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000 | 07789naa a22019693a 4500 | |
001 | l0r9xv1cj3p4p61l | |
003 | SE-LIBR | |
005 | 20210618233144.0 | |
007 | cr ||| ||||| | |
008 | 210618s2021 sw |||||o||||o000 ||eng|c | |
024 | 7 | a urn:nbn:se:uu:diva-4458222 urn |
024 | 7 | a 10.1093/hmg/ddab0232 doi |
024 | 7 | a http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4458222 uri |
040 | a Se a | |
041 | a eng | |
042 | 9 EPLK | |
100 | 1 | a Ahluwalia, Tarunveer S.4 aut |
245 | 1 0 | a Genome-wide association study of circulating interleukin 6 levels identifies novel locih [Elektronisk resurs] |
264 | 1 | b Oxford University Press (OUP),c 2021 |
500 | a Published | |
506 | 0 | a gratis |
520 | a Interleukin 6 (IL-6) is a multifunctional cytokine with both pro- and anti-inflammatory properties with a heritability estimate of up to 61%. The circulating levels of IL-6 in blood have been associated with an increased risk of complex disease pathogenesis. We conducted a two-staged, discovery and replication meta genome-wide association study (GWAS) of circulating serum IL-6 levels comprising up to 67428 (n(discovery)=52654 and n(replication)=14774) individuals of European ancestry. The inverse variance fixed effects based discovery meta-analysis, followed by replication led to the identification of two independent loci, IL1F10/IL1RN rs6734238 on chromosome (Chr) 2q14, (P-combined=1.8x10(-11)), HLA-DRB1/DRB5 rs660895 on Chr6p21 (P-combined=1.5x10(-10)) in the combined meta-analyses of all samples. We also replicated the IL6R rs4537545 locus on Chr1q21 (P-combined=1.2x10(-122)). Our study identifies novel loci for circulating IL-6 levels uncovering new immunological and inflammatory pathways that may influence IL-6 pathobiology. | |
650 | 7 | a Medical and Health Sciences2 hsv |
650 | 7 | a Basic Medicine2 hsv |
650 | 7 | a Medical Genetics2 hsv |
650 | 7 | a Medicin och hälsovetenskap2 hsv |
650 | 7 | a Medicinska och farmaceutiska grundvetenskaper2 hsv |
650 | 7 | a Medicinsk genetik2 hsv |
655 | 7 | a government publication2 marcgt |
700 | 1 | a Prins, Bram P.4 aut |
700 | 1 | a Abdollahi, Mohammadreza4 aut |
700 | 1 | a Armstrong, Nicola J.4 aut |
700 | 1 | a Aslibekyan, Stella4 aut |
700 | 1 | a Bain, Lisa4 aut |
700 | 1 | a Jefferis, Barbara4 aut |
700 | 1 | a Baumert, Jens4 aut |
700 | 1 | a Beekman, Marian4 aut |
700 | 1 | a Ben-Shlomo, Yoav4 aut |
700 | 1 | a Bis, Joshua C.4 aut |
700 | 1 | a Mitchell, Braxton D.4 aut |
700 | 1 | a de Geus, Eco4 aut |
700 | 1 | a Delgado, Graciela E.4 aut |
700 | 1 | a Marek, Diana4 aut |
700 | 1 | a Eriksson, Joel4 aut |
700 | 1 | a Kajantie, Eero4 aut |
700 | 1 | a Kanoni, Stavroula4 aut |
700 | 1 | a Kemp, John P.4 aut |
700 | 1 | a Lu, Chen4 aut |
700 | 1 | a Marioni, Riccardo E.4 aut |
700 | 1 | a McLachlan, Stela4 aut |
700 | 1 | a Milaneschi, Yuri4 aut |
700 | 1 | a Nolte, Ilja M.4 aut |
700 | 1 | a Petrelis, Alexandros M.4 aut |
700 | 1 | a Porcu, Eleonora4 aut |
700 | 1 | a Sabater-Lleal, Maria4 aut |
700 | 1 | a Naderi, Elnaz4 aut |
700 | 1 | a Seppala, Ilkka4 aut |
700 | 1 | a Shah, Tina4 aut |
700 | 1 | a Singhal, Gaurav4 aut |
700 | 1 | a Standl, Marie4 aut |
700 | 1 | a Teumer, Alexander4 aut |
700 | 1 | a Thalamuthu, Anbupalam4 aut |
700 | 1 | a Thiering, Elisabeth4 aut |
700 | 1 | a Trompet, Stella4 aut |
700 | 1 | a Ballantyne, Christie M.4 aut |
700 | 1 | a Benjamin, Emelia J.4 aut |
700 | 1 | a Casas, Juan P.4 aut |
700 | 1 | a Toben, Catherine4 aut |
700 | 1 | a Dedoussis, George4 aut |
700 | 1 | a Deelen, Joris4 aut |
700 | 1 | a Durda, Peter4 aut |
700 | 1 | a Engmann, Jorgen4 aut |
700 | 1 | a Feitosa, Mary F.4 aut |
