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Sökning: L773:1879 1220 OR L773:0960 0760 > (2005-2009) > Novel estrogen rece...
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 03022naa a2200421 4500 | |
| 001 | oai:DiVA.org:uu-14692 | |
| 003 | SwePub | |
| 008 | 080131s2007 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-146922 URI |
| 024 | 7 | a https://doi.org/10.1016/j.jsbmb.2006.09.0352 DOI |
| 040 | a (SwePub)uu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Figtree, G. A.4 aut |
| 245 | 1 0 | a Novel estrogen receptor alpha promoter polymorphism increases ventricular hypertrophic response to hypertension |
| 264 | 1 | b Elsevier BV,c 2007 |
| 338 | a print2 rdacarrier | |
| 520 | a Given the strong genetic contribution to blood pressure and left ventricular hypertrophy (LVH), and the influence of estrogen on these parameters, we hypothesized that polymorphisms in the estrogen receptor alpha (ERα) promoter may influence LVH. Three novel polymorphisms were identified upstream of the ERα alternatively spliced exon 1E, within sequence which demonstrated significant promoter activity in vitro. Demonstration of ERα E isoform expression in human ventricle by RT-PCR supported a possible functional role for the 1E novel polymorphisms in estrogen signaling in the heart. Indeed, G > A (-721 E) was significantly associated with LVH after controlling for systolic blood pressure and sex in a healthy population (n = 74), contributing to 23% of interventricular septum (IVS) width variance (p < 0.001) and 9.4% of left ventricular mass index (LVMI) variance (p = 0.035). In a separate hypertensive cohort, male carriers of the A allele (n = 8) had a 17% increase in IVS (95% CI: 6-28%) and a 19% increase in LVMI (3-34%) compared to GG homozygotes (n = 84). We conclude that a novel polymorphism in the promoter of a cardiac mRNA splice isoform of ERα is associated with LVH. | |
| 653 | a Aldosterone | |
| 653 | a Gender differences | |
| 653 | a Genetic association studies | |
| 653 | a Hypertrophy/remodelling | |
| 653 | a Sex hormones | |
| 653 | a MEDICINE | |
| 653 | a MEDICIN | |
| 700 | 1 | a Kindmark, Andreasu Uppsala universitet,Institutionen för medicinska vetenskaper,Metabolic Bone Diseases4 aut0 (Swepub:uu)andrkind |
| 700 | 1 | a Lind, Larsu Uppsala universitet,Institutionen för medicinska vetenskaper4 aut0 (Swepub:uu)larslind |
| 700 | 1 | a Grundberg, Elinu Uppsala universitet,Institutionen för medicinska vetenskaper,Metabolic Bone Diseases4 aut0 (Swepub:uu)elgru677 |
| 700 | 1 | a Speller, B.4 aut |
| 700 | 1 | a Robinson, B.G.4 aut |
| 700 | 1 | a Channon, K.M.4 aut |
| 700 | 1 | a Watkins, H.4 aut |
| 710 | 2 | a Uppsala universitetb Institutionen för medicinska vetenskaper4 org |
| 773 | 0 | t Journal of Steroid Biochemistry and Molecular Biologyd : Elsevier BVg 103:2, s. 110-118q 103:2<110-118x 0960-0760x 1879-1220 |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-14692 |
| 856 | 4 8 | u https://doi.org/10.1016/j.jsbmb.2006.09.035 |
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