WFRF:(Nieuwdorp Max)
Sökning: WFRF:(Nieuwdorp Max) > (2020-2023) > Protein Phosphatase...
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 03957naa a2200409 4500 | |
| 001 | oai:gup.ub.gu.se/310838 | |
| 003 | SwePub | |
| 008 | 240528s2021 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://gup.ub.gu.se/publication/3108382 URI |
| 024 | 7 | a https://doi.org/10.1002/hep4.16302 DOI |
| 040 | a (SwePub)gu | |
| 041 | a eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Männistö, Ville4 aut |
| 245 | 1 0 | a Protein Phosphatase 1 Regulatory Subunit 3B Genotype at rs4240624 Has a Major Effect on Gallbladder Bile Composition |
| 264 | c 2020-11-25 | |
| 264 | 1 | b Ovid Technologies (Wolters Kluwer Health),c 2021 |
| 520 | a The protein phosphatase 1 regulatory subunit 3B (PPP1R3B) gene is a target of farnesoid X receptor (FXR), which is a major regulator of bile acid metabolism. Both PPP1R3B and FXR have been suggested to take part in glycogen metabolism, which may explain the association of PPP1R3B gene variants with altered hepatic computed tomography attenuation. We analyzed the effect of PPP1R3B rs4240624 variant on bile acid composition in individuals with obesity. The study cohort consisted of 242 individuals from the Kuopio Obesity Surgery Study (73 men, 169 women, age 47.6±9.0years, body mass index 43.2±5.4kg/m2) with PPP1R3B genotype and liver RNA sequencing (RNA-seq) data available. Fasting plasma and gallbladder bile samples were collected from 50 individuals. Bile acids in plasma did not differ based on the PPP1R3B rs4240624 genotype. However, the concentration of total bile acids (109±55 vs. 35±19mM; P=1.0×10−5) and all individual bile acids (also 7α-hydroxy-4-cholesten-3-one [C4]) measured from bile were significantly lower in those with the AG genotype compared to those with the AA genotype. In addition, total cholesterol (P=0.011) and phospholipid (P=0.001) levels were lower in individuals with the AG genotype, but cholesterol saturation index did not differ, indicating that the decrease in cholesterol and phospholipid levels was secondary to the change in bile acids. Liver RNA-seq data demonstrated that expression of PPP1R3B, tankyrase (TNKS), Homo sapiens chromosome 8 clone RP11-10A14.5 (AC022784.1 [LOC157273]), Homo sapiens chromosome 8 clone RP11-375N15.1 (AC021242.1), and Homo sapiens chromosome 8, clone RP11-10A14 (AC022784.6) associated with the PPP1R3B genotype. In addition, genes enriched in transmembrane transport and phospholipid binding pathways were associated with the genotype. Conclusion: The rs4240624 variant in PPP1R3B has a major effect on the composition of gallbladder bile. Other transcripts in the same loci may be important mediators of the variant effect. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Gastroenterologi0 (SwePub)302132 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Gastroenterology and Hepatology0 (SwePub)302132 hsv//eng |
| 700 | 1 | a Kaminska, Dorota4 aut |
| 700 | 1 | a Käkelä, Pirjo4 aut |
| 700 | 1 | a Neuvonen, Mikko4 aut |
| 700 | 1 | a Niemi, Mikko4 aut |
| 700 | 1 | a Alvarez, Marcus4 aut |
| 700 | 1 | a Pajukanta, Päivi4 aut |
| 700 | 1 | a Romeo, Stefano,d 1976u Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine4 aut0 (Swepub:gu)xroste |
| 700 | 1 | a Nieuwdorp, Max4 aut |
| 700 | 1 | a Groen, Albert K.4 aut |
| 700 | 1 | a Pihlajamäki, Jussi4 aut |
| 710 | 2 | a Göteborgs universitetb Institutionen för medicin, avdelningen för molekylär och klinisk medicin4 org |
| 773 | 0 | t Hepatology Communicationsd : Ovid Technologies (Wolters Kluwer Health)g 5, s. 244-257q 5<244-257x 2471-254X |
| 856 | 4 | u https://aasldpubs.onlinelibrary.wiley.com/doi/pdfdirect/10.1002/hep4.1630 |
| 856 | 4 8 | u https://gup.ub.gu.se/publication/310838 |
| 856 | 4 8 | u https://doi.org/10.1002/hep4.1630 |
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