WFRF:(Alvarez Contino JE)
Sökning: WFRF:(Alvarez Contino JE) > (2020) > Pan-cancer analysis...
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 09513naa a2201633 4500 | |
| 001 | oai:prod.swepub.kib.ki.se:142904545 | |
| 003 | SwePub | |
| 008 | 240913s2020 | |||||||||||000 ||eng| | |
| 009 | oai:lup.lub.lu.se:2d5c311f-b39f-44a5-82d2-efba3c9160b6 | |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1429045452 URI |
| 024 | 7 | a https://doi.org/10.1038/s41588-019-0562-02 DOI |
| 024 | 7 | a https://lup.lub.lu.se/record/2d5c311f-b39f-44a5-82d2-efba3c9160b62 URI |
| 040 | a (SwePub)kid (SwePub)lu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Rodriguez-Martin, Bu University of Santiago de Compostela4 aut |
| 245 | 1 0 | a Pan-cancer analysis of whole genomes identifies driver rearrangements promoted by LINE-1 retrotransposition |
| 264 | c 2020-02-05 | |
| 264 | 1 | b Springer Science and Business Media LLC,c 2020 |
| 520 | a About half of all cancers have somatic integrations of retrotransposons. Here, to characterize their role in oncogenesis, we analyzed the patterns and mechanisms of somatic retrotransposition in 2,954 cancer genomes from 38 histological cancer subtypes within the framework of the Pan-Cancer Analysis of Whole Genomes (PCAWG) project. We identified 19,166 somatically acquired retrotransposition events, which affected 35% of samples and spanned a range of event types. Long interspersed nuclear element (LINE-1; L1 hereafter) insertions emerged as the first most frequent type of somatic structural variation in esophageal adenocarcinoma, and the second most frequent in head-and-neck and colorectal cancers. Aberrant L1 integrations can delete megabase-scale regions of a chromosome, which sometimes leads to the removal of tumor-suppressor genes, and can induce complex translocations and large-scale duplications. Somatic retrotranspositions can also initiate breakage–fusion–bridge cycles, leading to high-level amplification of oncogenes. These observations illuminate a relevant role of 22 L1 retrotransposition in remodeling the cancer genome, with potential implications for the development of human tumors. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Medicinsk genetik0 (SwePub)301072 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Medical Genetics0 (SwePub)301072 hsv//eng |
| 653 | a Carcinogenesis/genetics | |
| 653 | a Gene Rearrangement/genetics | |
| 653 | a Genome, Human/genetics | |
| 653 | a Humans | |
| 653 | a Long Interspersed Nucleotide Elements/genetics | |
| 653 | a Neoplasms/genetics | |
| 653 | a Retroelements/genetics | |
| 700 | 1 | a Alvarez, EGu University of Santiago de Compostela4 aut |
| 700 | 1 | a Baez-Ortega, Au University of Cambridge4 aut |
| 700 | 1 | a Zamora, Ju University of Santiago de Compostela4 aut |
| 700 | 1 | a Supek, Fu Institute for Research in Biomedicine (IRB Barcelona)4 aut |
| 700 | 1 | a Demeulemeester, Ju Francis Crick Institute4 aut |
| 700 | 1 | a Santamarina, Mu University of Santiago de Compostela4 aut |
| 700 | 1 | a Ju, YSu Korea Advanced Institute of Science and Technology (KAIST)4 aut |
| 700 | 1 | a Temes, Ju University of Santiago de Compostela4 aut |
| 700 | 1 | a Garcia-Souto, Du University of Santiago de Compostela4 aut |
| 700 | 1 | a Detering, Hu University of Vigo4 aut |
| 700 | 1 | a Li, YLu Wellcome Trust Sanger Institute4 aut |
| 700 | 1 | a Rodriguez-Castro, Ju University of Santiago de Compostela4 aut |
| 700 | 1 | a Dueso-Barroso, Au University of Vic4 aut |
