SwePub
Sök i LIBRIS databas

  Extended search

WFRF:(Marques Elisa)
 

Search: WFRF:(Marques Elisa) > Transcriptional Con...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00005729naa a2200781 4500
001oai:research.chalmers.se:2325d063-8d46-42cf-9b02-9967f7e36977
003SwePub
008180903s2018 | |||||||||||000 ||eng|
009oai:DiVA.org:su-160092
009oai:DiVA.org:uu-363938
009oai:prod.swepub.kib.ki.se:138953176
0247 a https://research.chalmers.se/publication/5047812 URI
0247 a https://doi.org/10.1016/j.devcel.2018.07.0052 DOI
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-1600922 URI
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3639382 URI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1389531762 URI
040 a (SwePub)cthd (SwePub)sud (SwePub)uud (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Marques, Sueliu Karolinska Institutet4 aut
2451 0a Transcriptional Convergence of Oligodendrocyte Lineage Progenitors during Development
264 1b Elsevier BV,c 2018
338 a electronic2 rdacarrier
520 a Pdgfra+ oligodendrocyte precursor cells (OPCs) arise in distinct specification waves during embryogenesis in the central nervous system (CNS). It is unclear whether there is a correlation between these waves and different oligodendrocyte (OL) states at adult stages. Here, we present bulk and single-cell transcriptomics resources providing insights on how transitions between these states occur. We found that post-natal OPCs from brain and spinal cord present similar transcriptional signatures. Moreover, post-natal OPC progeny of E13.5 Pdgfra+ cells present electrophysiological and transcriptional profiles similar to OPCs derived from subsequent specification waves, indicating that Pdgfra+ pre-OPCs rewire their transcriptional network during development. Single-cell RNA-seq and lineage tracing indicates that a subset of E13.5 Pdgfra+ cells originates cells of the pericyte lineage. Thus, our results indicate that embryonic Pdgfra+ cells in the CNS give rise to distinct post-natal cell lineages, including OPCs with convergent transcriptional profiles in different CNS regions.
650 7a NATURVETENSKAPx Biologix Cellbiologi0 (SwePub)106042 hsv//swe
650 7a NATURAL SCIENCESx Biological Sciencesx Cell Biology0 (SwePub)106042 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Cell- och molekylärbiologi0 (SwePub)301082 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Cell and Molecular Biology0 (SwePub)301082 hsv//eng
650 7a NATURVETENSKAPx Biologix Utvecklingsbiologi0 (SwePub)106142 hsv//swe
650 7a NATURAL SCIENCESx Biological Sciencesx Developmental Biology0 (SwePub)106142 hsv//eng
650 7a NATURVETENSKAPx Biologi0 (SwePub)1062 hsv//swe
650 7a NATURAL SCIENCESx Biological Sciences0 (SwePub)1062 hsv//eng
653 a transcription factors
653 a single-cell RNA-seq
653 a platelet-derived growth factor receptor alpha
653 a oligodendrocyte precursor cell
653 a myelin
653 a neural progenitors
653 a transcriptomics
653 a neural development
653 a pericyte
653 a oligodendrocyte
7001 a van Bruggen, Davidu Karolinska Institutet4 aut
7001 a Vanichkina, Darya Pavlovnau The University of Sydney,Univ Sydney, Centenary Inst, Gene & Stem Cell Therapy Program, Camperdown, NSW 2050, Australia;Univ Queensland, Inst Mol Biosci, St Lucia, Qld 4067, Australia4 aut
7001 a Floriddia, Elisa Mariagraziau Karolinska Institutet4 aut
7001 a Munguba, Hermanyu Karolinska Institutet4 aut
7001 a Wigge, Leif,d 1986u Chalmers tekniska högskola,Chalmers University of Technology4 aut0 (Swepub:cth)varemo
7001 a Giacomello, Stefaniau Stockholms universitet,Institutionen för biokemi och biofysik,Science for Life Laboratory (SciLifeLab),Stockholm Univ, Dept Biochem & Biophys, Sci Life Lab, Box 1031, S-17121 Solna, Sweden4 aut0 (Swepub:su)sgiac
7001 a Falcão, Ana Mendanhau Karolinska Institutet4 aut
7001 a Meijer, Mandyu Karolinska Institutet4 aut
7001 a Björklund, Åsa K.u Uppsala universitet,Molekylär evolution,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:uu)asbjo172
7001 a Hjerling-Leffler, Jensu Karolinska Institutet4 aut
7001 a Taft, Ryan Jamesu University of Queensland,Univ Queensland, Inst Mol Biosci, St Lucia, Qld 4067, Australia;Illumina Inc, San Diego, CA 92122 USA4 aut
7001 a Castelo-Branco, Gonçalou Karolinska Institutet4 aut
7001 a Väremo, Leifu Chalmers Univ Technol, Dept Biol & Biol Engn, Sci Life Lab, Kemivagen 10, S-41296 Gothenburg, Sweden4 aut
7102 a Karolinska Institutetb The University of Sydney4 org
7730 t Developmental Celld : Elsevier BVg 46:4, s. 504-517q 46:4<504-517x 1878-1551x 1534-5807
8564 u https://research.chalmers.se/publication/504781/file/504781_Fulltext.pdfx primaryx freey FULLTEXT
8564 u http://www.cell.com/article/S1534580718305586/pdf
8564 u https://doi.org/10.1016/j.devcel.2018.07.005y Fulltext
8564 u https://uu.diva-portal.org/smash/get/diva2:1258053/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
8564 8u https://research.chalmers.se/publication/504781
8564 8u https://doi.org/10.1016/j.devcel.2018.07.005
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-160092
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-363938
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:138953176

Find in a library

To the university's database

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Close

Copy and save the link in order to return to this view