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Complications after...
Complications after proton radiotherapy in children, focusing on severe late complications. A complete Swedish cohort 2008-2019
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- Martinsson, Ulla (författare)
- Uppsala University,Uppsala universitet,Cancerimmunterapi,Uppsala Univ, Sweden; Uppsala Univ Hosp, Sweden
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- Svärd, Anna-Maja (författare)
- Umeå University,Umeå universitet,Onkologi,Umeå Univ, Dept Radiat Sci, Oncol, Umeå, Sweden.
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- Witt Nyström, Petra (författare)
- Uppsala University,Uppsala universitet,Institutionen för immunologi, genetik och patologi,Uppsala Univ, Sweden
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- Embring, Anna (författare)
- Karolinska Institutet
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- Asklid, Anna (författare)
- Karolinska Institutet
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- Agrup, Måns, 1961- (författare)
- Linköping University,Linköpings universitet,Avdelningen för kirurgi, ortopedi och onkologi,Medicinska fakulteten,Region Östergötland, Onkologiska kliniken US
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- Haugen, Hedda (författare)
- Department of Oncology, Sahlgrenska University Hospital, Gothenburg, Sweden,Sahlgrens Univ Hosp, Dept Oncol, Gothenburg, Sweden.
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- Frojd, Charlotta (författare)
- Department of Oncology, Sahlgrenska University Hospital, Gothenburg, Sweden,Sahlgrens Univ Hosp, Dept Oncol, Gothenburg, Sweden.
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- Engellau, Jacob (författare)
- Lund University,Lunds universitet,Department of Oncology, Clinical Sciences, Lund University, Lund, Sweden,Lund Univ, Dept Oncol, Clin Sci, Lund, Sweden.,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Systemisk strålterapi,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Systemic radiation therapy,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine
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- Nilsson, Martin P. (författare)
- Lund University,Lunds universitet,Department of Oncology, Clinical Sciences, Lund University, Lund, Sweden,Lund Univ, Dept Oncol, Clin Sci, Lund, Sweden.,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Systemisk strålterapi,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Systemic radiation therapy,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine
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- Isacsson, Ulf (författare)
- Uppsala University,Uppsala universitet,Cancerprecisionsmedicin,Uppsala Univ, Sweden
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- Kristensen, Ingrid (författare)
- Department of Oncology, Clinical Sciences, Lund University, Lund, Sweden,Lund Univ, Dept Oncol, Clin Sci, Lund, Sweden.
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- Blomstrand, Malin, 1974 (författare)
- University of Gothenburg,Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för onkologi,Institute of Clinical Sciences, Department of Oncology,Department of Oncology, Sahlgrenska University Hospital, Gothenburg, Sweden; Department of Oncology, Institute of Clinical Sciences, University of Gothenburg, Sweden,Sahlgrens Univ Hosp, Dept Oncol, Gothenburg, Sweden.;Univ Gothenburg, Dept Oncol, Inst Clin Sci, Gothenburg, Sweden.
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(creator_code:org_t)
- Taylor & Francis, 2023
- 2023
- Engelska.
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Ingår i: ACTA ONCOLOGICA. - : Taylor & Francis. - 0284-186X .- 1651-226X. ; 62:10, s. 1348-1356
- Relaterad länk:
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https://doi.org/10.1...
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https://umu.diva-por... (primary) (Raw object)
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https://uu.diva-port... (primary) (Raw object)
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https://liu.diva-por... (primary) (Raw object)
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http://dx.doi.org/10... (free)
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://urn.kb.se/re...
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https://urn.kb.se/re...
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https://lup.lub.lu.s...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Background: Proton radiotherapy (RT) is an attractive tool to deliver local therapy with minimal dose to uninvolved tissue, however, not suitable for all patients. The aim was to explore complications, especially severe late complications (grades 3-4), following proton RT delivered to a complete Swedish cohort of paediatric patients aged <18 years treated 2008-2019.Material and Methods: Data was downloaded from a national registry. Complications with a possible causation with RT are reported. Proton treatments until July 2015 was performed with a fixed horizontal 172 MeV beam (The Svedberg Laboratory (TSL), Uppsala) in a sitting position and thereafter with gantry-based pencil-beam scanning technique (Skandion Clinic, Uppsala) in a supine position.Results: 219 courses of proton RT (77 at TSL and 142 at Skandion) were delivered to 212 patients (mean age 9.2 years) with various tumour types (CNS tumours 58%, sarcomas 26%, germ cell tumours 7%). Twenty-five patients had severe acute complications (skin, mucous membrane, pharynx/oesophagus, larynx, upper gastrointestinal canal, lower gastrointestinal canal, eyes, ears). Fifteen patients had severe late complications; with increased proportion over time: 4% at 1-year follow-up (FU), 5% at 3-year, 11% at 5-year. Organs affected were skin (1 patient), subcutaneous tissue (4), salivary glands (1), upper GI (1), bone (7), joints (2), CNS (2), PNS (1), eyes (1) and ears (5). Twenty-one of the 28 patients with 10-year FU had at least one late complication grades 1-4 and fourteen of them had more than one (2-5 each).Conclusion: The most important result of our study is the relatively low proportion of severe late complications, comparable with other proton studies on various tumours. Furthermore, the numbers of late complications are lower than our own data set on a mixed population of photon and proton treated paediatric patients, assuring the safety of using proton therapy also in the clinical practice.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kirurgi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Surgery (hsv//eng)
Nyckelord
- Proton radiotherapy
- children
- adolescents
- complications
- late effects
- adolescents
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Martinsson, Ulla
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Svärd, Anna-Maja
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Witt Nyström, Pe ...
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Embring, Anna
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Asklid, Anna
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Agrup, Måns, 196 ...
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Haugen, Hedda
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Frojd, Charlotta
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Engellau, Jacob
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Nilsson, Martin ...
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Isacsson, Ulf
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Kristensen, Ingr ...
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Blomstrand, Mali ...
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Cancer och onkol ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Kirurgi
- Artiklar i publikationen
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ACTA ONCOLOGICA
- Av lärosätet
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Göteborgs universitet
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Umeå universitet
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Uppsala universitet
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Linköpings universitet
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Lunds universitet
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Karolinska Institutet