WFRF:(Kettunen Petronella)
Sökning: WFRF:(Kettunen Petronella) > (2015-2019) > QKI6B mRNA levels a...
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 04528naa a2200613 4500 | |
| 001 | oai:gup.ub.gu.se/257760 | |
| 003 | SwePub | |
| 008 | 240528s2017 | |||||||||||000 ||eng| | |
| 009 | oai:DiVA.org:uu-334037 | |
| 024 | 7 | a https://gup.ub.gu.se/publication/2577602 URI |
| 024 | 7 | a https://doi.org/10.1016/j.brainres.2017.05.0272 DOI |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3340372 URI |
| 040 | a (SwePub)gud (SwePub)uu | |
| 041 | a eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Farnsworth, B.,d 1987-u Uppsala universitet,Evolution och utvecklingsbiologi4 aut0 (Swepub:uu)bryfa528 |
| 245 | 1 0 | a QKI6B mRNA levels are upregulated in schizophrenia and predict GFAP expression |
| 264 | 1 | b Elsevier BV,c 2017 |
| 520 | a Schizophrenia is a highly heritable disorder with a heterogeneous symptomatology. Research increasingly indicates the importance of the crucial and often overlooked glial perturbations within schizophrenia. Within this study, we examined an isoform of quaking (a gene encoding an RNA-binding protein that is exclusively expressed in glial cells), known as QKI6B, and a prototypical astrocyte marker, glial fibrillary acidic protein (GFAP), postulated to be under the regulation of QKI. The expression levels of these genes were quantified across post-mortem brain samples from 55 schizophrenic individuals, and 55 healthy controls, using real-time PCR. We report, through an analysis of covariance (ANCOVA) model, an upregulation of both QKI6B, and GFAP in the prefrontal cortex of brain samples of schizophrenic individuals, as compared to control samples. Previous research has suggested that the QKI protein directly regulates the expression of several genes through interaction with a motif in the target's sequence, termed the Quaking Response Element (QRE). We therefore examined if QICI6B expression can predict the outcome of GFAP, and several oligodendrocyte-related genes, using a multiple linear regression approach. We found that QKI6B significantly predicts the expression of GFAP, but does not predict oligodendrocyte-related gene outcome, as previously seen with other QKI isoforms. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Neurologi0 (SwePub)302072 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Neurology0 (SwePub)302072 hsv//eng |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Neurovetenskaper0 (SwePub)301052 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Neurosciences0 (SwePub)301052 hsv//eng |
| 653 | a Schizophrenia | |
| 653 | a Glia | |
| 653 | a Astrocytes | |
| 653 | a qPCR | |
| 653 | a ANCOVA | |
| 653 | a Regression | |
| 653 | a fibrillary-acidic-protein | |
| 653 | a anterior cingulate cortex | |
| 653 | a prefrontal cortex | |
| 653 | a bipolar disorder | |
| 653 | a glutamine-synthetase | |
| 653 | a subgenual cingulate | |
| 653 | a synaptic | |
| 653 | a proteins | |
| 653 | a serine racemase | |
| 653 | a frontal-cortex | |
| 653 | a star protein | |
| 653 | a Neurosciences & Neurology | |
| 653 | a Schizophrenia | |
| 700 | 1 | a Radomska, K.J.d 1984-u Uppsala universitet,Evolution och utvecklingsbiologi,IBENS, Dept Biol, Paris, France.4 aut0 (Swepub:uu)katra417 |
| 700 | 1 | a Zimmermann, B.u Uppsala universitet,Evolution och utvecklingsbiologi4 aut |
| 700 | 1 | a Kettunen, Petronellau Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry,Univ Gothenburg, Sahlgrenska Acad, Dept Psychiat & Neurochem, Inst Neurosci & Physiol, Gothenburg, Sweden.;Univ Oxford, John Radcliffe Hosp, Nuffield Dept Clin Neurosci, Dept Neuropathol, Oxford, England.4 aut0 (Swepub:gu)xketpe |
| 700 | 1 | a Jazin, E.u Uppsala universitet,Evolution och utvecklingsbiologi4 aut0 (Swepub:uu)elenjazi |
| 700 | 1 | a Emilsson, L.S.u Uppsala universitet,Evolution och utvecklingsbiologi4 aut0 (Swepub:uu)linaemil |
| 710 | 2 | a Uppsala universitetb Evolution och utvecklingsbiologi4 org |
| 773 | 0 | t Brain Researchd : Elsevier BVg 1669, s. 63-68q 1669<63-68x 0006-8993x 1872-6240 |
| 856 | 4 8 | u https://gup.ub.gu.se/publication/257760 |
| 856 | 4 8 | u https://doi.org/10.1016/j.brainres.2017.05.027 |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-334037 |
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