L773:0966 3274 OR L773:1878 5492
Sökning: L773:0966 3274 OR L773:1878 5492 > Increased IFN-? res...
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 02431naa a2200289 4500 | |
| 001 | oai:DiVA.org:liu-26418 | |
| 003 | SwePub | |
| 008 | 091008s2003 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-264182 URI |
| 024 | 7 | a https://doi.org/10.1016/S0966-3274(02)00146-62 DOI |
| 040 | a (SwePub)liu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Svenvik, Mu Östergötlands Läns Landsting,Linköpings universitet,Hälsouniversitetet,Klinisk immunologi,Klinisk immunologi och transfusionsmedicin4 aut |
| 245 | 1 0 | a Increased IFN-? response to transplantation antigens measured by cytokine MLC :b Indications for a bi-phasic response pattern |
| 264 | 1 | c 2003 |
| 338 | a print2 rdacarrier | |
| 520 | a The immunological reactivity to major histocompatibility transplantation antigens (MHC) is important in clinical manifestations such as graft rejection and graft-vs.-host disease. To evaluate the allogeneic cytokine response pattern we used a newly developed cytokine mixed leukocyte culture (MLC) technique. Blood mononuclear cells from healthy women (n=6) were exposed to cells from another person and to pooled cells from 28 blood donors (MHC-pool). The secretion kinetics of IL-4 and IFN-? from the responder cells was analysed by ELISPOT. We found a higher IFN-? response to the MHC-pool compared with the IL-4 secretion. Both the total secretion of IFN-? for 7 days and the median value of IFN-? in each individual was increased compared with IL-4. The IFN-? response showed a bi-phasic pattern with the major peak on day 6-7. Our results indicate that allo-responses are mainly Thl-like responses, displaying a bi-phasic pattern. This knowledge may be useful, and the methods suitable, in the studies of allo-responses in transplantation and pregnancy. | |
| 653 | a MEDICINE | |
| 653 | a MEDICIN | |
| 700 | 1 | a Ekerfelt, Christina,d 1957-u Östergötlands Läns Landsting,Linköpings universitet,Hälsouniversitetet,Klinisk immunologi,Klinisk immunologi och transfusionsmedicin4 aut0 (Swepub:liu)chrek55 |
| 710 | 2 | a Linköpings universitetb Hälsouniversitetet4 org |
| 773 | 0 | t Transplant Immunologyg 11:1, s. 101-105q 11:1<101-105x 0966-3274x 1878-5492 |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-26418 |
| 856 | 4 8 | u https://doi.org/10.1016/S0966-3274(02)00146-6 |
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