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Sökning: WFRF:(Hua Y) > (2020-2024) > Lysosomal lipoprote...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00006583naa a2200685 4500
001oai:DiVA.org:umu-186316
003SwePub
008210722s2021 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1863162 URI
0247 a https://doi.org/10.1016/j.cmet.2020.12.0012 DOI
040 a (SwePub)umu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Fischer, Alexander W.u Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Department of Molecular Metabolism, Harvard T. H. Chan School of Public Health, MA, Boston, United States; Department of Cell Biology, Harvard Medical School, MA, Boston, United States4 aut
2451 0a Lysosomal lipoprotein processing in endothelial cells stimulates adipose tissue thermogenic adaptation
264 1b Elsevier,c 2021
338 a print2 rdacarrier
520 a In response to cold exposure, thermogenic adipocytes internalize large amounts of fatty acids after lipoprotein lipase-mediated hydrolysis of triglyceride-rich lipoproteins (TRL) in the capillary lumen of brown adipose tissue (BAT) and white adipose tissue (WAT). Here, we show that in cold-exposed mice, vascular endothelial cells in adipose tissues endocytose substantial amounts of entire TRL particles. These lipoproteins subsequently follow the endosomal-lysosomal pathway, where they undergo lysosomal acid lipase (LAL)-mediated processing. Endothelial cell-specific LAL deficiency results in impaired thermogenic capacity as a consequence of reduced recruitment of brown and brite/beige adipocytes. Mechanistically, TRL processing by LAL induces proliferation of endothelial cells and adipocyte precursors via beta-oxidation-dependent production of reactive oxygen species, which in turn stimulates hypoxia-inducible factor-1α-dependent proliferative responses. In conclusion, this study demonstrates a physiological role for TRL particle uptake into BAT and WAT and establishes endothelial lipoprotein processing as an important determinant of adipose tissue remodeling during thermogenic adaptation.
650 7a NATURVETENSKAPx Biologix Cellbiologi0 (SwePub)106042 hsv//swe
650 7a NATURAL SCIENCESx Biological Sciencesx Cell Biology0 (SwePub)106042 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Cell- och molekylärbiologi0 (SwePub)301082 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Cell and Molecular Biology0 (SwePub)301082 hsv//eng
653 a angiogenesis
653 a beige adipocytes
653 a brown adipose tissue
653 a endothelial cells
653 a hypoxia-inducible factor 1α
653 a lipoproteins
653 a lysosomal acid lipase
653 a thermogenesis
653 a triglycerides
653 a white adipose tissue
7001 a Jaeckstein, Michelle Y.u Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany4 aut
7001 a Gottschling, Kristinau Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany4 aut
7001 a Heine, Markusu Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany4 aut
7001 a Sass, Frederikeu Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany4 aut
7001 a Mangels, Nilsu Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany4 aut
7001 a Schlein, Christianu Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany4 aut
7001 a Worthmann, Annau Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany4 aut
7001 a Bruns, Oliver T.u Helmholtz Pioneer Campus, Helmholtz Zentrum München, Neuherberg, Germany4 aut
7001 a Yuan, Yuchengu Department of Chemistry, Brown University, RI, Providence, United States4 aut
7001 a Zhu, Huau Department of Chemistry, Brown University, RI, Providence, United States4 aut
7001 a Chen, Ouu Department of Chemistry, Brown University, RI, Providence, United States4 aut
7001 a Ittrich, Haraldu Department of Diagnostic and Interventional Radiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany4 aut
7001 a Nilsson, Stefan K.,d 1979-u Umeå universitet,Fysiologisk kemi4 aut0 (Swepub:umu)nist6501
7001 a Stefanicka, Patriku Department of Otorhinolaryngology – Head and Neck Surgery, Comenius University, Bratislava, Slovakia4 aut
7001 a Ukropec, Jozefu Institute of Experimental Endocrinology, Biomedical Research Center at the Slovak Academy of Sciences, Bratislava, Slovakia4 aut
7001 a Balaz, Miroslavu Institute of Food, Nutrition and Health, ETH Zürich, Schwerzenbach, Switzerland4 aut
7001 a Dong, Huau Institute of Food, Nutrition and Health, ETH Zürich, Schwerzenbach, Switzerland4 aut
7001 a Sun, Wenfeiu Institute of Food, Nutrition and Health, ETH Zürich, Schwerzenbach, Switzerland4 aut
7001 a Reimer, Rudolfu Heinrich Pette Institute, Leibniz Institute for Experimental Virology, Hamburg, Germany4 aut
7001 a Scheja, Ludgeru Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany4 aut
7001 a Heeren, Joergu Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany4 aut
7102 a Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Department of Molecular Metabolism, Harvard T. H. Chan School of Public Health, MA, Boston, United States; Department of Cell Biology, Harvard Medical School, MA, Boston, United Statesb Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany4 org
7730 t Cell Metabolismd : Elsevierg 33:3, s. 547-564.e7q 33:3<547-564.e7x 1550-4131x 1932-7420
8564 u http://www.cell.com/article/S1550413120306562/pdf
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-186316
8564 8u https://doi.org/10.1016/j.cmet.2020.12.001

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