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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00003327naa a2200397 4500
001oai:prod.swepub.kib.ki.se:140590340
003SwePub
008240701s2019 | |||||||||||000 ||eng|
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1405903402 URI
0247 a https://doi.org/10.1038/s41398-019-0432-72 DOI
040 a (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Aas, M4 aut
2451 0a Telomere length is associated with childhood trauma in patients with severe mental disorders
264 c 2019-03-21
264 1b Springer Science and Business Media LLC,c 2019
520 a Reduced telomere length (TL) and structural brain abnormalities have been reported in patients with schizophrenia (SZ) and bipolar disorder (BD). Childhood traumatic events are more frequent in SZ and BD than in healthy individuals (HC), and based on recent findings in healthy individuals could represent one important factor for TL and brain aberrations in patients. The study comprised 1024 individuals (SZ [n = 373]; BD [n = 249] and HC [n = 402]). TL was measured by quantitative polymerase chain reaction (qPCR), and childhood trauma was assessed using the Childhood Trauma Questionnaire (CTQ). Diagnosis was obtained by the Structured Clinical Interview (SCID) for the diagnostic and statistical manual of mental disorders-IV (DSM-IV). FreeSurfer was used to obtain regional and global brain volumes from T1-weighted magnetic resonance imaging (MRI) brain scans. All analyses were adjusted for current age and sex. Patients had on average shorter TL (F = 7.87, p = 0.005, Cohen’s d = 0.17) and reported more childhood trauma experiences than HC (χ2 = 148.9, p < 0.001). Patients with a history of childhood sexual, physical or emotional abuse had shorter TL relative to HC and to patients without a history of childhood abuse (F = 6.93, p = 0.006, Cohen’s d = 0.16). After adjusting for childhood abuse, no difference in TL was observed between patients and HC (p = 0.12). There was no statistically significant difference in reported childhood abuse exposure or TL between SZ and BD. Our analyses revealed no significant associations between TL and clinical characteristics or brain morphometry. We demonstrate shorter TL in SZ and BD compared with HC and showed that TL is sensitive to childhood trauma experiences. Further studies are needed to identify the biological mechanisms of this relationship.
7001 a Elvsashagen, T4 aut
7001 a Westlye, LT4 aut
7001 a Kaufmann, T4 aut
7001 a Athanasiu, L4 aut
7001 a Djurovic, S4 aut
7001 a Melle, I4 aut
7001 a van der Meer, D4 aut
7001 a Martin-Ruiz, C4 aut
7001 a Steen, NE4 aut
7001 a Agartz, Iu Karolinska Institutet4 aut
7001 a Andreassen, OA4 aut
7102 a Karolinska Institutet4 org
7730 t Translational psychiatryd : Springer Science and Business Media LLCg 9:1, s. 97-q 9:1<97-x 2158-3188
8564 u https://www.nature.com/articles/s41398-019-0432-7.pdf
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:140590340
8564 8u https://doi.org/10.1038/s41398-019-0432-7

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