On the Definition of Sarcopenia in the Presence of Aging and Obesity-Initial Results from UK Biobank

↓ Direkt till sidans innehåll
↓ Direkt till sidans sekundära innehåll (sidomenyn)

Sökning: WFRF:(Heymsfield Steven) > On the Definition o...

LIBRIS Formathandbok (Information om MARC21)

Fältnamn	Indikatorer	Metadata
000		04565naa a2200409 4500
001		oai:DiVA.org:liu-169056
003		SwePub
008		200907s2020 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-1690562 URI
024	7	a https://doi.org/10.1093/gerona/glz2292 DOI
040		a (SwePub)liu
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Linge, Jenniferu Linköpings universitet,Avdelningen för samhälle och hälsa,Medicinska fakulteten,AMRA Medical AB, Sweden4 aut0 (Swepub:liu)jenli83
245	1 0	a On the Definition of Sarcopenia in the Presence of Aging and Obesity-Initial Results from UK Biobank
264		c 2019-10-23
264	1	b Oxford University Press,c 2020
338		a electronic2 rdacarrier
500		a Funding agencies: Medical Research CouncilMedical Research Council UK (MRC) [MC_PC_17228, MC_QA137853] Funding Source: Medline
520		a BACKGROUND: Current consensus is to combine a functional measure with muscle quantity to assess/confirm sarcopenia. However, the proper body size adjustment for muscle quantity is debated and sarcopenia in obesity is not well described. Further, functional measures are not muscle-specific or sensitive to etiology, and can be confounded by, for example, fitness/pain. For effective detection/treatment/follow-up, muscle-specific biomarkers linked to function are needed.METHODS: Nine thousand six hundred and fifteen participants were included and current sarcopenia thresholds (EWGSOP2: DXA, hand grip strength) applied to investigate prevalence. Fat-tissue free muscle volume (FFMV) and muscle fat infiltration (MFI) were quantified through magnetic resonance imaging (MRI) and sex-and-body mass index (BMI)-matched virtual control groups (VCGs) were used to extract each participant's FFMV/height2 z-score (FFMVVCG). The value of combining FFMVVCG and MFI was investigated through hospital nights, hand grip strength, stair climbing, walking pace, and falls.RESULTS: Current thresholds showed decreased sarcopenia prevalence with increased BMI (underweight 8.5%/normal weight 4.3%/overweight 1.1%/obesity 0.1%). Contrary, the prevalence of low function increased with increasing BMI. Previously proposed body size adjustments (division by height2/weight/BMI) introduced body size correlations of larger/similar magnitude than before. VCG adjustment achieved normalization and strengthened associations with hospitalization/function. Hospital nights, low hand grip strength, slow walking pace, and no stair climbing were positively associated with MFI (p < .05) and negatively associated with FFMVVCG (p < .01). Only MFI was associated with falls (p < .01). FFMVVCG and MFI combined resulted in highest diagnostic performance detecting low function.CONCLUSIONS: VCG-adjusted FFMV enables proper sarcopenia assessment across BMI classes and strengthened the link to function. MFI and FFMV combined provides a more complete, muscle-specific description linked to function enabling objective sarcopenia detection.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskapx Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi0 (SwePub)303022 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Health Sciencesx Public Health, Global Health, Social Medicine and Epidemiology0 (SwePub)303022 hsv//eng
653		a Dual-energy x-ray absorptiometry
653		a Imaging biomarkers
653		a Magnetic resonance imaging
653		a Muscle fat infiltration
653		a Sarcopenic obesity
700	1	a Heymsfield, Steven B.u Pennington Biomedical Research Center, USA4 aut
700	1	a Dahlqvist Leinhard, Olof,d 1978-u Linköpings universitet,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,Centrum för medicinsk bildvetenskap och visualisering, CMIV,AMRA Medical AB, Sweden4 aut0 (Swepub:liu)oloda24
710	2	a Linköpings universitetb Avdelningen för samhälle och hälsa4 org
773	0	t The journals of gerontology. Series A, Biological sciences and medical sciencesd : Oxford University Pressg 75:7, s. 1309-1316q 75:7<1309-1316x 1079-5006x 1758-535X
856	4	u https://liu.diva-portal.org/smash/get/diva2:1464637/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
856	4	u https://academic.oup.com/biomedgerontology/article-pdf/75/7/1309/33403504/glz229.pdf
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-169056
856	4 8	u https://doi.org/10.1093/gerona/glz229

Hitta via bibliotek

The journals of gerontology. Series A, Biological sciences and medical sciences (Sök värdpublikationen i LIBRIS)

Till lärosätets databas

Hitta mer i SwePub

Av författaren/redakt...: Linge, Jennifer; Heymsfield, Stev ...; Dahlqvist Leinha ...

Om ämnet

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Hälsovetenskap; och Folkhälsovetensk ...

Artiklar i publikationen: The journals of ...

Av lärosätet: Linköpings universitet

Sök utanför SwePub

Sök vidare i:: Google; Google Book Search; Google Scholar

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

LIBRIS.kb.se