Once-weekly oral medication with alendronate does not prevent migration of knee prostheses: A double-blind randomized RSA study

Once-weekly oral medication with alendronate does not prevent migration of knee prostheses : A double-blind randomized RSA study

Aspenberg, Per (author): Östergötlands Läns Landsting,Linköpings universitet,Ortopedi och idrottsmedicin,Hälsouniversitetet,Ortopedkliniken Linköping

(creator_code:org_t)

2009-07-08
2009
English.
In: Acta Orthopaedica. - : Informa Healthcare. - 1745-3674 .- 1745-3682. ; 80:1, s. 41-45

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Abstract Subject headings

Background and purposeEarly migration of joint replacements is an effect of poor fixation and can predict late loosening. By reducing the bone resorption after implantation of a joint replacement, it should be possible to enhance the initial fixation of the implant. We studied the effect of once-weekly treatment with alendronate after knee replacement.Patients and methodsWe recruited 60 patients (60 knees) with gonarthrosis who were scheduled for a total knee replacement. They were operated on with identical implants and uncemented fixation. 30 patients were treated with a bisphosphonate (alendronate) and 30 patients underwent placebo treatment. The treatment started postoperatively and continued on a weekly basis for 6 months. The fixation of the implants was measured with repeated radiostereometry for 2 years.ResultsThere was no difference in migration of implants between the two groups.ConclusionWith uncemented fixation of knee implants, no benefit of once-weekly treatment with alendronate, starting postoperatively, could be seen during a 2-year follow-up period.

By the author/editor: Hansson, Ulrik; Toksvig-Larsen, ...; Ryd, Leif; Aspenberg, Per

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