Brief Report: alterations in cerebral blood flow as assessed by PET/CT in adults with autism spectrum disorder with normal IQ

Brief Report : alterations in cerebral blood flow as assessed by PET/CT in adults with autism spectrum disorder with normal IQ

Pagani, Marco (author): Department of Nuclear Medicine, Karolinska University, Stockholm, Sweden; Institute of Cognitive Sciences and Technologies CNR, Rome, Italy

Odh, Richard (author): Department of Nuclear Medicine, Karolinska University, Stockholm, Sweden

Salmaso, Dario (author): Institute of Cognitive Sciences and Technologies CNR, Rome, Italy

Hatherly, Robert (author): Department of Nuclear Medicine, Karolinska University, Stockholm, Sweden

Brolin, Fredrik (author): Department of Nuclear Medicine, Karolinska University, Stockholm, Sweden

Larsson, Stig A. (author): Department of Nuclear Medicine, Karolinska University, Stockholm, Sweden

(creator_code:org_t)

2011-04-13
2012
English.
In: Journal of autism and developmental disorders. - New York, USA : Springer. - 0162-3257 .- 1573-3432. ; 42:2, s. 313-318

Related links:: https://urn.kb.se/re...; show more...; https://doi.org/10.1...; http://kipublication...; show less...

Abstract Subject headings

Specific biological markers for autism spectrum disorder (ASD) have not yet been established. Functional studies have shown abnormalities in the anatomo-functional connectivity of the limbic-striatal "social" brain. This study aimed to investigate regional cerebral blood flow (rCBF) at rest. Thirteen patients with ASD of normal intelligence and ten IQ-, sex- and age-matched healthy controls (HC) underwent PET/CT using [1-(11)C]butanol, a perfusion tracer. As compared to HC, ASD showed significant CBF increases in the right parahippocampal, posterior cingulate, primary visual and temporal cortex, putamen, caudatus, substantia nigra and cerebellum. No statistically significant correlation between CBF and IQ was found. The limbic, posterior associative and cerebellar cortices showed increased blood flow in ASD, confirming previous findings about the neurobiology of ASD.

By the author/editor: Pagani, Marco; Manouilenko, Iri ...; Stone-Elander, S ...; Odh, Richard; Salmaso, Dario; Hatherly, Robert; show more...; Brolin, Fredrik; Jacobsson, Hans; Larsson, Stig A.; Bejerot, Susanne ...; show less...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Psychiatry

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Neurology

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