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Serum thymidine kinase 1 activity in breast cancer
- Nisman, Benjamin (författare)
- Allweis, Tanir (författare)
- Kaduri, Luna (författare)
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- Maly, Bella (författare)
- Hamburger, Tamar (författare)
- Peretz, Tamar (författare)
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- (creator_code:org_t)
- 2010
- 2010
- Engelska.
- Ingår i: Cancer Biomarkers. - 1574-0153. ; 7:2, s. 65-72
- Tidskriftsartikel (refereegranskat)
Abstract
Ämnesord
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- Aims: Thymidine kinase 1 (TK1) is an enzyme involved in DNA synthesis and an important proliferation marker. We explored the association of preoperative serum TK1 activity with clinicopathological parameters and prognosis in terms of recurrence-free survival (RFS) in breast cancer (BC) patients. Patients and methods: TK1 activity in serum of 120 healthy women and 161 BC patients was measured by quantitative ELISA. Results: Serum TK1 activity in BC patients was significantly higher than in healthy women (P < 0.0001). In BC patients elevated TK1 activity was significantly associated with advanced T stage (P = 0.015), higher grade (P = 0.013), presence of tumor necrosis (P = 0.006), vascular invasion (P = 0.002), and lack of estrogen receptor (ER) and progesterone receptor (PR) expression (P = 0.0004 and P = 0.003). Higher TK1 activity was found in patients with BRCA1/2 mutations compared to those without the mutation (P = 0.004). Multivariate Cox proportional hazards analyses demonstrated that TK1, adjusted for stage, grade, necrosis, ER and PR negativity was retained as an independent predictor of disease recurrence (Hazard Ratio = 3.9, 95%CI 1.3-11.6, P = 0.013). Conclusion: Elevated serum TK1 is an important risk factor indicating a high proliferation potential of tumors at the time of excision. In multivariate analysis TK1 activity was found to be an independent prognostic factor for RFS.
Nyckelord
- Breast cancer
- thymidine kinase 1 activity
- prediction of recurrence
- BRCA1/2 mutation
- MEDICINE
- MEDICIN
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- Nisman, Benjamin
- Allweis, Tanir
- Kaduri, Luna
- Maly, Bella
- Gronowitz, Simon
- Hamburger, Tamar
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