| 700 | 1 | a Bruzos, ALu University of Santiago de Compostela4 aut |
| 700 | 1 | a Dentro, SCu Francis Crick Institute4 aut |
| 700 | 1 | a Blanco, MGu University of Santiago de Compostela,Yale University4 aut |
| 700 | 1 | a Contino, Gu University of Cambridge4 aut |
| 700 | 1 | a Ardeljan, Du Johns Hopkins University4 aut |
| 700 | 1 | a Tojo, Mu University of Vigo4 aut |
| 700 | 1 | a Roberts, NDu Wellcome Trust Sanger Institute4 aut |
| 700 | 1 | a Zumalave, Su University of Santiago de Compostela4 aut |
| 700 | 1 | a Edwards, PAWu University of Cambridge4 aut |
| 700 | 1 | a Weischenfeldt, Ju European Molecular Biology Laboratory Heidelberg4 aut |
| 700 | 1 | a Puiggros, Mu Centro Nacional de Supercomputación4 aut |
| 700 | 1 | a Chong, ZCu University of Texas4 aut |
| 700 | 1 | a Chen, Ku University of Texas MD Anderson Cancer Center4 aut |
| 700 | 1 | a Lee, EAu Harvard Medical School4 aut |
| 700 | 1 | a Wala, JAu Broad Institute4 aut |
| 700 | 1 | a Raine, Ku Wellcome Trust Sanger Institute4 aut |
| 700 | 1 | a Butler, Au Wellcome Trust Sanger Institute4 aut |
| 700 | 1 | a Waszak, SMu European Molecular Biology Laboratory Heidelberg4 aut |
| 700 | 1 | a Navarro, FCPu Yale University4 aut |
| 700 | 1 | a Schumacher, SEu Broad Institute4 aut |
| 700 | 1 | a Monlong, Ju McGill University,University of Santiago de Compostela4 aut |
| 700 | 1 | a Maura, Fu Wellcome Trust Sanger Institute4 aut |
| 700 | 1 | a Bolli, Nu University of Milan4 aut |
| 700 | 1 | a Bourque, Gu McGill University4 aut |
| 700 | 1 | a Gerstein, M4 aut |
| 700 | 1 | a Park, PJu Harvard Medical School4 aut |
| 700 | 1 | a Wedge, DCu Wellcome Trust Sanger Institute4 aut |
| 700 | 1 | a Beroukhim, Ru Broad Institute4 aut |
| 700 | 1 | a Torrents, Du Catalan Institution for Research and Advanced Studies4 aut |
| 700 | 1 | a Korbel, JOu European Molecular Biology Laboratory Heidelberg4 aut |
| 700 | 1 | a Martincorena, Iu Wellcome Trust Sanger Institute4 aut |
| 700 | 1 | a Fitzgerald, RCu University of Cambridge4 aut |
| 700 | 1 | a Van Loo, Pu Francis Crick Institute4 aut |
| 700 | 1 | a Kazazian, HHu Johns Hopkins University4 aut |
| 700 | 1 | a Burns, KHu Johns Hopkins University4 aut |
| 700 | 1 | a Campbell, PJu Wellcome Trust Sanger Institute4 aut |
| 700 | 1 | a Tubio, JMC4 aut |
| 700 | 1 | a Akdemir, KC4 aut |
| 700 | 1 | a Boutros, PC4 aut |
| 700 | 1 | a Bowtell, DDL4 aut |
| 700 | 1 | a Brors, B4 aut |
| 700 | 1 | a Chan, K4 aut |
| 700 | 1 | a Cortes-Ciriano, I4 aut |
| 700 | 1 | a Dunford, AJ4 aut |
| 700 | 1 | a Edwards, PA4 aut |
| 700 | 1 | a Estivill, X4 aut |
| 700 | 1 | a Etemadmoghadam, D4 aut |
| 700 | 1 | a Feuerbach, L4 aut |
| 700 | 1 | a Fink, JL4 aut |
| 700 | 1 | a Frenkel-Morgenstern, M4 aut |
| 700 | 1 | a Garsed, DW4 aut |
| 700 | 1 | a Gordenin, DA4 aut |
| 700 | 1 | a Haan, D4 aut |
| 700 | 1 | a Haber, JE4 aut |
| 700 | 1 | a Hess, JM4 aut |
| 700 | 1 | a Hutter, B4 aut |
| 700 | 1 | a Imielinski, M4 aut |
| 700 | 1 | a Jones, DTW4 aut |
| 700 | 1 | a Kazanov, MD4 aut |
| 700 | 1 | a Klimczak, LJ4 aut |
| 700 | 1 | a Koh, Y4 aut |
| 700 | 1 | a Kumar, K4 aut |
| 700 | 1 | a Lee, JJK4 aut |
| 700 | 1 | a Lynch, AG4 aut |
| 700 | 1 | a Macintyre, G4 aut |
| 700 | 1 | a Markowetz, F4 aut |
| 700 | 1 | a Martinez-Fundichely, A4 aut |
| 700 | 1 | a Meyerson, M4 aut |
| 700 | 1 | a Miyano, S4 aut |
| 700 | 1 | a Nakagawa, H4 aut |
| 700 | 1 | a Ossowski, S4 aut |
| 700 | 1 | a Pearson, JV4 aut |
| 700 | 1 | a Rippe, K4 aut |
| 700 | 1 | a Roberts, SA4 aut |
| 700 | 1 | a Scully, R4 aut |
| 700 | 1 | a Shackleton, M4 aut |
