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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00007314naa a2200745 4500
001oai:DiVA.org:uu-394646
003SwePub
008191017s2019 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3946462 URI
0247 a https://doi.org/10.3390/cancers110811032 DOI
040 a (SwePub)uu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Arce, Maximilianou Pontificia Univ Catolica Chile, Fac Biol Sci, Santiago 8331150, Chile;Adv Ctr Chron Dis ACCDiS, Santiago, Chile4 aut
2451 0a Coagulation Factor Xa Promotes Solid Tumor Growth, Experimental Metastasis and Endothelial Cell Activation
264 c 2019-08-02
264 1b MDPI,c 2019
338 a electronic2 rdacarrier
520 a Hypercoagulable state is linked to cancer progression; however, the precise role of the coagulation cascade is poorly described. Herein, we examined the contribution of a hypercoagulative state through the administration of intravenous Coagulation Factor Xa (FXa), on the growth of solid human tumors and the experimental metastasis of the B16F10 melanoma in mouse models. FXa increased solid tumor volume and lung, liver, kidney and lymph node metastasis of tail-vein injected B16F10 cells. Concentrating on the metastasis model, upon coadministration of the anticoagulant Dalteparin, lung metastasis was significantly reduced, and no metastasis was observed in other organs. FXa did not directly alter proliferation, migration or invasion of cancer cells in vitro. Alternatively, FXa upon endothelial cells promoted cytoskeleton contraction, disrupted membrane VE-Cadherin pattern, heightened endothelial-hyperpermeability, increased inflammatory adhesion molecules and enhanced B16F10 adhesion under flow conditions. Microarray analysis of endothelial cells treated with FXa demonstrated elevated expression of inflammatory transcripts. Accordingly, FXa treatment increased immune cell infiltration in mouse lungs, an effect reduced by dalteparin. Taken together, our results suggest that FXa increases B16F10 metastasis via endothelial cell activation and enhanced cancer cell-endothelium adhesion advocating that the coagulation system is not merely a bystander in the process of cancer metastasis.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
653 a cancer
653 a metastasis
653 a melanoma
653 a blood coagulation
653 a vascular endothelium
653 a inflammation
7001 a Pinto, Mauricio P.u Pontificia Univ Catolica Chile, Fac Med, Santiago 8331150, Chile4 aut
7001 a Galleguillos, Macarenau Pontificia Univ Catolica Chile, Fac Biol Sci, Santiago 8331150, Chile4 aut
7001 a Munoz, Catalinau Pontificia Univ Catolica Chile, Fac Biol Sci, Santiago 8331150, Chile4 aut
7001 a Lange, Soledadu Pontificia Univ Catolica Chile, Fac Biol Sci, Santiago 8331150, Chile4 aut
7001 a Ramirez, Carolinau Pontificia Univ Catolica Chile, Fac Biol Sci, Santiago 8331150, Chile4 aut
7001 a Erices, Rafaelau Pontificia Univ Catolica Chile, Fac Biol Sci, Santiago 8331150, Chile;Univ Mayor, Vicerrectoria Invest, Santiago 7510041, Chile4 aut
7001 a Gonzalez, Pamelau Pontificia Univ Catolica Chile, Fac Biol Sci, Santiago 8331150, Chile4 aut
7001 a Velasquez, Ethelu Pontificia Univ Catolica Chile, Fac Biol Sci, Santiago 8331150, Chile;Comis Chilena Energia Nucl CCHEN, Santiago, Chile4 aut
7001 a Tempio, Fabianu Univ Chile, Fac Med, Inst Biomed Sci, Santiago 8380453, Chile4 aut
