, Albert4 aut
700	1	a Rodríguez, Ana María4 aut
700	1	a Palou, Andreu4 aut
710	2	a Stockholms universitetb Institutionen för molekylär biovetenskap, Wenner-Grens institut4 org
773	0	t International Journal of Obesityd : Springer Science and Business Media LLCg 44:3, s. 715-726q 44:3<715-726x 0307-0565x 1476-5497
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-180628
856	4 8	u https://doi.org/10.1038/s41366-019-0445-6

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Av författaren/redakt...: García-Carrizo, ...; Cannon, Barbara; Nedergaard, Jan; Picó, Catalina; Dols, Albert; Rodríguez, Ana M ...; visa fler...; Palou, Andreu; visa färre...

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