Predictive value of sarcopenia components for all-cause mortality : findings from population-based cohorts

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Predictive value of sarcopenia components for all-cause mortality : findings from population-based cohorts

Westbury, Leo D. (författare): University of Southampton,Univ Southampton, MRC Lifecourse Epidemiol Ctr, Southampton, England.

Harvey, Nicholas C. (författare): University of Southampton,Univ Southampton, MRC Lifecourse Epidemiol Ctr, Southampton, England.;Univ Southampton, NIHR Southampton Biomed Res Ctr, Southampton, England.;Univ Hosp Southampton NHS Fdn Trust, Southampton, England.;Univ Oxford, NIHR Oxford Biomed Res Ctr, Oxford, England.

Beaudart, Charlotte (författare): Univ Namur, Namur Res Inst Life Sci NARILIS, Dept Biomed Sci, Fac Med,Clin Pharmacol & Toxicol Res Unit, B-5000 Namur, Belgium.

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Bruyère, Olivier (författare): University of Liège,Univ Liege, Dept Publ Hlth, Div Epidemiol Publ Hlth & Hlth Econ, Liege, Belgium.

Cauley, Jane A. (författare): University of Pittsburgh,Univ Pittsburgh, Sch Publ Hlth, Dept Epidemiol, Pittsburgh, PA USA.

Cawthon, Peggy (författare): California Pacific Medical Center,University of California, San Francisco,Calif Pacific Med Ctr, Res Inst, San Francisco, CA USA.;Univ Calif San Francisco, Dept Epidemiol & Biostat, San Francisco, CA USA.

Cruz-Jentoft, Alfonso J. (författare): Hospital Ramón Y Cajal,Hosp Univ Ramon y Cajal IRYCIS, Serv Geriatr, Madrid, Spain.

Curtis, Elizabeth M. (författare): University of Southampton,Univ Southampton, MRC Lifecourse Epidemiol Ctr, Southampton, England.

Ensrud, Kristine (författare): Univ Minnesota, Med & Epidemiol & Community Hlth, Minneapolis, MN USA.;Minneapolis VA Hlth Care Syst, Ctr Care Delivery & Outcomes Res, Minneapolis, MN USA.,University of Minnesota

Fielding, Roger A. (författare): Jean Mayer USDA Human Nutrition Research Center on Aging,Tufts Univ, Jean Mayer USDA Human Nutr Res Ctr Aging, Nutr Exercise Physiol & Sarcopenia Lab, Boston, MA USA.

Johansson, Helena (författare): University of Gothenburg,Australian Catholic University,Australian Catholic Univ, Mary MacKillop Inst Hlth Res, Melbourne, Australia.;Univ Gothenburg, Inst Med, Sahlgrenska Osteoporosis Ctr, Gothenburg, Sweden.

Kanis, John A. (författare): Australian Catholic University,University of Sheffield,Australian Catholic Univ, Mary MacKillop Inst Hlth Res, Melbourne, Australia.;Univ Sheffield, Ctr Metab Bone Dis, Sheffield, England.

Karlsson, Magnus K. (författare): Lund University,Lunds universitet,Ortopedi,Forskargrupper vid Lunds universitet,Orthopedics,Lund University Research Groups,Skåne University Hospital,Lund Univ, Dept Clin Sci Malmö, Clin & Mol Osteoporosis Res Unit, Dept Orthoped, Malmö, Sweden.;Skane Univ Hosp, Dept Orthoped, Malmö, Sweden.

Lane, Nancy E. (författare): University of California, Davis,UC Davis Hlth, Dept Internal Med, Div Rheumatol, 4625 Second Ave, Sacramento, CA 95917 USA.

Lengelé, Laetitia (författare): Catholic University of Louvain,Catholic Univ Louvain, UCLouvain, Louvain Drug Res Inst, Metab & Nutr Res Grp, B-1200 Sint Lambrechts Woluwe, Belgium.

Lorentzon, Mattias (författare): Sahlgrenska University Hospital,Australian Catholic University,Australian Catholic Univ, Mary MacKillop Inst Hlth Res, Melbourne, Australia.;Sahlgrens Univ Hosp, Inst Med, Sahlgrenska Acad, Ctr Osteoporosis Res, Mölndal, Sweden.

McCloskey, Eugene (författare): University of Sheffield,Australian Catholic University,Australian Catholic Univ, Mary MacKillop Inst Hlth Res, Melbourne, Australia.;Univ Sheffield, Ctr Integrated Res Musculoskeletal Ageing CIMA, Mellanby Ctr Bone Res, Sheffield, England.