7001 a Lopez, Mercedes N.u Univ Chile, Fac Med, Inst Biomed Sci, Santiago 8380453, Chile;Millennium Inst Immunol & Immunotherapy, Santiago 8331150, Chile4 aut
7001 a Salazar-Onfray, Flaviou Univ Chile, Fac Med, Inst Biomed Sci, Santiago 8380453, Chile;Millennium Inst Immunol & Immunotherapy, Santiago 8331150, Chile4 aut
7001 a Cautivo, Kellyu Pontificia Univ Catolica Chile, Fac Biol Sci, Santiago 8331150, Chile4 aut
7001 a Kalergis, Alexis M.u Pontificia Univ Catolica Chile, Fac Biol Sci, Santiago 8331150, Chile;Millennium Inst Immunol & Immunotherapy, Santiago 8331150, Chile;Biomed Res Consortium Chile, Santiago 8331010, Chile4 aut
7001 a Cruz, Sebastianu Fdn Ciencia & Vida, Lab Immunoncol, Santiago, Chile4 aut
7001 a Lladser, Alvarou Millennium Inst Immunol & Immunotherapy, Santiago 8331150, Chile;Fdn Ciencia & Vida, Lab Immunoncol, Santiago, Chile4 aut
7001 a Lobos-Gonzalez, Lorenau Adv Ctr Chron Dis ACCDiS, Santiago, Chile;Fdn Ciencia & Vida, Lab Immunoncol, Santiago, Chile;Univ Desarrollo, Fac Med, Regenerat Med Ctr, Clin Alemana, Santiago 7650568, Chile4 aut
7001 a Valenzuela, Guillermou Pontificia Univ Catolica Chile, Fac Med, Santiago 8331150, Chile4 aut
7001 a Olivares, Nixau Pontificia Univ Catolica Chile, Fac Med, Santiago 8331150, Chile4 aut
7001 a Saez, Claudiau Pontificia Univ Catolica Chile, Fac Med, Santiago 8331150, Chile4 aut
7001 a Koning, Taniau Univ Austral Chile, Fac Med, Immunol Inst, Valdivia 5110566, Chile4 aut
7001 a Sanchez, Fabiola A.u Univ Austral Chile, Fac Med, Immunol Inst, Valdivia 5110566, Chile4 aut
7001 a Fuenzalida, Patriciau Pontificia Univ Catolica Chile, Fac Biol Sci, Santiago 8331150, Chile4 aut
7001 a Godoy, Alejandrou Pontificia Univ Catolica Chile, Fac Biol Sci, Santiago 8331150, Chile;Roswell Pk Comprehens Canc Ctr, Dept Urol, Buffalo, NY 14203 USA4 aut
7001 a Contreras Orellana, Pamelau Adv Ctr Chron Dis ACCDiS, Santiago, Chile;Univ Chile, Fac Med, Lab Cellular Commun, ICBM, Santiago 8380453, Chile4 aut
7001 a Leyton, Lisetteu Adv Ctr Chron Dis ACCDiS, Santiago, Chile;Univ Chile, Fac Med, Lab Cellular Commun, ICBM, Santiago 8380453, Chile4 aut
7001 a Lugano, Robertau Uppsala universitet,Vaskulärbiologi4 aut0 (Swepub:uu)roblu911
7001 a Dimberg, Annau Uppsala universitet,Vaskulärbiologi4 aut0 (Swepub:uu)annadimb
7001 a Quest, Andrew F. G.u Adv Ctr Chron Dis ACCDiS, Santiago, Chile;Univ Chile, Fac Med, Lab Cellular Commun, ICBM, Santiago 8380453, Chile4 aut
7001 a Owen, Gareth, Iu Pontificia Univ Catolica Chile, Fac Biol Sci, Santiago 8331150, Chile;Adv Ctr Chron Dis ACCDiS, Santiago, Chile;Pontificia Univ Catolica Chile, Fac Med, Santiago 8331150, Chile;Millennium Inst Immunol & Immunotherapy, Santiago 8331150, Chile4 aut
7102 a Pontificia Univ Catolica Chile, Fac Biol Sci, Santiago 8331150, Chile;Adv Ctr Chron Dis ACCDiS, Santiago, Chileb Pontificia Univ Catolica Chile, Fac Med, Santiago 8331150, Chile4 org
7730 t Cancersd : MDPIg 11:8q 11:8x 2072-6694
8564 u https://doi.org/10.3390/cancers11081103y Fulltext
8564 u https://uu.diva-portal.org/smash/get/diva2:1362010/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
8564 u https://www.mdpi.com/2072-6694/11/8/1103/pdf
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-394646
8564 8u https://doi.org/10.3390/cancers11081103

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