Bacterial diversity in medication-related osteonecrosis of the jaw

Hallmer, Fredrik (författare): Malmö högskola,Odontologiska fakulteten (OD),Department of Oral and Maxillofacial Surgery, Skåne University Hospital, Lund, Sweden

Bjørnland, Tore (författare): Department of Oral Surgery and Oral Medicine, Faculty of Dentistry, University of Oslo, Oslo, Norway

Andersson, Gunilla (författare): Malmö högskola,Odontologiska fakulteten (OD)

Kristoffersen, Anne K. (författare): Senior Engineer, Department of Oral Biology, Faculty of Dentistry, University of Oslo, Oslo, Norway

Enersen, Morten (författare): Department of Oral Biology, Faculty of Dentistry, University of Oslo, Oslo, Norway

(creator_code:org_t)

Elsevier, 2017
2017
Engelska.
Ingår i: Oral surgery, oral medicine, oral pathology and oral radiology. - : Elsevier. - 2212-4403 .- 2212-4411. ; 123:4, s. 436-444

Relaterad länk:: https://urn.kb.se/re...; visa fler...; https://doi.org/10.1...; visa färre...

Abstract Ämnesord

Stäng

Objective. The aim was to study the association between microflora and medication-related osteonecrosis of the jaw (MRONJ) by using culture-independent molecular techniques to detect bacteria in necrotic bone lesions. Study Design. Included were 18 consecutive patients with MRONJ, 10 with osteoporosis and 8 cancer patients. Bone biopsies were retrieved from the center of the necrotic bone and from visually healthy bone, and 16 S rRNA gene fragments from bacterial DNA were amplified with polymerase chain reaction. Results. The study revealed a diversity of bacteria represented by 16 S rRNA sequences in all the necrotic bone samples and in 60% of the visually healthy bone. Eight dominating taxa groups were identified at the genus level: Porphyromonas, Lactobacillus, Tannerella, Prevotella, Actinomyces, Treponema, Streptococcus, and Fusobacterium. Conclusions. The necrotic bone lesions contained mainly anaerobic bacteria, representative of periodontal microflora, suggesting that a periodontal infection in combination with antiresorptive treatment could initiate osteonecrosis.

Av författaren/redakt...: Hallmer, Fredrik; Bjørnland, Tore; Andersson, Gunil ...; Becktor, Jonas P; Kristoffersen, A ...; Enersen, Morten

Om ämnet

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Odontologi

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