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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00004620naa a2200529 4500
001oai:DiVA.org:uu-418170
003SwePub
008200831s2020 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4181702 URI
0247 a https://doi.org/10.1016/j.jcmg.2020.02.0232 DOI
040 a (SwePub)uu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Rosengren, Sarau Uppsala universitet,Hematologi4 aut0 (Swepub:uu)sarro118
2451 0a Diagnostic Accuracy of [11C]PIB Positron Emission Tomography for Detection of Cardiac Amyloidosis
264 1b Elsevier BV,c 2020
338 a print2 rdacarrier
520 a OBJECTIVES: This dual-site study evaluated the diagnostic accuracy of the method.BACKGROUND: Pittsburgh compound ([11C]PIB) positron emission tomography (PIB-PET) has shown promise as a specific and noninvasive method for the diagnosis of cardiac amyloidosis (CA).METHODS: The study had 2 parts. In the initial study, 51 subjects were included, 36 patients with known CA and increased wall thickness (15 immunoglobulin light chain [AL] and 21 transthyretin [ATTR] amyloidosis) and 15 control patients (7 were nonamyloid hypertrophic and 8 healthy volunteers). Subjects underwent PIB-PET and echocardiography. Sensitivity and specificity of PIB-PET were established for 2 simple semiquantitative approaches, standardized uptake value ratio (SUVR) and retention index (RI). The second part of the study included 11 amyloidosis patients (5 AL and 6 hereditary ATTR) without increased wall thickness to which the optimal cutoff values of SUVR (>1.09) and RI (>0.037 min-1) were applied prospectively.RESULTS: The diagnostic accuracy of visual inspection of [11C]PIB uptake was 100% in discriminating CA patients with increased wall thickness from controls. Semiquantitative [11C]PIB uptake discriminated CA from controls with a 94% (95% confidence interval [CI]: 80% to 99%) sensitivity for both SUVR and RI and specificity of 93% (95% CI: 66% to 100%) for SUVR and 100% (95% CI: 75% to 100%) for RI. [11C]PIB uptake was significantly higher in AL-CA than in ATTR-CA patients (p < 0.001) and discriminated AL-CA from controls with 100% (95% CI: 88% to 100%) accuracy for both the semiquantitative measures. In the prospective group without increased wall thickness, RI was elevated compared to controls (p = 0.001) and 5 of 11 subjects were evaluated as [11C]PIB PET positive.CONCLUSIONS: In a dual-center setting, [11C]PIB PET was highly accurate in detecting cardiac involvement in the main amyloid subtypes, with 100% accuracy in AL amyloidosis. A proportion of amyloidosis patients without known cardiac involvement were [11C]PIB PET positive, indicating that the method may detect early stages of CA.
653 a PET
653 a Pittsburgh compound B
653 a diagnosis
653 a heart
653 a nuclear imaging
7001 a Skibsted Clemmensen, Tor4 aut
7001 a Tolbod, Lars4 aut
7001 a Granstam, Sven-Olof,d 1963-u Uppsala universitet,Klinisk fysiologi4 aut0 (Swepub:uu)svolgran
7001 a Eiskjær, Hans4 aut
7001 a Wikström, Gerhardu Uppsala universitet,Kardiologi4 aut0 (Swepub:uu)gewik021
7001 a Vedin, Olau Uppsala universitet,Kardiologi4 aut0 (Swepub:uu)olved933
7001 a Kero, Tanjau Uppsala universitet,Radiologi4 aut0 (Swepub:uu)tanke311
7001 a Lubberink, Marku Uppsala universitet,Radiologi,Institutionen för immunologi, genetik och patologi4 aut0 (Swepub:uu)marklubb
7001 a Harms, Hendrik J4 aut
7001 a Flachskampf, Frank A,d 1957-u Uppsala universitet,Klinisk fysiologi4 aut0 (Swepub:uu)frafl698
7001 a Baron, Tomaszu Uppsala universitet,Klinisk fysiologi4 aut0 (Swepub:uu)tomba515
7001 a Carlson, Kristinau Uppsala universitet,Hematologi4 aut0 (Swepub:uu)krica965
7001 a Mikkelsen, Fabian4 aut
7001 a Antoni, Gunnaru Uppsala universitet,Preparativ läkemedelskemi4 aut0 (Swepub:uu)gunnarat
7001 a Frost Andersen, Niels4 aut
7001 a Hvitfeldt Poulsen, Steen4 aut
7001 a Sörensen, Jensu Uppsala universitet,Radiologi4 aut0 (Swepub:uu)jenssore
7102 a Uppsala universitetb Hematologi4 org
7730 t JACC Cardiovascular Imagingd : Elsevier BVg 13:6, s. 1337-1347q 13:6<1337-1347x 1936-878Xx 1876-7591
8564 u https://doi.org/10.1016/j.jcmg.2020.02.023
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-418170
8564 8u https://doi.org/10.1016/j.jcmg.2020.02.023

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