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Sökning: WFRF:(Allin Kristine) > (2020) > Whole blood co-expr...

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FältnamnIndikatorerMetadata
00008320naa a2201189 4500
001oai:DiVA.org:umu-178117
003SwePub
008210105s2020 | |||||||||||000 ||eng|
009oai:DiVA.org:kth-287829
009oai:lup.lub.lu.se:a268e336-6dd4-4ad3-9f44-15cecb266a8b
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1781172 URI
0247 a https://doi.org/10.1186/s13073-020-00806-62 DOI
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-2878292 URI
0247 a https://lup.lub.lu.se/record/a268e336-6dd4-4ad3-9f44-15cecb266a8b2 URI
040 a (SwePub)umud (SwePub)kthd (SwePub)lu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Gudmundsdottir, Valborgu Technical University of Denmark4 aut
2451 0a Whole blood co-expression modules associate with metabolic traits and type 2 diabetes :b an IMI-DIRECT study
264 c 2020-12-01
264 1b BioMed Central,c 2020
338 a electronic2 rdacarrier
500 a QC 20210126
520 a Background: The rising prevalence of type 2 diabetes (T2D) poses a major global challenge. It remains unresolved to what extent transcriptomic signatures of metabolic dysregulation and T2D can be observed in easily accessible tissues such as blood. Additionally, large-scale human studies are required to further our understanding of the putative inflammatory component of insulin resistance and T2D. Here we used transcriptomics data from individuals with (n = 789) and without (n = 2127) T2D from the IMI-DIRECT cohorts to describe the co-expression structure of whole blood that mainly reflects processes and cell types of the immune system, and how it relates to metabolically relevant clinical traits and T2D.Methods: Clusters of co-expressed genes were identified in the non-diabetic IMI-DIRECT cohort and evaluated with regard to stability, as well as preservation and rewiring in the cohort of individuals with T2D. We performed functional and immune cell signature enrichment analyses, and a genome-wide association study to describe the genetic regulation of the modules. Phenotypic and trans-omics associations of the transcriptomic modules were investigated across both IMI-DIRECT cohorts.Results: We identified 55 whole blood co-expression modules, some of which clustered in larger super-modules. We identified a large number of associations between these transcriptomic modules and measures of insulin action and glucose tolerance. Some of the metabolically linked modules reflect neutrophil-lymphocyte ratio in blood while others are independent of white blood cell estimates, including a module of genes encoding neutrophil granule proteins with antibacterial properties for which the strongest associations with clinical traits and T2D status were observed. Through the integration of genetic and multi-omics data, we provide a holistic view of the regulation and molecular context of whole blood transcriptomic modules. We furthermore identified an overlap between genetic signals for T2D and co-expression modules involved in type II interferon signaling.Conclusions: Our results offer a large-scale map of whole blood transcriptomic modules in the context of metabolic disease and point to novel biological candidates for future studies related to T2D.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng
653 a Type 2 diabetes
653 a Transcriptomics
653 a Co-expression modules
653 a Omics data integration
653 a Co-expression modules
653 a Omics data integration
653 a Transcriptomics
653 a Type 2 diabetes
7001 a Pedersen, Helle Krogh4 aut
7001 a Mazzoni, Gianluca4 aut
7001 a Allin, Kristine H.4 aut
7001 a Artati, Anna4 aut
7001 a Beulens, Joline W.4 aut
7001 a Banasik, Karina4 aut
7001 a Brorsson, Caroline4 aut
7001 a Cederberg, Henna4 aut
7001 a Chabanova, Elizaveta4 aut
7001 a De Masi, Federico4 aut
7001 a Elders, Petra J.4 aut
7001 a Forgie, Ian4 aut
7001 a Giordano, Nicku Lund University,Lunds universitet,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups4 aut0 (Swepub:lu)med-geg
7001 a Grallert, Harald4 aut
7001 a Gupta, Ramneek4 aut
7001 a Haid, Mark4 aut
7001 a Hansen, Torben4 aut
7001 a Hansen, Tue H.4 aut
7001 a Hattersley, Andrew T.4 aut
7001 a Heggie, Alison4 aut
7001 a Hong, Mun-Gwanu KTH,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:kth)u19gmsru
7001 a Jones, Angus G.4 aut
7001 a Koivula, Robertu Lund University,Lunds universitet,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups4 aut0 (Swepub:lu)med-rkl
7001 a Kokkola, Tarja4 aut
7001 a Laakso, Markku4 aut
7001 a Longreen, Peter4 aut
7001 a Mahajan, Anubha4 aut
7001 a Mari, Andrea4 aut
7001 a McDonald, Timothy J.4 aut
7001 a McEvoy, Donna4 aut
7001 a Musholt, Petra B.4 aut
7001 a Pavo, Imre4 aut
7001 a Prehn, Cornelia4 aut
7001 a Ruetten, Hartmut4 aut
7001 a Ridderstråle, Martinu Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups4 aut0 (Swepub:lu)endo-mri
7001 a Rutters, Femke4 aut
7001 a Sharma, Sapna4 aut
7001 a Slieker, Roderick C.4 aut
7001 a Syed, Ali4 aut
7001 a Tajes, Juan Fernandez4 aut
7001 a Thomas, Cecilia Engelu KTH,Affinitets-proteomik,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:kth)u1ja1scu
7001 a Thomsen, Henrik S.4 aut
7001 a Vangipurapu, Jagadish4 aut
7001 a Vestergaard, Henrik4 aut
7001 a Vinuela, Ana4 aut
7001 a Wesolowska-Andersen, Agata4 aut
7001 a Walker, Mark4 aut
7001 a Adamski, Jerzy4 aut
7001 a Schwenk, Jochen M.u KTH,Science for Life Laboratory, SciLifeLab,Affinitets-proteomik4 aut0 (Swepub:kth)u1h7wtme
7001 a McCarthy, Mark, I4 aut
7001 a Pearson, Ewan4 aut
7001 a Dermitzakis, Emmanouil4 aut
7001 a Franks, Paul W.u Umeå University,Lund University,Lunds universitet,Umeå universitet,Avdelningen för medicin,Genetic and Molecular Epidemiology Unit, Lund University Diabetes Centre, Department of Clinical Sciences, Clinical Research Centre, Lund University, Skåne University Hospital, Malmö, Sweden; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital, Oxford, UK; Department of Nutrition, Harvard School of Public Health, Boston, MA, USA,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups4 aut0 (Swepub:lu)med-plf
7001 a Pedersen, Oluf4 aut
7001 a Brunak, Sorenu University of Copenhagen,Technical University of Denmark4 aut
7102 a Technical University of Denmarkb Genetisk och molekylär epidemiologi4 org
7102 a et al.
7730 t Genome Medicined : BioMed Centralg 12:1q 12:1x 1756-994X
8564 u https://doi.org/10.1186/s13073-020-00806-6y Fulltext
8564 u https://umu.diva-portal.org/smash/get/diva2:1514315/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
8564 u https://genomemedicine.biomedcentral.com/track/pdf/10.1186/s13073-020-00806-6
8564 u http://dx.doi.org/10.1186/s13073-020-00806-6x freey FULLTEXT
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-178117
8564 8u https://doi.org/10.1186/s13073-020-00806-6
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-287829
8564 8u https://lup.lub.lu.se/record/a268e336-6dd4-4ad3-9f44-15cecb266a8b

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