Mellström, Dan (författare): Sahlgrenska Academy,Univ Gothenburg, Sahlgrenska Acad, Ctr Bone & Arthrit Res CBAR, Gothenburg, Sweden.

Newman, Anne B. (författare): University of Pittsburgh,Univ Pittsburgh, Sch Publ Hlth, Dept Epidemiol, Pittsburgh, PA USA.

Ohlsson, Claes (författare): Sahlgrenska Academy,Sahlgrenska University Hospital,Univ Gothenburg, Sahlgrenska Osteoporosis Ctr, Arthrit Res Sahlgrenska Acad, Inst Med,Dept Internal Med & Clin Nutr, Gothenburg, Sweden.;Sahlgrens Univ Hosp, Dept Drug Treatment, Reg Vastra Gotaland, Gothenburg, Sweden.

Orwoll, Eric (författare): Oregon Health & Science University,Oregon Hlth & Sci Univ, Portland, OR USA.

Reginster, Jean Yves (författare): King Saud Univ, Coll Sci, Prot Res Chair, Biochem Dept, Riyadh, Saudi Arabia.

Ribom, Eva (författare): Uppsala universitet,Uppsala University,Ortopedi och Handkirurgi

Rosengren, Björn E. (författare): Lund University,Lunds universitet,Ortopedi,Forskargrupper vid Lunds universitet,LU profilområde: Proaktivt åldrande,Lunds universitets profilområden,Orthopedics,Lund University Research Groups,LU Profile Area: Proactive Ageing,Lund University Profile areas,Skåne University Hospital,Lund Univ, Dept Clin Sci Malmö, Clin & Mol Osteoporosis Res Unit, Dept Orthoped, Malmö, Sweden.;Skane Univ Hosp, Dept Orthoped, Malmö, Sweden.

Schousboe, John T. (författare): University of Minnesota,Pk Nicollet Clin, Bloomington, MN USA.;HealthPartners Inst, Bloomington, MN USA.;Univ Minnesota, Minneapolis, MN USA.

Dennison, Elaine M. (författare): University of Southampton,Te Herenga Waka / Victoria University of Wellington,Univ Southampton, MRC Lifecourse Epidemiol Ctr, Southampton, England.;Univ Southampton, NIHR Southampton Biomed Res Ctr, Southampton, England.;Univ Hosp Southampton NHS Fdn Trust, Southampton, England.;Victoria Univ Wellington, Wellington, New Zealand.

Cooper, Cyrus (författare): University of Oxford,University of Southampton

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University of Southampton Univ Southampton, MRC Lifecourse Epidemiol Ctr, Southampton, England (creator_code:org_t)

Springer, 2024
2024
Engelska.
Ingår i: Aging clinical and experimental research. - : Springer. - 1594-0667 .- 1720-8319. ; 36:1

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Background: Low grip strength and gait speed are associated with mortality. However, investigation of the additional mortality risk explained by these measures, over and above other factors, is limited. Aim: We examined whether grip strength and gait speed improve discriminative capacity for mortality over and above more readily obtainable clinical risk factors. Methods: Participants from the Health, Aging and Body Composition Study, Osteoporotic Fractures in Men Study, and the Hertfordshire Cohort Study were analysed. Appendicular lean mass (ALM) was ascertained using DXA; muscle strength by grip dynamometry; and usual gait speed over 2.4–6 m. Verified deaths were recorded. Associations between sarcopenia components and mortality were examined using Cox regression with cohort as a random effect; discriminative capacity was assessed using Harrell’s Concordance Index (C-index). Results: Mean (SD) age of participants (n = 8362) was 73.8(5.1) years; 5231(62.6%) died during a median follow-up time of 13.3 years. Grip strength (hazard ratio (95% CI) per SD decrease: 1.14 (1.10,1.19)) and gait speed (1.21 (1.17,1.26)), but not ALM index (1.01 (0.95,1.06)), were associated with mortality in mutually-adjusted models after accounting for age, sex, BMI, smoking status, alcohol consumption, physical activity, ethnicity, education, history of fractures and falls, femoral neck bone mineral density (BMD), self-rated health, cognitive function and number of comorbidities. However, a model containing only age and sex as exposures gave a C-index (95% CI) of 0.65(0.64,0.66), which only increased to 0.67(0.67,0.68) after inclusion of grip strength and gait speed. Conclusions: Grip strength and gait speed may generate only modest adjunctive risk information for mortality compared with other more readily obtainable risk factors.

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Predictive value of sarcopenia components for all-cause mortality : findings from population-based cohorts

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