WFRF:(Au Gough G.)
Sökning: WFRF:(Au Gough G.) > (2005-2009) > Oncolysis of vascul...
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 03452naa a2200505 4500 | |
| 001 | oai:DiVA.org:hik-936 | |
| 003 | SwePub | |
| 008 | 081211s2005 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:hik:diva-9362 URI |
| 040 | a (SwePub)lnu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Au, Gough Gu The University of Newcastle4 aut |
| 245 | 1 0 | a Oncolysis of vascular malignant human melanoma tumors by Coxsackievirus A21. |
| 264 | 1 | c 2005 |
| 338 | a print2 rdacarrier | |
| 520 | a Cultured melanoma cell lines despite exhibiting similar in vitro morphology, display significant phenotypic and growth rate differences when propagated as in vivo xenografts. Previously we have shown that Coxsackievirus A21 (CVA21) lytically infects in vitro cultures of malignant melanoma cells and is efficient at reducing the tumor burden of mice bearing slow-growing SK-Mel-28 melanoma xenografts. The oncolytic activity of CVA21 against in vivo melanoma xenografts, which possess rapid growth rates and more extensive vascular structure than SK-Mel-28 xenografts warrants further investigation. In the present study we evaluated the oncolytic action of CVA21 against rapidly growing melanoma xenografts (ME4405) which exhibit a highly vascular phenotype. Flow cytometric analysis indicated that in vitro cultures of ME4405 cells expressed comparable levels of the CVA21 cellular receptors, ICAM-1 (intercellular adhesion molecules-1) and DAF (decay accelerating factor) to SK-Mel-28 cells. Despite similar levels of CVA21 receptor expression, SK-Mel-28 cells appear to be more susceptible to viral lysis than ME4405 cells, even though the kinetics of virus replication in both lines was comparable. Intratumoral, intraperitoneal or intravenous administration of CVA21 were equally effective in reducing the tumor volume of ME4405 xenografts in immunodeficient mice, and provides further evidence for the use of CVA21 as a novel oncolytic agent against varying phenotypes of malignant melanoma. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Mikrobiologi inom det medicinska området0 (SwePub)301092 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Microbiology in the medical area0 (SwePub)301092 hsv//eng |
| 653 | a Coxsackievirus A21 | |
| 653 | a Oncolysis | |
| 653 | a Human melanoma | |
| 653 | a Xenograft mouse model | |
| 653 | a Intercellular-adhesion molecule-1 | |
| 653 | a Decay-accelerating factor | |
| 653 | a Complement-regulatory proteins | |
| 653 | a Differential expression | |
| 653 | a Mathematical-model | |
| 653 | a Cancer-treatment | |
| 653 | a Virus design | |
| 653 | a Icam-1 | |
| 653 | a Cells | |
| 653 | a Progression | |
| 653 | a Virology | |
| 653 | a Virologi | |
| 653 | a Virologi | |
| 653 | a Virology | |
| 700 | 1 | a Lindberg, A Michaelu Högskolan i Kalmar,Naturvetenskapliga institutionen4 aut0 (Swepub:lnu)nlimi |
| 700 | 1 | a Barry, Richard Du The University of Newcastle4 aut |
| 700 | 1 | a Shafren, Darren Ru The University of Newcastle4 aut |
| 710 | 2 | a The University of Newcastleb Naturvetenskapliga institutionen4 org |
| 773 | 0 | t International Journal of Oncologyg 26:6, s. 1471-6q 26:6<1471-6x 1019-6439x 1791-2423 |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:hik:diva-936 |
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