WFRF:(Benninga M. A.)
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 05125naa a2200721 4500 | |
| 001 | oai:gup.ub.gu.se/260775 | |
| 003 | SwePub | |
| 008 | 240528s2017 | |||||||||||000 ||eng| | |
| 009 | oai:openarchive.ki.se:10616/45966 | |
| 009 | oai:prod.swepub.kib.ki.se:135231261 | |
| 022 | a 0002-9270 | |
| 024 | 7 | a 10616/459662 hdl |
| 024 | 7 | a https://gup.ub.gu.se/publication/2607752 URI |
| 024 | 7 | a https://doi.org/10.1038/ajg.2016.5032 DOI |
| 024 | 7 | a http://hdl.handle.net/10616/459662 URI |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1352312612 URI |
| 040 | a (SwePub)gud (SwePub)kid (SwePub)ki | |
| 041 | a eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Bonnert, M.u Karolinska Institutet4 aut |
| 245 | 1 0 | a Internet-Delivered Cognitive Behavior Therapy for Adolescents With Irritable Bowel Syndrome: A Randomized Controlled Trial |
| 264 | 1 | a Stockholm :b Ovid Technologies (Wolters Kluwer Health),c 2017 |
| 520 | a OBJECTIVES: Few treatments have been able to effectively manage pediatric irritable bowel syndrome (IBS). Internet-delivered cognitive behavior therapy (Internet-CBT) based on exposure for abdominal symptoms is effective for adult IBS. The objective of this study was to evaluate the efficacy of Internet-CBT based on behavioral exposure for adolescents with IBS. METHODS: Adolescents with IBS fulfilling the Rome III criteria were randomized to either Internet-CBT or a wait-list control. The Internet-CBT was a 10-week intervention where the main component was exposure to IBS symptoms by reduction of avoidance of abdominal symptoms and instead stepwise provocation of symptoms. The primary outcome was total score on Gastrointestinal Symptoms Rating Scale for IBS (GSRS-IBS). Secondary outcomes included adolescent- and parent-rated quality of life and parent-rated gastrointestinal symptoms. Difference between groups was assessed from pretreatment to posttreatment and the Internet-CBT group was also evaluated at 6 months after treatment completion. RESULTS: A total of 101 adolescents with IBS (13-17 years of age) were included in this study. Dropout rates were low (6%) and all randomized patients were included in intent-to-treat analyses based on mixed effects models. Analyses showed a significant larger pretreatment to posttreatment change on the primary outcome GSRS-IBS (B=-6.42, P=0.006, effect size Cohen's d=0.45, 95% confidence interval (0.12, 0.77)) and on almost all secondary outcomes for the Internet-CBT group compared with the control group. After 6 months, the results were stable or significantly improved. CONCLUSIONS: Internet-CBT based on exposure exercises for adolescents with IBS can effectively improve gastrointestinal symptoms and quality of life. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicin0 (SwePub)3022 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicine0 (SwePub)3022 hsv//eng |
| 653 | a Adolescent | |
| 653 | a Cognitive Therapy/*methods | |
| 653 | a Constipation/etiology/physiopathology | |
| 653 | a Diarrhea/etiology/physiopathology | |
| 653 | a Female | |
| 653 | a Humans | |
| 653 | a *Internet | |
| 653 | a Irritable Bowel Syndrome/complications/physiopathology/*therapy | |
| 653 | a Male | |
| 653 | a Quality of Life | |
| 653 | a Severity of Illness Index | |
| 653 | a Therapy | |
| 653 | a Computer-Assisted/*methods | |
| 653 | a Treatment Outcome | |
| 700 | 1 | a Olen, O.u Karolinska Institutet4 aut |
| 700 | 1 | a Lalouni, M.u Karolinska Institutet4 aut |
| 700 | 1 | a Benninga, M. A.4 aut |
| 700 | 1 | a Bottai, M.u Karolinska Institutet4 aut |
| 700 | 1 | a Engelbrektsson, J.u Karolinska Institutet4 aut |
| 700 | 1 | a Hedman, E.u Karolinska Institutet4 aut |
| 700 | 1 | a Lenhard, F.u Karolinska Institutet4 aut |
| 700 | 1 | a Melin, B.4 aut |
| 700 | 1 | a Simrén, Magnus,d 1966u Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition4 aut0 (Swepub:gu)xsimrm |
| 700 | 1 | a Vigerland, S.u Karolinska Institutet4 aut |
| 700 | 1 | a Serlachius, E.u Karolinska Institutet4 aut |
| 700 | 1 | a Ljotsson, B.u Karolinska Institutet4 aut |
| 710 | 2 | a Karolinska Institutetb Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition4 org |
| 710 | 2 | a Karolinska Institutet |
| 710 | 2 | a Karolinska Institutet |
| 773 | 0 | t Am J Gastroenterold Stockholm : Ovid Technologies (Wolters Kluwer Health)g 112:1, s. 152-162q 112:1<152-162x 0002-9270x 1572-0241 |
| 856 | 4 | u http://openarchive.ki.se/xmlui/bitstream/10616/45966/5/10.1038_ajg.2016.503.pdf |
| 856 | 4 | u http://hdl.handle.net/10616/45966x primaryx Object in contextx freey FULLTEXT |
| 856 | 4 8 | u https://gup.ub.gu.se/publication/260775 |
| 856 | 4 8 | u https://doi.org/10.1038/ajg.2016.503 |
| 856 | 4 8 | u http://hdl.handle.net/10616/45966 |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:135231261 |
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