| 700 | 1 | a Sidiropoulos, N4 aut |
| 700 | 1 | a Sieverling, L4 aut |
| 700 | 1 | a Stewart, C4 aut |
| 700 | 1 | a Villasante, I4 aut |
| 700 | 1 | a Waddell, N4 aut |
| 700 | 1 | a Yang, LX4 aut |
| 700 | 1 | a Yao, XT4 aut |
| 700 | 1 | a Yoon, SS4 aut |
| 700 | 1 | a Zhang, CZ4 aut |
| 700 | 1 | a Borg, Åkeu Lund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Familjär bröstcancer,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Familial Breast Cancer,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments4 cre0 (Swepub:lu)onk-abo |
| 700 | 1 | a Ringnér, Markusu Lund University,Lunds universitet,Molekylär cellbiologi,Biologiska institutionen,Naturvetenskapliga fakulteten,Molecular Cell Biology,Department of Biology,Faculty of Science4 cre0 (Swepub:lu)thep-mri |
| 700 | 1 | a Staaf, Johanu Lund University,Lunds universitet,Avdelningen för translationell cancerforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Forskningsgrupp Lungcancer,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Bröst/lungcancer,Sektion I,Institutionen för kliniska vetenskaper, Lund,Division of Translational Cancer Research,Department of Laboratory Medicine,Faculty of Medicine,Research Group Lung Cancer,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Breast/lungcancer,Section I,Department of Clinical Sciences, Lund4 cre0 (Swepub:lu)onk-jst |
| 710 | 2 | a University of Santiago de Compostelab University of Cambridge4 org |
| 773 | 0 | t Nature geneticsd : Springer Science and Business Media LLCg 52:3, s. 306-+q 52:3<306-+x 1546-1718x 1061-4036 |
| 856 | 4 | u https://www.nature.com/articles/s41588-019-0562-0.pdf |
| 856 | 4 | u http://dx.doi.org/10.1038/s41588-019-0562-0x freey FULLTEXT |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:142904545 |
| 856 | 4 8 | u https://doi.org/10.1038/s41588-019-0562-0 |
| 856 | 4 8 | u https://lup.lub.lu.se/record/2d5c311f-b39f-44a5-82d2-efba3c9160b6 |
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- Alvarez, EG
- Baez-Ortega, A
- Zamora, J
- Supek, F
- Demeulemeester, ...
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- Santamarina, M
- Ju, YS
- Temes, J
- Garcia-Souto, D
- Detering, H
- Li, YL
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- Dueso-Barroso, A
- Bruzos, AL
- Dentro, SC
- Blanco, MG
- Contino, G
- Ardeljan, D
- Tojo, M
- Roberts, ND
- Zumalave, S
- Edwards, PAW
- Weischenfeldt, J
- Puiggros, M
- Chong, ZC
- Chen, K
- Lee, EA
- Wala, JA
- Raine, K
- Butler, A
- Waszak, SM
- Navarro, FCP
- Schumacher, SE
- Monlong, J
- Maura, F
- Bolli, N
- Bourque, G
- Gerstein, M
- Park, PJ
- Wedge, DC
- Beroukhim, R
- Torrents, D
- Korbel, JO
- Martincorena, I
- Fitzgerald, RC
- Van Loo, P
- Kazazian, HH
- Burns, KH
- Campbell, PJ
- Tubio, JMC
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- Boutros, PC
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- Dunford, AJ
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- Gordenin, DA
- Haan, D
- Haber, JE
- Hess, JM
- Hutter, B
- Imielinski, M
- Jones, DTW
- Kazanov, MD
- Klimczak, LJ
- Koh, Y
- Kumar, K
- Lee, JJK
- Lynch, AG
- Macintyre, G
- Markowetz, F
- Martinez-Fundich ...
- Meyerson, M
- Miyano, S
- Nakagawa, H
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- Pearson, JV
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- Roberts, SA
- Scully, R
- Shackleton, M
- Sidiropoulos, N
- Sieverling, L
- Stewart, C
- Villasante, I
- Waddell, N
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- Yao, XT
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