700 | 1 | a Grallert, Harald4 aut |
700 | 1 | a Hammarstedt, Ann4 aut |
700 | 1 | a Harris, Sarah E.4 aut |
700 | 1 | a Homuth, Georg4 aut |
700 | 1 | a Hottenga, Jouke-Jan4 aut |
700 | 1 | a Jalkanen, Sirpa4 aut |
700 | 1 | a Jamshidi, Yalda4 aut |
700 | 1 | a Jawahar, Magdalene C.4 aut |
700 | 1 | a Jess, Tine4 aut |
700 | 1 | a Kivimaki, Mika4 aut |
700 | 1 | a Kleber, Marcus E.4 aut |
700 | 1 | a Lahti, Jari4 aut |
700 | 1 | a Liu, Yongmei4 aut |
700 | 1 | a Marques-Vidal, Pedro4 aut |
700 | 1 | a Mellstrom, Dan4 aut |
700 | 1 | a Mooijaart, Simon P.4 aut |
700 | 1 | a Muller-Nurasyid, Martina4 aut |
700 | 1 | a Penninx, Brenda4 aut |
700 | 1 | a Revez, Joana A.4 aut |
700 | 1 | a Rossing, Peter4 aut |
700 | 1 | a Raikkonen, Katri4 aut |
700 | 1 | a Sattar, Naveed4 aut |
700 | 1 | a Scharnagl, Hubert4 aut |
700 | 1 | a Sennblad, Bengt4 aut |
700 | 1 | a Silveira, Angela4 aut |
700 | 1 | a St Pourcain, Beate4 aut |
700 | 1 | a Timpson, Nicholas J.4 aut |
700 | 1 | a Trollor, Julian4 aut |
700 | 1 | a van Dongen, Jenny4 aut |
700 | 1 | a Van Heemst, Diana4 aut |
700 | 1 | a Visvikis-Siest, Sophie4 aut |
700 | 1 | a Vollenweider, Peter4 aut |
700 | 1 | a Volker, Uwe4 aut |
700 | 1 | a Waldenberger, Melanie4 aut |
700 | 1 | a Willemsen, Gonneke4 aut |
700 | 1 | a Zabaneh, Delilah4 aut |
700 | 1 | a Morris, Richard W.4 aut |
700 | 1 | a Arnett, Donna K.4 aut |
700 | 1 | a Baune, Bernhard T.4 aut |
700 | 1 | a Boomsma, Dorret4 aut |
700 | 1 | a Chang, Yen-Pei C.4 aut |
700 | 1 | a Deary, Ian J.4 aut |
700 | 1 | a Deloukas, Panos4 aut |
700 | 1 | a Eriksson, Johan G.4 aut |
700 | 1 | a Evans, David M.4 aut |
700 | 1 | a Ferreira, Manuel A.4 aut |
700 | 1 | a Gaunt, Tom4 aut |
700 | 1 | a Gudnason, Vilmundur4 aut |
700 | 1 | a Hamsten, Anders4 aut |
700 | 1 | a Heinrich, Joachim4 aut |
700 | 1 | a Hingorani, Aroon4 aut |
700 | 1 | a Humphries, Steve E.4 aut |
700 | 1 | a Jukema, J. Wouter4 aut |
700 | 1 | a Koenig, Wolfgang4 aut |
700 | 1 | a Kumari, Meena4 aut |
700 | 1 | a Kutalik, Zoltan4 aut |
700 | 1 | a Lawlor, Deborah A.4 aut |
700 | 1 | a Lehtimaki, Terho4 aut |
700 | 1 | a Marz, Winfried4 aut |
700 | 1 | a Mather, Karen A.4 aut |
700 | 1 | a Naitza, Silvia4 aut |
700 | 1 | a Nauck, Matthias4 aut |
700 | 1 | a Ohlsson, Claes4 aut |
700 | 1 | a Price, Jackie F.4 aut |
700 | 1 | a Raitakari, Olli4 aut |
700 | 1 | a Rice, Ken4 aut |
700 | 1 | a Sachdev, Perminder S.4 aut |
700 | 1 | a Slagboom, Eline4 aut |
700 | 1 | a Sorensen, Thorkild I. A.4 aut |
700 | 1 | a Spector, Tim4 aut |
700 | 1 | a Stacey, David4 aut |
700 | 1 | a Stathopoulou, Maria G.4 aut |
700 | 1 | a Tanaka, Toshiko4 aut |
700 | 1 | a Wannamethee, S. Goya4 aut |
700 | 1 | a Whincup, Peter4 aut |
700 | 1 | a Rotter, Jerome4 aut |
700 | 1 | a Dehghan, Abbas4 aut |
700 | 1 | a Boerwinkle, Eric4 aut |
700 | 1 | a Psaty, Bruce M.4 aut |
700 | 1 | a Snieder, Harold4 aut |
700 | 1 | a Alizadeh, Behrooz Z.4 aut |
710 | 1 | a Uppsala universitetb Teknisk-naturvetenskapliga vetenskapsområdet4 pbl |
710 | 1 | a Uppsala universitetb Science for Life Laboratory, SciLifeLab4 pbl |
772 | 0 8 | i channel recordw vd6k7sz65jh4wq2 |
773 | 0 | t Human Molecular Geneticsg 30:5, 393-409x 0964-6906 |
856 | 4 0 | u http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-445822 |
856 | 4 0 | u http://dx.doi.org/10.1093/hmg/ddab023 |
856 | 4 0 | u http://uu.diva-portal.org/smash/get/diva2:1568275/FULLTEXT01 |
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024 | 7 | 5 APISa urn:nbn:se:uu:diva-4458222 urn |
852 | 5 APISb APIS | |
856 | 4 0 | 5 APISu http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-445822 |
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