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WFRF:(Besser Rachel E J)
 

Sökning: WFRF:(Besser Rachel E J) > SARS-CoV-2 Infectio...

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FältnamnIndikatorerMetadata
00005980naa a2200529 4500
001oai:lup.lub.lu.se:9c7e0f0f-7442-411e-a0c2-32bad59098b3
003SwePub
008230920s2023 | |||||||||||000 ||eng|
0247 a https://lup.lub.lu.se/record/9c7e0f0f-7442-411e-a0c2-32bad59098b32 URI
0247 a https://doi.org/10.1001/jama.2023.163482 DOI
040 a (SwePub)lu
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Lugar, Marijau Dresden University of Technology4 aut
2451 0a SARS-CoV-2 Infection and Development of Islet Autoimmunity in Early Childhood
264 1c 2023
300 a 10 s.
520 a IMPORTANCE: The incidence of diabetes in childhood has increased during the COVID-19 pandemic. Elucidating whether SARS-CoV-2 infection is associated with islet autoimmunity, which precedes type 1 diabetes onset, is relevant to disease etiology and future childhood diabetes trends.OBJECTIVE: To determine whether there is a temporal relationship between SARS-CoV-2 infection and the development of islet autoimmunity in early childhood.DESIGN, SETTING, AND PARTICIPANTS: Between February 2018 and March 2021, the Primary Oral Insulin Trial, a European multicenter study, enrolled 1050 infants (517 girls) aged 4 to 7 months with a more than 10% genetically defined risk of type 1 diabetes. Children were followed up through September 2022.EXPOSURE: SARS-CoV-2 infection identified by SARS-CoV-2 antibody development in follow-up visits conducted at 2- to 6-month intervals until age 2 years from April 2018 through June 2022.MAIN OUTCOMES AND MEASURES: The development of multiple (≥2) islet autoantibodies in follow-up in consecutive samples or single islet antibodies and type 1 diabetes. Antibody incidence rates and risk of developing islet autoantibodies were analyzed.RESULTS: Consent was obtained for 885 (441 girls) children who were included in follow-up antibody measurements from age 6 months. SARS-CoV-2 antibodies developed in 170 children at a median age of 18 months (range, 6-25 months). Islet autoantibodies developed in 60 children. Six of these children tested positive for islet autoantibodies at the same time as they tested positive for SARS-CoV-2 antibodies and 6 at the visit after having tested positive for SARS-CoV-2 antibodies. The sex-, age-, and country-adjusted hazard ratio for developing islet autoantibodies when the children tested positive for SARS-CoV-2 antibodies was 3.5 (95% CI, 1.6-7.7; P = .002). The incidence rate of islet autoantibodies was 3.5 (95% CI, 2.2-5.1) per 100 person-years in children without SARS-CoV-2 antibodies and 7.8 (95% CI, 5.3-19.0) per 100 person-years in children with SARS-CoV-2 antibodies (P = .02). Islet autoantibody risk in children with SARS-CoV-2 antibodies was associated with younger age (<18 months) of SARS-CoV-2 antibody development (HR, 5.3; 95% CI, 1.5-18.3; P = .009).CONCLUSION AND RELEVANCE: In young children with high genetic risk of type 1 diabetes, SARS-CoV-2 infection was temporally associated with the development of islet autoantibodies.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng
7001 a Eugster, Anneu Dresden University of Technology4 aut
7001 a Achenbach, Peteru Helmholtz Zentrum München,Technical University of Munich4 aut
7001 a von dem Berge, Theklau Children's Hospital Auf der Bult4 aut
7001 a Berner, Reinhardu University Clinic Carl Gustav Carus at the TU Dresden4 aut
7001 a Besser, Rachel E Ju Oxford University Hospital4 aut
7001 a Casteels, Kristinau Catholic University of Leuven,University Hospitals Leuven4 aut
7001 a Elding Larsson, Helenau Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Pediatrisk endokrinologi,Forskargrupper vid Lunds universitet,Department of Clinical Sciences, Malmö,Faculty of Medicine,Paediatric Endocrinology,Lund University Research Groups,Skåne University Hospital4 aut0 (Swepub:lu)pedi-hla
7001 a Gemulla, Gitau University Clinic Carl Gustav Carus at the TU Dresden,Dresden University of Technology4 aut
7001 a Kordonouri, Olgau Children's Hospital Auf der Bult4 aut
7001 a Lindner, Annettu Dresden University of Technology4 aut
7001 a Lundgren, Markusu Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Pediatrisk endokrinologi,Forskargrupper vid Lunds universitet,Department of Clinical Sciences, Malmö,Faculty of Medicine,Paediatric Endocrinology,Lund University Research Groups,Central Hospital Kristianstad4 aut0 (Swepub:lu)med-mn2
7001 a Müller, Deniseu Dresden University of Technology4 aut
7001 a Oltarzewski, Mariuszu National Research Institute of Mother and Child4 aut
7001 a Rochtus, Anneu Catholic University of Leuven,University Hospitals Leuven4 aut
7001 a Scholz, Marlonu Technical University of Munich,Helmholtz Zentrum München4 aut
7001 a Szypowska, Agnieszkau Medical University of Warsaw4 aut
7001 a Todd, John Au University of Oxford4 aut
7001 a Ziegler, Anette-Gabrieleu Technical University of Munich,Helmholtz Zentrum München4 aut
7001 a Bonifacio, Eziou University Clinic Carl Gustav Carus at the TU Dresden,Helmholtz Zentrum München,Dresden University of Technology4 aut
7102 a Dresden University of Technologyb Helmholtz Zentrum München4 org
7102 a GPPAD Study Group
7730 t JAMAg 330:12q 330:12x 0098-7484
8564 u http://dx.doi.org/10.1001/jama.2023.16348y FULLTEXT
8564 8u https://lup.lub.lu.se/record/9c7e0f0f-7442-411e-a0c2-32bad59098b3
8564 8u https://doi.org/10.1001/jama.2023.16348

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