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  • Rosengren, SaraUppsala universitet,Hematologi (author)

Diagnostic Accuracy of [11C]PIB Positron Emission Tomography for Detection of Cardiac Amyloidosis

  • Article/chapterEnglish2020

Publisher, publication year, extent ...

  • Elsevier BV,2020
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-418170
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-418170URI
  • https://doi.org/10.1016/j.jcmg.2020.02.023DOI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • OBJECTIVES: This dual-site study evaluated the diagnostic accuracy of the method.BACKGROUND: Pittsburgh compound ([11C]PIB) positron emission tomography (PIB-PET) has shown promise as a specific and noninvasive method for the diagnosis of cardiac amyloidosis (CA).METHODS: The study had 2 parts. In the initial study, 51 subjects were included, 36 patients with known CA and increased wall thickness (15 immunoglobulin light chain [AL] and 21 transthyretin [ATTR] amyloidosis) and 15 control patients (7 were nonamyloid hypertrophic and 8 healthy volunteers). Subjects underwent PIB-PET and echocardiography. Sensitivity and specificity of PIB-PET were established for 2 simple semiquantitative approaches, standardized uptake value ratio (SUVR) and retention index (RI). The second part of the study included 11 amyloidosis patients (5 AL and 6 hereditary ATTR) without increased wall thickness to which the optimal cutoff values of SUVR (>1.09) and RI (>0.037 min-1) were applied prospectively.RESULTS: The diagnostic accuracy of visual inspection of [11C]PIB uptake was 100% in discriminating CA patients with increased wall thickness from controls. Semiquantitative [11C]PIB uptake discriminated CA from controls with a 94% (95% confidence interval [CI]: 80% to 99%) sensitivity for both SUVR and RI and specificity of 93% (95% CI: 66% to 100%) for SUVR and 100% (95% CI: 75% to 100%) for RI. [11C]PIB uptake was significantly higher in AL-CA than in ATTR-CA patients (p < 0.001) and discriminated AL-CA from controls with 100% (95% CI: 88% to 100%) accuracy for both the semiquantitative measures. In the prospective group without increased wall thickness, RI was elevated compared to controls (p = 0.001) and 5 of 11 subjects were evaluated as [11C]PIB PET positive.CONCLUSIONS: In a dual-center setting, [11C]PIB PET was highly accurate in detecting cardiac involvement in the main amyloid subtypes, with 100% accuracy in AL amyloidosis. A proportion of amyloidosis patients without known cardiac involvement were [11C]PIB PET positive, indicating that the method may detect early stages of CA.

Subject headings and genre

  • PET
  • Pittsburgh compound B
  • diagnosis
  • heart
  • nuclear imaging

Added entries (persons, corporate bodies, meetings, titles ...)

  • Skibsted Clemmensen, Tor (author)
  • Tolbod, Lars (author)
  • Granstam, Sven-Olof,1963-Uppsala universitet,Klinisk fysiologi(Swepub:uu)svolgran (author)
  • Eiskjær, Hans (author)
  • Wikström, GerhardUppsala universitet,Kardiologi(Swepub:uu)gewik021 (author)
  • Vedin, OlaUppsala universitet,Kardiologi(Swepub:uu)olved933 (author)
  • Kero, TanjaUppsala universitet,Radiologi(Swepub:uu)tanke311 (author)
  • Lubberink, MarkUppsala universitet,Radiologi,Institutionen för immunologi, genetik och patologi(Swepub:uu)marklubb (author)
  • Harms, Hendrik J (author)
  • Flachskampf, Frank A,1957-Uppsala universitet,Klinisk fysiologi(Swepub:uu)frafl698 (author)
  • Baron, TomaszUppsala universitet,Klinisk fysiologi(Swepub:uu)tomba515 (author)
  • Carlson, KristinaUppsala universitet,Hematologi(Swepub:uu)krica965 (author)
  • Mikkelsen, Fabian (author)
  • Antoni, GunnarUppsala universitet,Preparativ läkemedelskemi(Swepub:uu)gunnarat (author)
  • Frost Andersen, Niels (author)
  • Hvitfeldt Poulsen, Steen (author)
  • Sörensen, JensUppsala universitet,Radiologi(Swepub:uu)jenssore (author)
  • Uppsala universitetHematologi (creator_code:org_t)

Related titles

  • In:JACC Cardiovascular Imaging: Elsevier BV13:6, s. 1337-13471936-878X1876-7591

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